Publications by authors named "Kuan-Yu Pan"

Objectives: Person-related work requires workers to interact with individuals not employed at the workplace, such as clients and patients, and can cause emotional labour and conflict. These stressors may increase workers' risk of type 2 diabetes, but their impact may differ depending on the level of support received from colleagues. We aimed to examine the association between person-related work and the risk of type 2 diabetes, and the effect modification of social support at work.

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Person-related work requires interaction with individuals not employed at the workplace, such as clients and patients, and can result in emotional labour, emotional demands, and confrontation. These stressors may increase workers' risk of cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke, whereas colleagues' support may help buffer their impact. We aimed to examine the association between person-related work and the risk of CVD, and effect modification of social support at work.

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Article Synopsis
  • Individual participant data (IPD) meta-analysis allows for better understanding of interaction and effect modification compared to traditional studies, especially in public health contexts.
  • The text emphasizes the importance of focusing on additive interactions rather than just multiplicative ones, particularly using measures like Relative Excess Risk due to Interaction (RERI).
  • A three-step method is proposed to correctly estimate additive interaction across studies, ensuring valid results when analyzing factors like the link between depression, smoking, and cancer risk using available data.
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Purpose: Though individuals with depression and those with poor working conditions are more likely to be on long-term sickness absence (LTSA), less is known about how working conditions may modify the associations between depression status and LTSA. This study aims to examine the association between depression and LTSA among Swedish workers with different levels of job strain and its individual components (job demands and job control).

Methods: All Swedish workers 30 - 60 years old (N = 3,065,258) were studied in 2005.

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RNA-Sequencing (RNA-Seq) and transcriptomic analyses have become powerful tools to study the developmental stages of fungal structures scuh as sclerotia. While RNA-Seq experiments have been set up for many important sclerotia- and microsclerotia-forming fungi, it has not been implemented to study , which is one of the earliest fungi used in literature to uncover the roles of reactive oxygen species (ROS) in stimulating sclerotia formation. This study applied RNA-Seq to profile gene expression in four developmental stages of sclerotia.

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Article Synopsis
  • The study investigates how health behaviors like smoking, physical inactivity, and alcohol use may mediate the relationship between depression, anxiety, and different types of cancer, including lung and breast cancer.
  • Utilizing data from 18 cohorts with a total of 319,613 participants, the researchers performed two-stage meta-analyses to analyze these associations and calculate the mediating effects.
  • Results showed that smoking and physical inactivity significantly mediated links between depression, anxiety, and lung cancer, highlighting the importance of smoking cessation programs for individuals dealing with mental health issues.
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Background: Little is known about common mental disorders (CMD) diagnoses among social workers, i.e., depression, anxiety, or stress-related disorders.

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Objectives: This study aims to investigate the extent to which low job control and heavy physical workload in middle age explain educational differences in all-cause and ischemic heart disease (IHD) mortality while accounting for important confounding factors.

Methods: The study is based on a register-linked cohort of men who were conscripted into the Swedish military at around the age of 18 in 1969/1970 and were alive and registered in Sweden in 2005 (N=46 565). Cox proportional hazards regression models were built to estimate educational differences in all-cause and IHD mortality and the extent to which this was explained by physical workload and job control around age 55 by calculating the reduction in hazard ratio (HR) after adjustments.

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Article Synopsis
  • The study investigates the role of psychosocial factors, like depression and anxiety, in how health behaviors (such as smoking and alcohol use) influence cancer incidence.
  • Utilizing data from 437,827 participants and 22 cohorts, researchers performed meta-analyses to assess potential interactions between psychosocial factors and health behaviors across various types of cancer.
  • Results showed no significant interactions or clear patterns; the risk of cancer linked to health behaviors appeared consistent regardless of the presence of psychosocial stress.
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Article Synopsis
  • Psychosocial working conditions, such as job demands and control, are linked to well-being before retirement, with a study of 598 individuals aged 60-65 revealing varying impacts.
  • High job control and high job demands correlate with better well-being, while passive and high strain jobs are linked to lower well-being, particularly in men.
  • Engagement in leisure activities can influence this relationship, with high leisure activities helping mitigate the negative effects of passive work, and low leisure activities exacerbating the impact of high strain jobs.
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Article Synopsis
  • Depression and anxiety have been studied as potential risk factors for various types of cancer, but previous research has produced inconclusive results.
  • The PSY-CA consortium analyzed data from 18 cohorts, including over 319,000 participants, to investigate the relationship between these mental health conditions and cancer incidence using detailed statistical methods.
  • The findings revealed no significant links between depression or anxiety and most cancer types, although there was a slight association with lung and smoking-related cancers, which diminished after accounting for other risk factors like smoking and alcohol consumption.
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Purpose: Many studies report about risk factors associated with adverse changes in mental health during the COVID-19 pandemic while few studies report about protective and buffering factors, especially in older adults. We present an observational study to assess protective and buffering factors against COVID-19 related adverse mental health changes in older adults.

Methods: 899 older adults (55 +) in the Netherlands were followed from 2018/19 to two pandemic time points (June-October 2020 and March-August 2021).

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Background: The differential impact of depression across different periods in life on mortality remains inconclusive. We aimed to examine the association of depression that occurs at different age with all-cause mortality, and to explore the roles of dementia, as well as genetic and early-life environmental factors, in this association.

Methods: From the Swedish Twin Registry, 44,919 twin individuals were followed for up to 18 years.

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Article Synopsis
  • Mental health in adults experienced only modest changes during the early COVID-19 pandemic, but individual experiences varied widely.
  • The study analyzed data from 1517 Dutch participants to identify factors (like neuroticism, living situation, gender, and adherence to restrictions) that influenced differences in mental health outcomes such as depression, anxiety, and loneliness.
  • Key findings highlighted that higher neuroticism, living alone, and strict adherence to COVID-19 restrictions were linked to worsened mental health, while teleworking and older age showed some protective effects.
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Background Although sleep disorders have been linked to cardiovascular diseases (CVDs), the association between sleep characteristics and CVDs remains inconclusive. We aimed to examine the association of nighttime sleep duration, daytime napping, and sleep patterns with CVDs and explore whether genetic and early-life environmental factors account for this association. Methods and Results In the Swedish Twin Registry, 12 268 CVD-free twin individuals (mean age=70.

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Introduction: The impact of life-course traumatic brain injury (TBI) on dementia is unclear.

Methods: Within the Swedish Twin Registry (STR), 35,312 dementia-free twins were followed for up to 18 years. TBI history was identified via medical records.

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Background: The coronavirus disease 2019 (COVID-19) pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare.

Methods: In a stratified random sample of the German household population ( = 6684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress [(PD; measured via Patient Health Questionnaire for Depression and Anxiety (PHQ-4)] from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points.

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Background: Little is known about the longer-term impact of the Covid-19 pandemic beyond the first months of 2020, particularly for people with pre-existing mental health disorders. Studies including pre-pandemic data from large psychiatric cohorts are scarce.

Methods: Between April 2020 and February 2021, twelve successive online questionnaires were distributed among participants of the Netherlands Study of Depression and Anxiety, Netherlands Study of Depression in Older Persons, and Netherlands Obsessive Compulsive Disorder Association Study (N = 1714, response rate 62%).

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Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.

Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology.

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Introduction: The impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies.

Methods: Within the Rush Memory and Aging Project, 1588 dementia-free participants were assessed on FGCRS at baseline and followed up to 21 years.

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Background: this article investigates the association between life satisfaction and disability-free survival, and explores the roles of chronic diseases and healthy lifestyle in this association.

Method: a cohort of 2,116 functionally independent adults aged ≥60 was followed up to 12 years. At baseline, life satisfaction was assessed with the Life Satisfaction Index A (LSI-A).

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Synopsis of recent research by authors named "Kuan-Yu Pan"

  • - Kuan-Yu Pan's research focuses on integrating psychosocial factors, health behaviors, and job strain in understanding mental health outcomes and their association with chronic conditions, particularly cancer and depression.
  • - Recent studies by Pan highlight the importance of additive interaction in individual participant data meta-analysis, investigating how psychosocial elements interact with health behaviors in cancer incidence, and the mediating role of health behaviors between mental health issues like depression and anxiety, and cancer risk.
  • - Additionally, Pan's work delves into the effects of job strain on the relationship between mental health and long-term sickness absence among workers, underscoring the significance of working conditions in shaping health disparities across different educational backgrounds.