Dupilumab-induced inhibition of myeloid dendritic cell function via TIM-3-TGF-β1 feedback loop in treatment of atopic dermatitis.

Background: Although clinical trials have demonstrated both the efficacy and safety of dupilumab, its impact on dendritic cells (DCs) remains unclear. T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) has emerged as a crucial regulator of immune responses in various inflammatory diseases. Understanding the interplay between TIM-3 and the type 2 inflammatory response in atopic dermatitis (AD) could provide valuable insights into the mechanisms underlying the efficacy of dupilumab.

Candidalysin induces Tim-3 expression in macrophages to suppress antifungal immunity in oropharyngeal candidiasis.

Oropharyngeal candidiasis significantly impacts patients' quality of life. Although the immune mechanisms underlying OPC have been explored, the roles of immune checkpoints and macrophages in this context remain unclear. We employed single-cell techniques to analyze changes in the oral immune microenvironment and explored the role of Tim-3 in OPC.

Volatile organic compounds exposure associated with skin cancer among U. S. adults: results from NHANES 2011-2018.

Skin cancer, including melanoma, squamous cell carcinoma, and basal cell carcinoma, ranks as the fifth most common cancer globally. It exhibits a high incidence rate, with men being more susceptible, particularly as they age, making middle-aged and older men a high-risk group. This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018 to investigate the relationship between skin cancer and 15 urinary volatile organic compounds (VOC).

GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.

Background: Radiotherapy is a critical treatment modality for nasopharyngeal carcinoma (NPC). However, the mechanisms underlying radiation resistance and tumour recurrence in NPC remain incompletely understood.

Methods: Oxidised lipids were assessed through targeted metabolomics.

Senescence-Related lncRNA Signature Predicts Prognosis, Response to Immunotherapy and Chemotherapy in Skin Cutaneous Melanoma.

Skin cutaneous melanoma (SKCM) is a highly malignant and aggressive cancer. Previous studies have shown that cellular senescence is a promising therapeutic strategy to limit melanoma cell progression. However, models to predict the prognosis of melanoma based on senescence-related lncRNAs and the efficacy of immune checkpoint therapy remain undefined.