Targeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide.

Background: Survival rates in Small Cell Lung Cancer (SCLC) remain dismal, posing a huge medical need for novel therapies. T-cells, engineered to express chimeric antigen receptors (CAR-T) have demonstrated clinical activity against a variety of haematological malignancies. Yet, efficacy against solid tumour entities remains limited.

Comparative Analysis of Single-Dose and Multiple-Dose Antibiotic Prophylaxis in Preventing Surgical Site Infections.

Background: Surgical site infections (SSIs) represent a significant challenge following general surgical procedures, affecting approximately 1 in 24 patients undergoing inpatient surgery in the United States. Despite advances in antibiotic therapies and antiseptic techniques, SSIs continue to impact surgical outcomes. Effective prophylactic antibiotic administration is critical for reducing SSI rates.

‑Heterocyclic Carbene-Based Group 4 Catalysts for the Terpolymerization of Cyclohexene Oxide and Cyclic Anhydrides with CO.

A series of bis-phenolate saturated -heterocyclic carbene (NHC) group 4 complexes ([κ-O,C,O]-NHC)-M-(OPr)-Cl-(THF) (M = Ti, ; Zr, ; Hf, ) in the presence of [PPN]Cl as cocatalyst were investigated and showed high activity in the tandem terpolymerization of phthalic anhydride (PA), cyclohexene oxide (CHO) with CO. The resultant terpolymers revealed a diblock pattern leading selectively to poly-(ester--carbonate). Subsequently, other titanium complexes ([κ-O,C,O]-NHC)-TiX bearing various coligands (X = Cl, ; OPr, ; OAc, ; OAc, ) also displayed high activity with a turnover frequency (TOF) up to 460 h that is comparable to .

Identification of gray leaf spot-resistant donor lines in tropical maize germplasm and their agronomic performance under artificial inoculation.

Gray leaf spot (GLS) disease is caused by two fungal pathogens, and . The current study evaluated 427 elite tropical/subtropical lines for their responses to GLS under artificial inoculation in Kakamega in western Kenya for 4 years. Furthermore, a subset of 140 lines was used for a high-resolution genome-wide association study (GWAS) for GLS resistance.

Evaluating the therapeutic potential of tofacitinib in Sjögren's disease: a comprehensive clinical and immunological assessment.

Objective: To evaluate the efficacy, safety, and immunological effects of tofacitinib in patients with Sjögren's Disease (SjD), focusing on its impact on disease activity and immune cell modulation.

Methods: Two independent cohort studies, one retrospective (Cohort I) and one prospective (Cohort II), were conducted to investigate the efficacy of oral tofacitinib treatment in patients diagnosed with SjD. All participants were evaluated for changes in disease activity and lab parameters.