Potential for prolonged replication of common acute respiratory viruses in air-liquid interface cultures of primary human airway cells.

Unlabelled: A previous study provides clinical evidence that extended respiratory virus detection can occur in healthy pediatric individuals. However, it remains unclear how long respiratory viruses can survive in the human respiratory tissue. In this study, the replication potential of common respiratory viruses was evaluated using air-liquid interface (ALI) cultures of primary human respiratory epithelial cells.

Respiratory Syncytial Virus Fusion Protein Epitope-specific Antibodies and Neutralizing Activities against Various Respiratory Syncytial Virus Strains.

Background: Respiratory syncytial virus (RSV) F protein contains major neutralizing epitopes, including sites Ⅱ, Ⅲ, Ⅳ, Ⅴ, and Ø, which are the targets of newly developed vaccines and monoclonal antibodies. However, data on serum epitope-specific antibodies (ESAs) and their association with neutralizing activity (NA) are limited. Hence, in the current study, we aimed to evaluate ESA levels in healthy Japanese adults and their association with NA levels against various clinical isolates.

Product Engagement Detection Using Multi-Camera 3D Skeleton Reconstruction and Gaze Estimation.

Product engagement detection in retail environments is critical for understanding customer preferences through nonverbal cues such as gaze and hand movements. This study presents a system leveraging a 360-degree top-view fisheye camera combined with two perspective cameras, the only sensors required for deployment, effectively capturing subtle interactions even under occlusion or distant camera setups. Unlike conventional image-based gaze estimation methods that are sensitive to background variations and require capturing a person's full appearance, raising privacy concerns, our approach utilizes a novel Transformer-based encoder operating directly on 3D skeletal keypoints.

Labor epidural analgesia and autism spectrum disorder in 3-year-old offspring based on data from the Japan Environment and Children's Study: a prospective cohort study.

Objective: To evaluate the association between labor epidural analgesia (LEA) and autism spectrum disorder (ASD) in 3-year-old offspring in Japan.

Methods: Prospective cohort study utilizing the Japan Environment and Children's Study, the largest nationwide birth cohort study. A total of 65,742 live singleton offspring were enrolled between January 2011 and March 2014.

A randomized, placebo-controlled phase III trial of an autologous, formalin-fixed tumor vaccine for newly diagnosed glioblastoma: trial protocol.

Unlabelled: This multi-institutional, double-blind, randomized, placebo-controlled phase III trial was designed to evaluate the efficacy and safety of Cellm-001, an autologous formalin-fixed brain tumor immunostimulant, for newly diagnosed glioblastoma with gross total resection to prolong overall survival (OS) and prevent recurrence after surgery. One hundred twelve patients are to be randomized 1:1 to either Cellm-001 with standard chemoradiotherapy (CRT) or saline solution with standard CRT. Randomization is based on the following stratified randomization criteria: age, Karnofsky Performance Status, and the presence or absence of photodynamic therapy (PDT).

Association between umbilical cord arterial pH and neurodevelopment of offspring at the age of 3 years: The Japan environment and Children's study.

Objective: To evaluate the association between umbilical cord pH at birth and neurodevelopment in 3-year-old offspring.

Methods: In this prospective cohort study, we identified 71 680 term deliveries in Japanese women recruited to the Japan Environment and Children's Study (JECS) between January 2011 and March 2014. Data on singleton pregnancies involving live-term births between 2011 and 2014 were extracted from the JECS database.

Urinary cotinine levels versus self-reported smoking status for assessing placental abruption risk: the Japan Environment and Children's study.

Introduction: Placental abruption is a serious complication of pregnancy, and smoking is a well-known risk factor thereof. However, evaluations of the effects of smoking mostly rely on self-reported questionnaires, resulting in incorrect representation of smoke exposure owing to incorrect reporting and missing data on passive smoking. Cotinine is a major nicotine metabolite and a sensitive biomarker in smokers.

Changes in peripheral blood test results among adults in the six years following the Great East Japan Earthquake: the Fukushima Health Management Survey.

The Fukushima Health Management Survey, conducted by Fukushima Prefecture since the 2011 Great East Japan Earthquake (GEJE), has not identified any health effects from radiation exposure.　Complete blood counts (CBC), which are sensitive to radiation exposure, have not shown lymphocytopenia, neutropenia, anemia, or thrombocytopenia, but the white blood cell fractions have not yet been analyzed since 2011.　We classified 25,885 residents (11,383 male, 14,502 female;age range, 16-84 years) in evacuation areas with external exposure dose estimates based on behavioral surveys conducted 4 months after the GEJE into two groups (0-1 [≥0 and <1] and ≥1 mSv) and analyzed changes in CBC and leukocyte fractions from fiscal year (FY) 2011 to FY2017 and their influencing factors.

Association between timing of exanthema subitum and febrile seizures: The Japan environment and children's study.

Recently, episodes of exanthema subitum (ES) have been occurring later than expected in Japanese patients, though the effects of this delayed timing remain unclear. Therefore, this study examined the association between ES timing and febrile seizure (FS) in Japanese children. Information on the diagnoses of ES and FS was obtained from the Japan Environment and Children's Study, a nationwide prospective birth cohort study including 97,410 mothers and their children.

Association between the duration of mothers' digital media use while with their children and two-year-old children's development from the Japan Environment and Children's Study.

Few studies have evaluated the association between the duration of mothers' digital media use (including mobile phones, tablets, and PCs) while with their children and children's development. Using data from the Japan Environment and Children's Study, we explored this relationship through multiple regression analysis. Self-administered questionnaires measured the duration of mothers' digital media use.

Trends in Efficacy Endpoints in Phase II Glioblastoma Trials: A Regulatory Science Analysis (FY2020-FY2022).

: In glioblastoma trials, efficacy evaluation often deviates from the standard Response Evaluation Criteria in Solid Tumors (RECIST), an objective response rate (ORR) method, because of the unique nature of brain tumors. In phase II trials from the fiscal years (FYs) 2017-2019, primary endpoints (PEs) were overall survival (OS) at 29%, ORR at 20%, progression-free survival (PFS) at 17%, and OS rate at 10%. Clinical trial methodologies have likely evolved in recent years.

Impact of cord blood cadmium concentration on neonatal secondary sex ratio: The Japan Environment and Children's Study.

The secondary sex ratio (SSR) is the male-to-female birth ratio per 100 female births, typically slightly favoring males. Recent declines in SSR suggest environmental factors, such as cadmium (Cd), may contribute. While cadmium is harmful to human health, its impact on SSR is unclear.

A Clinical Isolate of Human Parainfluenza Virus 3 (Fukushima/O695/2019) Contains a Mutation in the Serial Guanosines in the RNA Editing Site of the P Gene and Produces an Atypical Number of Nongenomic Guanosine Insertions During RNA Editing.

Human parainfluenza virus 3 (HPIV3) contains a purine-rich RNA editing site, allowing multiple viral proteins to be produced from a single gene by the posttranscriptional addition of G nucleotides. The Fukushima/O695/2019 (O695) HPIV3 clinical isolate has a G-to-A substitution at the last position of five serial G residues in the RNA editing site. This study evaluates the effects of this substitution in the RNA editing site on the biological character of HPIV3.

Relationship between preconception protein intake and gestational diabetes mellitus: The Japan Environment and Children's Study.

Aims: To investigate the relationship between preconception protein intake and the risk of gestational diabetes mellitus (GDM).

Methods: We analyzed data from the Japan Environment and Children's Study, focusing on 80,346 participants (mean age 31.3 ± 4.

Effects of β-glucans on fatigue: a systematic review and meta-analysis.

Several clinical trials suggest that β-glucans may reduce feelings of fatigue, however the results of clinical trials are inconsistent. Additionally, no systematic reviews or meta-analyses have assessed the effects of β-glucans on fatigue. Therefore, this study investigates the effects of β-glucans on fatigue in healthy subjects through a systematic review and meta-analysis.

Pre-pregnancy body mass index and lactational mastitis: The Japan Environment and Children's Study.

Purpose: The association between maternal physique and prevalence of lactational mastitis (LM) in a large study population has not been reported. In this study, we aimed to evaluate the association between pre-pregnancy body mass index (BMI) and LM prevalence.

Methods: We analyzed data collected from participants enrolled in the Japan Environment and Children's Study, a nationwide birth cohort study conducted between 2011 and 2014.

Amino Acid Substitutions in the Fusion Protein of Respiratory Syncytial Virus in Fukushima, Japan, During 2008-2023 and Their Effects.

Background: Amino acid (AA) substitutions in the fusion (F) protein of respiratory syncytial virus (RSV) and their effects on antibody susceptibility remain unclear. We analyzed AA substitutions in the main neutralizing epitopes of the F protein.

Methods: We analyzed F protein genes of 236 RSV strains isolated from children hospitalized with RSV infection in Fukushima, Japan (June 2008-February 2023).

Garment Recognition and Reconstruction Using Object Simultaneous Localization and Mapping.

The integration of robotics in the garment industry remains relatively limited, primarily due to the challenges in the highly deformable nature of garments. The objective of this study is thus to explore a vision-based garment recognition and environment reconstruction model to facilitate the application of robots in garment processing. Object SLAM (Simultaneous Localization and Mapping) was employed as the core methodology for real-time mapping and tracking.

Na[NiMnFeTi]O as an Optimized O3-Type Layered Oxide Positive Electrode Material for Sodium-Ion Batteries.

Layered oxides, such as NaMeO (Me = transition metal, = 0-1), are believed to be the most promising positive electrode materials for Na-ion batteries because of their high true density, large capacities, high working potentials, and reversibility. This study identified Na[NiMnFeTi]O as an optimal composition for use as an O3-type positive electrode material in Na-ion batteries on the basis of a comprehensive phase diagram, where the end members of the triangular phase diagram were Na[NiMn]O, Na[NiTi]O, and the hypothetical composition Na[NiFe]O. By investigating the effects of the partial substitution of Mn with Fe and Ti within the Na[NiMnFeTi]O system, we optimized the capacity, working potential, and cycle performance.

Breastfeeding and Children's Cognitive Development up to the Age of 4 Years: The Japan Environment and Children's Study.

Breastfeeding, depending on its duration, has been suggested to benefit children's cognitive development. We aimed to examine this issue by using the Japan Environment and Children's Study, a nationwide prospective birth cohort study. We evaluated the relationship between feeding methods and cognitive development in 2- and 4-year-old children.

Association between urinary cotinine level and hypertensive disorders of pregnancy in women with uterine myoma: findings from the Japan Environment and Children's Study.

The effect of smoking on hypertensive disorders of pregnancy is a public concern. Recent evidence suggests that the risk of hypertensive disorders of pregnancy is influenced by the presence of uterine fibroids. We explored the association between maternal smoking exposure and the risk of hypertensive disorders of pregnancy in relation to the presence of uterine fibroids using data from Japan's largest birth cohort study.