Association of Omeprazole-Related Myopathy With Drug-Drug and Drug-Gene Interactions Involving CYP2C19 and CYP3A4: A Nested Case-Control Study.

Background: Omeprazole, a widely used proton pump inhibitor, has been associated with rare but serious adverse events such as myopathy. Previous research suggests that concurrent use of omeprazole with fluconazole, a potent cytochrome P450 (CYP) 2C19/3A4 inhibitor, may increase the risk of myopathy. However, the contribution of genetic polymorphisms in CYP enzymes remains unclear.

Clinical Outcomes of Congenital Hypothyroidism Due to Biallelic Mutations after Levothyroxine Withdrawal.

is a major cause of congenital hypothyroidism (CH) in Chinese patients, but clinical outcomes for those with biallelic mutations remain unclear. This study aimed to describe the clinical manifestations of CH due to defect. One hundred eighty-one patients with primary CH were recruited initially and were subjected to genetic screening.

A novel label-free NIR aptasensor based on triphenylmethane dyes for rapid detection of salicylic acid.

Salicylic acid (SA) is a critical phytohormone involved in plant growth, development, and defense responses, making its precise quantification essential for both agricultural management and environmental monitoring. Here, we report a novel label-free near-infrared aptasensor (NIRApt) for the rapid and sensitive detection of SA, utilizing a rationally selected triphenylmethane (TPM) dye. Through systematic screening, ethyl violet (EV) was identified as the optimal fluorophore, showing pronounced fluorescence enhancement upon binding to a SA-specific aptamer.

[β-sitosterol, an important component in the fruits of Miq., prolongs lifespan of by suppressing the ferroptosis pathway].

Objectives: To elucidate the anti-aging effect of β-sitosterol (BS), an important component in the fruits of Miq., in and its regulatory effect on ETS-5 gene to modulate ferroptosis.

Methods: treated with 10 µg/mL BS were monitored for survival time and changes in body length, motility, and reproductive function.

Comparison of clinical manifestations, antimicrobial susceptibility patterns, and carbapenem resistance determinants between Acinetobacter seifertii and Acinetobacter nosocomialis isolated in Taiwan.

Background: Acinetobacter seifertii, a recently identified member of the Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex, has emerged as a cause of severe human infections. It is closely related to Acinetobacter nosocomialis, a major pathogen of the Acb complex. Here, we aimed to explore the clinical and molecular differences between these two species.