The Influence of Mg Doping in α-AlO Crystals Investigated with First-Principles Calculations and Experiment.

The influence of Mg doping in α-AlO crystals is investigated in this article by first-principles calculations and formation energies, density of states, and computed absorption spectra. Three models related to Mg substituting for Al doping structures were constructed, as well as spinel structure models with varying aluminum-magnesium ratios. The formation energy calculations confirmed the rationality of the MgV model, which means that Mg substitutional doping incorporating oxygen vacancies is most likely to form in crystals.

A RADIOLUMINESCENCE STUDY OF DOSE CHARACTERISTICS OF LIF:MG,TI.

A radioluminescence (RL) study of dose characteristics of tissue-equivalent LiF:Mg,Ti was carried out to determine the possible application as a real-time dosemeter. An RL measurements system based on LiF:Mg,Ti coupled with optical fiber was developed, and a blank fiber was set to remove the stem effect generated by the optical fiber due to direct radiation. A slight increase of RL sensitivity with accumulated dose and the afterglow effect due to shallow traps in LiF:Mg,Ti were observed, thus a set of algorithms was adopted to correct measured dose rate.

Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker.

Traditional antitumor drugs such as camptothecin and paclitaxel derivatives are widely used in cancer chemotherapy. However, the major defects of those agents include severe toxicity and poor water solubility. With these in mind, a novel multifunctional linker was designed and two Cathepsin B (CTB) sensitive CPT conjugates (9a and 9b) were synthesized.

Design, synthesis and biological evaluation of C6-modified celastrol derivatives as potential antitumor agents.

New six C6-celastrol derivatives were designed, synthesized, and evaluated for their in vitro cytotoxic activities against nine human cancer cell lines (BGC-823, H4, Bel7402, H522, Colo 205, HepG2 and MDA-MB-468). The results showed that most of the compounds displayed potent inhibition against BGC823, H4, and Bel7402, with IC50s of 1.84-0.