Publications by authors named "Kuan-Chen Lu"
J Biomed Inform
July 2023
Article Synopsis
- Genotype imputation is important for understanding disease variants in Asian populations, which have been underrepresented in genetic studies compared to Caucasian populations.
- A new web platform called Multi-ethnic Imputation System (MI-System) has been developed to facilitate easy genotype imputation for East-Asians, providing multiple established pipelines and a unique reference panel for Taiwanese-Chinese ancestry.
- MI-System allows researchers to upload their data for imputation with minimal effort, contributing to faster research in Asian population genetics without needing extensive computational resources or bioinformatics expertise.
Front Cardiovasc Med
October 2021
Article Synopsis
- - The study focuses on assessing cardiovascular mortality risk in an aging population through a combined score based on electrocardiographic (ECG) parameters, aiming for primary prevention strategies.
- - Conducted on over 5,300 elderly subjects in Taiwan, results showed that specific ECG abnormalities like left ventricular hypertrophy (LVH) and prolonged QTc and PR intervals were significantly linked to all-cause and cardiovascular death.
- - The research developed predictive models using an ECG abnormality score, which effectively identified high-risk groups, demonstrating robust statistical improvements in predicting outcomes related to mortality.
