Metabolic effects of chronic exposure to environmentally relevant concentrations of N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) in mice during diet-induced obesity progression.

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) has been detected in edible fish and drinking water, as well as in human serum, raises concerns about the potential health risks. However, there is limited data on the health effects of 6PPD at environmentally relevant doses in mammals. In this study, male C57BL/6J mice were orally exposed to an environmentally relevant dosage of 6PPD (10 ng/kg/day) for fourteen weeks while maintaining on a high-fat, high-fructose (HFHF) diet.

Root and foliar uptake, bidirectional translocation, subcellular distribution, and metabolism of tire wear particle-derived p-phenylenediamines and their quinones in Chinese cabbage and bok choy.

Tire wear particles (TWPs) and TWP-derived compounds have caused global concern for their toxicity, but their impacts on vegetables, particularly through foliar absorption, remain largely unknown. We investigated the absorption, translocation, accumulation, and metabolism of TWP-derived p-phenylenediamines (PPDs) and PPD-quinones (PPDQs) in hydroponic and soil-cultured leafy vegetables by exposing them to TWPs through roots and leaves. PPDs and PPDQs can be absorbed by vegetables through both roots and leaves, with subsequent bidirectional translocation within vegetables.

In-situ biochar amendment mitigates dietary risks of heavy metals and PAHs in aquaculture products.

Heavy metals (HMs) and polycyclic aromatic hydrocarbons (PAHs) are two common contaminant groups of concern in aquaculture products. While biochar amendment can be one of the solutions to immobilize these contaminant in pond sediment, its in situ effectiveness in mitigating the bioavailability, tissue residue, and dietary risk of these contaminants is yet to be tested. In this study, we added wheat straw biochar in sediments of three aquaculture ponds with polyculture of fish and shrimps and employed passive sampling techniques (i.