Publications by authors named "Erik J Giltay"

ObjectiveTo evaluate the psychometric characteristics of a previously validated electronic headache diary with automated algorithm for the purpose of identifying migraine days.MethodsThe psychometric properties of 13 variables in this e-diary were analyzed using item response theory (IRT) in migraine patients from the Leiden Headache Center. The included items were headache presence, duration, unilaterality, severity, pulsating, aggravation by physical activity, visual aura, aura duration, nausea, vomiting, photophobia or phonophobia and triptan usage.

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Introduction: Physical activity (PA) decreases the risk of mental diseases. Although PA timing has been hypothesised to affect mental health outcomes, no large-scale epidemiological cohort studies have been performed. We investigated the association between PA timing and incident depression in the general population.

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A more inclusive approach for addressing the diverse spectrum of mental health experiences is needed. Network theory frames psychopathological complaints as complex dynamic systems, that can be modelled in a network of mutually interacting symptoms. These networks may provide important markers of symptom improvement or exacerbation, and inform strategies for early intervention and treatment.

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Objectives: Contemporary public health and care policies expect that promoting self-reliance can help older adults prevent or recover from morbidity, including psychiatric disorders. We sought to clarify the role of self-reliance dynamics in developing and recovering from psychiatric symptoms throughout the aging process.

Method: We used dynamic time warping to analyze the temporal ordering of within-person changes in five self-reliance indicators (three self-efficacy dimensions, mastery, self-esteem) and psychiatric symptoms in  = 1968 participants aged 55+ in the Longitudinal Aging Study Amsterdam, measured up to ten times across up to 30 years.

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Background: Dysregulated stress reactivity has been closely linked to psychopathology. However, most studies have applied cross-sectional lab-based methodologies rather than longitudinal designs, like ecological momentary assessment (EMA). EMA provides dynamic, time-sensitive data that require advanced analytical approaches.

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Background: The striking link between Cushing's syndrome, the metabolic syndrome (MetS), and cardiovascular disease suggests that long-term exposure to high glucocorticoid levels catalyzes cardiometabolic deterioration. However, the relation of subtle variations in long-term glucocorticoid levels with MetS remains poorly understood. Specifically, little is known about potential moderating roles of age, sex and mental health status in this association.

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Objectives: This study aimed to identify trajectories of core depressive symptoms and insomnia symptoms in depressed older adults, their prevalence and association, and predictors of unfavorable trajectories.

Method: We examined 6-year follow-up data of 329 depressed older adults from the Netherlands Study of Depression in Older persons. Core depressive symptoms and insomnia symptoms were assessed with the Inventory of Depressive Symptomatology.

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Understandings of psychotrauma have changed throughout medical history, shaped by cultural and social factors. Reviewing transcultural perspectives of psychotrauma helps understand its complexities and contextual impacts. This paper summarizes the Japan-Netherlands symposium on psychotrauma held on March 1, 2024.

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Background: Major depressive disorder (MDD) and anxiety disorders (AD) have high degrees of comorbidity and show great overlap in symptoms. The analysis of covarying depressive- and anxiety symptoms in longitudinal, sparse data panels has received limited attention. Dynamic time warping (DTW) analysis may help to provide new insights into symptom network properties based on diagnostic- and disease-state stability criteria.

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Background: Although childhood trauma is an important risk factor for various diseases, the underlying biological mechanisms remain insufficiently understood. To deepen this understanding, we investigated the wide-spectrum metabolomic signature of childhood trauma exposure in a large adult cohort.

Methods: Baseline and 6-year follow-up data from NESDA (Netherlands Study of Depression and Anxiety) were used (N = 2902, N = 4800).

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Use of standardised scores, such as T-scores and percentile rank order scores, enhances measurement-based care. They facilitate communication between therapists and clients about test results, particularly for multidimensional measures such as the Symptoms Questionnaire (SQ-48). By transforming raw scores into a common metric, clinicians can more easily interpret and discuss patient profiles of scores on the various scales of the measure.

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Background: The prevalence of depressive symptoms, apathy, and cognitive decline increases with age. Understanding the temporal dynamics of these symptoms could provide valuable insights into the early stages of cognitive decline, allowing for more timely and effective treatment and management.

Methods: Participants from the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial cohort with baseline and ≥3 follow-up measurements were included, with a median of 7.

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Background: Bidirectional interactions between immune and neuroendocrine mechanisms are involved in mood and psychotic disorders, although individual studies report inconsistent and even contradictory findings on the nature of this crosstalk. Our objective was to perform an up to date systematic review and meta-analysis of the association between hypothalamic-pituitary-adrenal (HPA) axis and immune system functioning in mood and psychotic disorders.

Methods: We searched the Pubmed, Web of Science and Embase databases for studies reporting correlations between one or more HPA- and immune markers (IM) in patients with mood or psychotic disorders.

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Functional ageing, related to but distinct from biological and environmental systems, is defined as the changes in physical, psychological, cognitive, and social functioning, as well as behavioural factors of individuals as they age. In this Personal View, we propose that a complex systems perspective to functional ageing can show how outcomes such as quality of life and longevity, and success in prevention and treatment, emerge from dynamic interactions among these domains, rather than from single causes. We support this view in three ways.

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Article Synopsis
  • Adverse childhood experiences (ACEs) are linked to long-term mental health issues like PTSD, and are notably more common in military personnel who must preserve mental health for their duties.
  • A study with 752 recruits from the Japan Air Self-Defense Force found that self-compassion, which involves treating oneself kindly, significantly reduces PTSD symptoms and is negatively impacted by ACEs.
  • The research indicated that self-compassion only partially mediates the relationship between ACEs and PTSD symptoms, suggesting the need for further studies to develop educational programs aimed at increasing self-compassion in individuals with ACEs to help lessen PTSD symptoms.
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  • A study examined the emotional and skin-related symptoms in five patients with cutaneous T-cell lymphoma undergoing glucocorticoid treatment, finding that emotional disturbances often accompany this therapy.
  • Results showed that as treatment progressed, positive emotions declined, leading to increased irritation and itchy skin the following day.
  • The findings suggest that reduced positive emotions at the end of glucocorticoid treatment may be linked to lower energy and motivation, potentially worsening skin-related issues.
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  • Depression is typically viewed as a disease caused by a common factor, but this study takes a network approach, focusing on how individual symptoms influence each other and their dynamics over time.
  • Using the Symptom Questionnaire-48 (SQ-48), researchers examined patient data with dynamic time warp analyses, discovering significant interconnections between various symptoms and how certain symptoms led to changes in others.
  • The study identified five symptoms ('hopeless', 'restless', 'down/depressed', 'feeling tense', and 'no enjoyment') that could be targeted for more effective, personalized treatments, though the focus on severely depressed inpatients limits the generalizability of the findings.
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Importance: Peacekeepers in United Nations missions experience potentially traumatic events, resulting in increased risk for posttraumatic stress disorder (PTSD). Understanding the course and risk factors of PTSD symptom severity is crucial to ensure personnel safety.

Objective: To investigate the incidence of PTSD, symptom severity trajectories, and potential risk factors associated with adverse trajectories among Japanese peacekeepers deployed in South Sudan.

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Background: Childhood trauma, including emotional neglect, emotional abuse, physical abuse, and sexual abuse, may contribute to borderline personality features like affective instability, identity problems, negative relationships, and self-harm. This study aims to explore how different types of childhood trauma affect these features in bipolar versus unipolar depressive disorders.

Methods: We included 839 participants of the Netherlands Study of Depression and Anxiety (NESDA) with a lifetime diagnosis of major depressive disorder single episode (MDDS; N = 443), recurrent major depressive disorder (MDD-R; N = 331), or bipolar disorder (BD; N = 65).

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Background: Recovery processes during residential treatment for eating disorders, especially in patients with a history of maltreatment, are insufficiently understood. This study aimed to explore the temporal relationships among comorbid factors, including depression, anxiety, and self-compassion, with the influence of childhood maltreatment.

Method: Using Dynamic Time Warp (DTW), weekly scores from the Symptom Checklist-5, Eating Disorder Examination, and Self-Compassion Scale were analysed over 12 weeks.

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Background: The prevalence of depressive symptoms and cognitive decline increases with age. We investigated their temporal dynamics in individuals aged 85 and older across a 5-year follow-up period.

Methods: Participants were selected from the Leiden 85-plus study and were eligible if at least three follow-up measurements were available (325 of 599 participants).

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Background: Persistent depressive disorder (PDD) is prevalent and debilitating. For patients with PDD, psychiatric rehabilitation using self-management interventions is advised as the next therapeutic step after multiple unsuccessful treatment attempts. The "Patient and Partner Education Program for All Chronic Diseases" (PPEP4All) is a brief, structured self-management program that focuses on functional recovery for patients and their partners/caregivers.

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