An analytical "quality by design" approach in RP-HPLC method development and validation for reliable and rapid estimation of irinotecan in an injectable formulation.

The objective of the present study was to develop a robust, simple, economical and sensitive HPLC-UV method using the "quality-by-design" approach for the estimation of irinotecan (IRI) in marketed formulations. RP-HPLC method was developed by applying Box-Behnken design with Hyper-Clone (Phenomenex®) C18 column (250 × 4.6 mm id, particle size 5 µm, ODS 130 Å) as a stationary phase.

Effect of Hip Prosthesis on Photon Beam Characteristics in Radiological Physics.

Introduction: Aim of study is to investigate the effect of hip prosthesis on 6 and 15 MV photon beam energies.

Materials And Methods: Prosthesis was kept at the level of tray position. The measurements were done on Varian Clinac-iX linac.

Isolated central nervous system relapse of multiple myeloma post autologous stem cell transplant- A rare presentation.

•CNS relapse in multiple myeloma after ASCT without medullary relapse is uncommon.•Isolated CNS relapse is extremely rare with only 7 cases reported in literature.•Prognosis is poor with very short median survival after detection of CNS relapse.

A Real-world Perspective of CD123 Expression in Acute Leukemia as Promising Biomarker to Predict Treatment Outcome in B-ALL and AML.

Introduction: CD123 is overexpressed in many hematologic malignancies and found to be useful in characterizing leukemic blasts of both acute myeloid leukemia (AML) and B-acute lymphoblastic leukemia (B-ALL). CD123 has been recently found to be a marker of leukemic stem cells, and its utility to measure residual disease and potential role in disease relapse is under evaluation.

Materials And Methods: Herein, we have evaluated the expression of CD123 in 757 samples of acute leukemia including 479 treatment-naive and 278 follow-up samples and compared with post-induction morphologic complete remission and measurable residual disease (MRD) status.

Impact of acuros XB algorithm in deep-inspiration breath-hold (DIBH) respiratory techniques used for the treatment of left breast cancer.

Aim: To investigate the impact of Acuros XB (AXB) algorithm in the deep-inspiration breath-hold (DIBH) technique used for treatment of left sided breast cancer.

Background: AXB may estimate better lung toxicities and treatment outcome in DIBH.

Materials And Methods: Treatment plans were computed using the field-in-field technique for a 6 MV beam in two respiratory phases - free breathing (FB) and DIBH.

Transcending the Cutaneous Barrier Through Nanocarrier Exploration for Passive Delivery of Anti-hypertensive Drugs: A Critical Review.

Background: Hypertension comes under the category of chronic disease, which requires long term treatment. Hypertension is usually treated by oral administration of various therapeutic agents. There are several limitations of the oral route, making pharmaceutical scientists to discover an alternative route for drug delivery.

Clinicopathological Profile of Castleman's Disease in Indian Population: Experience From a Tertiary Care Center.

Castleman's disease (CD), also known as angiofollicular lymph node hyperplasia, a rare, non-malignant chronic lymphoproliferative disease characterized by, uni or multicentric lymphadenopathy. There is limited information about the clinicopathological variations and associations of this entity. A total of 50 cases of CD were retrieved from the archives, between the years 2005-2017.

Land use change affects water erosion in the Nepal Himalayas.

Soil erosion is a global environmental threat, and Land Use Land Cover Changes (LUCC) have significant impacts on it. Nepal, being a mountainous country, has significant soil erosion issues. To examine the effects of LUCC on water erosion, we studied the LUCC in Sarada, Rapti and Thuli Bheri river basins of Nepal during the 1995-2015 period using the Remote Sensing.

Serum sHLA-G: Significant diagnostic biomarker with respect to therapy and immunosuppressive mediators in Head and Neck Squamous Cell Carcinoma.

Head & Neck Squamous Cell Carcinoma is one of the highest mortality factors in the world due to the lack of potential biomarker for early detection of disease. There is an urgent need for molecular marker involved in disease progression which remains suppressed normally, required for specificity. HLA-G is highly expressed in cancers and creates immune-suppressive microenvironment.

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in model of Parkinson's disease.

Insulin-signalling is an important pathway in multiple cellular functions and organismal ageing across the taxa. A strong association of insulin-signalling with Parkinson's disease (PD) has been proposed but the exact nature of molecular events and genetic associations are yet to be understood. We employed transgenic strain harboring human α-synuclein::YFP transgene, towards studying the aggregation pattern of α-synuclein, a PD-associated endpoint, under human insulin (Huminsulin®) treatment and DAF-16/DAF-2 knockdown conditions, independently and in combination.

Techno-economic analysis for extracellular-polymeric substances (EPS) production using activated sludge fortified with crude glycerol as substrate and its application in leachate treatment.

Economic assessment of bio-flocculant production process has been carried out by SuperPro Designer where extracellular-polymeric substances (EPS) were produced using activated sludge fortified with crude glycerol in fermenter followed by centrifugation. Considering EPS concentration of 60 g/L in production fermenter at 96 h, the unit production cost for slime EPS was estimated to be $ 0.95/L.

A clinicopathological study of granulosa cell tumors of the ovary: Can morphology predict prognosis?

Objective: Granulosa cell tumors (GCT) are low-grade malignant sex cord-stromal tumors (SCST) with late metastasis/recurrences and long disease-free periods. We performed a clinicopathological evaluation of GCT to ascertain features having prognostic impact.

Materials And Methods: All cases of GCT of ovary from January 2006 to December 2018 were assessed for architectural patterns, nuclear grooves, and Call-Exner bodies.

Central line-associated bloodstream infections in cancer patients: An experience from a tertiary care cancer centre.

Introduction: Central venous catheters (CVCs) implanted in patients with malignancies may often be associated with local or central line-associated bloodstream infections (CLABSI), which are a major source of morbidity and rarely mortality, making such patients' care difficult and complicated.

Materials And Methods: This retrospective study is a single-centre's experience including both paediatric and adult patients with malignancy, who had a CVC inserted and were receiving care at cancer centre of our hospital over a period between January 2017 and June 2018.

Results: In the period from January 2017 to June 2018, 73 confirmed cases of CLABSIs among cancer patients were included in this study.

Short-Term Impact of Hematopoietic Stem Cell Transplantation on Psychiatric Morbidity and Quality of Life in Hematological Malignancies in Adults.

Background: Hematopoietic stem cell transplantation (HSCT) is an established treatment for a number of malignancies. Quality of life (QOL) is an important marker for assessing arduous treatment modalities. Diagnosis of cancer, HSCT, and the physical and psychosocial sequelae of the intensive treatment lead to a deficit in the QOL of the recipient.

Citrate combustion synthesized Al-doped CaCuTiO quadruple perovskite: synthesis, characterization and multifunctional properties.

The facile synthesis of the Al-doped CaCuTiO quadruple perovskite, a well-known and vastly studied material for various technological applications, using the modified citrate combustion route along with structural, microstructural, and X-ray photoelectron spectroscopic (XPS) characterization and magnetic, dielectric and electrical properties has been investigated and reported here. The possible applications of the material as a Schottky barrier diode (SBD) in optoelectronic devices and as a catalyst in methanol steam reforming (MSR) reaction for hydrogen generation, hitherto unreported in the open literature, have also been explored. The compound is crystallized in the cubic body centered Im3[combining macron] space group and the particle size is found to be in nanodimension with rather narrow size distribution.

RNA-Seq profiling of deregulated miRs in CLL and their impact on clinical outcome.

Abnormal expression patterns of regulatory small non-coding RNA (sncRNA) molecules such as microRNAs (miRs), piwi-interacting RNAs (piRNAs), and small nucleolar RNAs (snoRNAs) play an important role in the development and progression of cancer. Identification of clinically relevant sncRNA signatures could, therefore, be of tremendous translational value. In the present study, genome-wide small RNA sequencing identified a unique pattern of differential regulation of eight miRs in Chronic Lymphocytic Leukemia (CLL).

Locally advanced cervical cancer - neoadjuvant chemotherapy followed by concurrent chemoradiation and targeted therapy as maintenance: A phase II study.

Aim: The survival in locally advanced cervical cancer remains low. We evaluated the role of neoadjuvant chemotherapy (NACT), chemoradiotherapy (CRT), followed by gefitinib maintenance in locally advanced cervical cancer.

Materials And Methods: Twenty-five patients with locally advanced carcinoma cervix were enrolled between July 2012 and May 2013.

Bioconversion of waste (water)/residues to bioplastics- A circular bioeconomy approach.

Research insight into the technical challenges of bioplastics production has revealed their confoundedness in their niche markets and struggles to enter the mainstream. There is an increasing problem of waste disposal and high cost of pure substrates in polyhydroxyalkanoates (PHA) production. This has led to the future need of upgrading the waste streams from different industries into the role of feedstocks for production of PHA.

Modeling reservoir management for malaria control in Ethiopia.

This study investigated how changes in reservoir water level affect mosquito abundance and malaria transmission in Ethiopia. Digital elevation models of three Ethiopian dams at lowland, midland and highland elevations were used to quantify water surface area and wetted shoreline at different reservoir water levels (70, 75, 80, 85, 90, 95 and 100% full capacity) to estimate surface area of potential mosquito breeding habitat. Reservoir water level drawdown rates of 10, 15 and 20 mm.

Meteorological data and farmers' perception of coastal climate in Bangladesh.

This study compares the scientifically observed spatiotemporal climate variability with farmer perceptions. A survey of 381 farmers and ten focus group discussions (FGDs) were used to collect data from ten coastal subdistricts. We hypothesized that any gap between farmer perceptions and meteorological data could be due to variations in their individual characteristics.

Cost, energy and GHG emission assessment for microbial biodiesel production through valorization of municipal sludge and crude glycerol.

In this study, cost simulations were made based on 20 million L blended biodiesel B-10 production per year using INRS and conventional process. In case of INRS process, microbial lipid was produced by T. oleaginosus using washed municipal secondary sludge fortified with crude glycerol while lipid was extracted from wet biomass using biodegradable surfactant and petroleum-diesel (PD).