Association of body composition and cardiovascular fitness with hypertension in a middle-aged adults: a cross-sectional study.

Objectives: This study aims to investigate the association between cardiovascular fitness, body composition (particularly abdominal obesity), and hypertension in middle-aged adults, considering the influence of factors such as age, gender, smoking status and alcohol status.

Methods: A cross-sectional study was conducted among 60 healthy adults (mean aged 54.23 ± 7.

InflammationHypoxia-Inducible Factor Signaling Compensates for Aryl Hydrocarbon Receptor in Maintaining Gut Barrier Integrity.

Background: Inflammatory bowel disease remains an enigma in terms of its etiology, with breakdown of the intestinal barrier attributed to the elusive leaky gut syndrome. In this study, we investigated the role of interplay between hypoxia-inducible factor (HIF) and aryl hydrocarbon receptor (AhR) in maintaining intestinal barrier homeostasis.

Methods: An enteroid system and AhR-deficient mouse models were used, with HIF stabilized by a prolyl hydroxylase inhibitor.

VEGF Signal Complexity Confers Resistance to Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel in EGFR-Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer.

Atezolizumab, bevacizumab, carboplatin, and paclitaxel (ABCP) therapy is beneficial for epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-resistant non-small cell lung cancer (NSCLC); however, the resistance mechanisms are not fully understood. In this study, we conducted a single-cell RNA-sequencing analysis of EGFR-TKI-resistant NSCLC patients grouped into ABCP responders and non-responders. was overexpressed in ABCP responders, whereas was upregulated in non-responders.

Safety of Concomitant Use of Corticosteroids and Traditional Korean Herbal Medicine for Facial Nerve Palsy: A Retrospective Study of Effects on Liver and Renal Function.

Purpose: Bell's palsy is a peripheral neuropathy that requires early administration of high-dose corticosteroids as initial treatment. There is a lack of clinical evidence on the effects of herbal medicines on liver and renal function, as well as their interactions with conventional medicines. This study aimed to assess the safety of using herbal medicine and corticosteroids.

A machine learning platform for genotype-specific cardiotoxicity risk prediction using patient-derived iPSC-CMs.

Introduction: Drug-induced Torsades de Pointes (TdP) has led to withdrawal of several drugs from the market. Individuals with inherited cardiac channelopathies are at increased risk due to their underlying electrophysiological vulnerability.

Objectives: We aimed to develop a machine learning (ML) platform for disease-specific cardiotoxicity using patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) combined with high-throughput microelectrode array (MEA) recordings.

A Digital Software Support Platform for Hyperthyroidism Management in South Korea: Markov Simulation Model-Based Cost-Effectiveness Analysis.

Background: The integration of wearable technology for heart rate monitoring offers potential advancements in managing hyperthyroidism by providing a feasible way to track thyroid function. Although digital health solutions are gaining traction in various chronic conditions, their cost-effectiveness in hyperthyroidism management requires deeper investigation.

Objective: This study aimed to evaluate the cost-effectiveness of a wearable or mobile-based thyroid function digital monitoring solution for hyperthyroidism management and to make a comparison with the existing standard approach within the South Korean health care context.

Long-term management of mandibular osteosarcoma in a dog using toceranib after hemimandibulectomy.

A 6-year-old castrated male golden retriever dog weighing 32.6 kg was presented for chemotherapy after hemimandibulectomy due to mandibular osteosarcoma. Considering the incomplete surgical excision and metastatic potential, adjuvant chemotherapy was considered.

Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation.

Background: Atherothrombosis, the main event leading to acute coronary syndrome (ACS), is strongly linked to disturbed blood flow (d-flow) regions. Although the involvement of the Hippo pathway and its kinases Large Tumor Suppressor Kinase 1and 2 (LATS 1 and 2) in mechanical stress responses is known, the mechanisms by which d-flow simultaneously induces senescence, proliferation, and atherothrombosis remain unclear.

Methods: The role of endothelial cells (EC)-specific LATS1/2 was examined using EC specific knock-out (EKO) mice in a partial left carotid ligation (PLCL) model.

Nano-silicon/reduced graphene oxide composite anodes for high performance all solid-state batteries.

Nano-Si (n-Si) encapsulated with SiO shells and anchored onto reduced graphene oxide (rGO) hydrothermal self-assembly is demonstrated as a promising solid-state battery anode. Compared to simple n-Si, this composite anode exhibited improved rate capability and cycle life, enabled by robust Si-O-C bonding, mechanical reinforcement, and rapid electron transport.

Hypoxic exercise enhances post-exercise hypotension compared to normoxic exercise.

This study aimed to investigate the effect of aerobic exercise under hypoxic conditions (FiO: 14.9%) on post-exercise hypotension compared to normoxic exercise matched for mechanical and physiological intensities. Twenty sedentary men completed three exercise sessions using a crossover design: (1) hypoxic exercise at 50% of peak power output, (2) normoxic exercise at 50% of peak power output (normoxic exercise matched for mechanical intensity), and (3) normoxic exercise with heart rates matched for hypoxic exercise.

Anti-cancer effects of genistein supplementation and moderate-intensity exercise in high-fat diet-induced breast cancer via regulation of inflammation and adipose tissue metabolism in vivo and in vitro.

Background: Breast cancer represents a significant global health concern and is influenced by a range of environmental factors. Increased fat intake and physical inactivity contribute to elevated body fat levels and are strongly linked to breast cancer incidence. Genistein (GEN), isoflavone in soy-derived foods, demonstrates anti-estrogenic properties and anti-cancer effects by regulating various mechanisms such as apoptosis.

Effects of Partial-Body Cryotherapy on Athletic Performance and Sleep Quality in Division I Collegiate Basketball Athletes.

This study examined the effects of short-term partial-body cryotherapy (PBC) on athletic performance and sleep quality in Division I collegiate basketball athletes. A crossover, counter-balanced design was employed with twelve collegiate basketball athletes randomly assigned to five days of a post-exercise PBC condition or a control condition. Athletic performance was assessed using six standardized tests from the Korean Basketball League (KBL) Draft combine.

Connection between trajectory of primary cancer monitoring indicators and mortality after cancer in South Korea.

Background: Cancer remains a leading global cause of mortality, responsible for nearly 10 million deaths in 2020. Given the country's low birth rate and aging population, the escalating cancer burden poses significant challenges to its healthcare systems. This study aimed to investigate the relationship between lifestyle risk factors and cancer case fatality, emphasizing the collective impact of these factors through a prevention index at the regional level.

Bioinspired, Rapidly Responsive Magnetically Tunable Stiffness Metamaterials.

Programmable mechanical materials often require dynamic stiffness adaptability, but existing solutions face challenges with slow response times and limited precision. This study introduces magnetically tunable stiffness metamaterials (MTSM) that utilize a bioinspired ternary programming framework to achieve rapid and precise stiffness modulation. Drawing inspiration from biological sarcomeres, which naturally adjust stiffness through structural changes, the MTSM design employs direct ink writing, a 4D printing method, to incorporate neodymium microparticles and a styrene-isoprene-styrene polymer matrix.

Process development for production of non-originator NISTmAb from CHO and NS0 cell lines.

Cell lines that produce non-originator versions of the National Institute of Standards and Technology (NIST) monoclonal antibody reference material 8671 (NISTmAb) are invaluable to the biopharmaceutical industry because, unlike typical commercial cell lines, they can be used on a collaborative and noncompetitive basis for bioprocess development. NIST has generated NS0 clones, NISTCHO research-grade test material 10197 and reference material 8675 NISTCHO to fill this need. We set out to optimize seed train procedures, media and feeding strategies, and stirred tank and rocking bioreactor processes to facilitate our studies on the effects of cell substrate and bioreactor process parameters on non-originator NISTmAb quality attributes.

A choice based conjoint analysis of mobile healthcare application preferences among physicians, patients, and individuals.

The rapid proliferation of healthcare service applications (apps) makes it challenging for consumers to determine the best one for their needs, prompting the Korean government to introduce an accreditation program to verify app safety. This study aims to identify the factors influencing the choice of healthcare service apps among physicians, patients with chronic diseases, and healthy individuals. We conducted a choice-based conjoint analysis with six factors (number of studies on effectiveness, frequency of information delivery, cybersecurity and data safety, user satisfaction, accreditation, and costs).

Clinical Utility of Patient-Derived Cell-Based In Vitro Drug Sensitivity Testing for Optimizing Adjuvant Therapy in Dogs with Solid Tumors: A Retrospective Study (2019-2023).

Inter-individual variations in drug responses are major concerns in cancer treatment in human and veterinary oncology. Consequently, preclinical models have been proposed to predict drug responses and determine optimal individualized therapy. We aimed to evaluate the clinical utility of in vitro drug sensitivity testing using a patient-derived cell culture model to select appropriate adjuvant therapies for dogs with solid tumors.

Comorbidities associated with adult asthma according to severity: analysis of data from the National Health Insurance Sharing Service.

Background: Asthma is a heterogenous disease having varied phenotypes. The comorbidities associated with asthma vary with age and disease severity. The well-known asthma related comorbid conditions include rhinitis, gastroesophageal reflux disease (GERD), hypertension, obstructive sleep apnea, hormonal disorders, and psychiatric disorders.

Exposure-Response Relationships for Toceranib in Dogs with Solid Tumors: A Pilot Study.

The existence of considerable interpatient variability in pharmacokinetic exposure necessitates dose adjustment to avoid potential adverse events and suboptimal efficacy in targeted therapy. Exposure-response relationships for toceranib phosphate (TOC), the most commonly used tyrosine kinase inhibitor in veterinary oncology, remain unclear. Correlations between TOC exposure and efficacy and safety were evaluated in dogs with solid tumors in our study.

Generation of induced alveolar assembloids with functional alveolar-like macrophages.

Within the human lung, interactions between alveolar epithelial cells and resident macrophages shape lung development and function in both health and disease. To study these processes, we develop a co-culture system combining human pluripotent stem cell-derived alveolar epithelial organoids and induced macrophages to create a functional environment, termed induced alveolar assembloids. Using single-cell RNA sequencing and functional analyses, we identify alveolar type 2-like cells producing GM-CSF, which supports macrophage tissue adaptation, and macrophage-like cells that secrete interleukin-1β and interleukin-6, express surfactant metabolism genes, and demonstrate core immune functions.

Recovery rate and prognostic factors of peripheral facial palsy treated with integrative medicine treatment: a retrospective study.

Introduction: This study aimed to identify prognostic factors and develop a classification model for predicting recovery in patients with peripheral facial palsy.

Methods: Data from patients who received integrative medicine treatment with Bell's palsy and Ramsay-Hunt syndrome were collected. The change of House-Brackmann Grade (HB Grade) for 2 years from the onset and the factors presumed to be related to the prognosis were analyzed by reviewing electrical medical records retrospectively.

Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis.

Background: Atherosclerosis occurs preferentially in the arteries exposed to disturbed flow (d-flow), while the stable flow (s-flow) regions are protected even under hypercholesterolemic conditions. We recently showed that d-flow alone initiates flow-induced reprogramming of endothelial cells (FIRE), including the novel concept of partial endothelial-to-immune-cell-like transition (partial EndIT), but was not validated using a genetic lineage-tracing model. Here, we tested and validated the two-hit hypothesis that d-flow is an initial instigator of partial FIRE but requires hypercholesterolemia to induce a full-blown FIRE and atherosclerotic plaque development.

Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis.

Background: Atherosclerosis occurs preferentially in the arteries exposed to disturbed flow (d-flow), while the stable flow (s-flow) regions are protected even under hypercholesterolemic conditions. We recently showed that d-flow alone initiates flow-induced reprogramming of endothelial cells (FIRE), including the novel concept of partial endothelial-to-immune-cell-like transition (partial EndIT), but was not validated using a genetic lineage-tracing model. Here, we tested and validated the two-hit hypothesis that d-flow is an initial instigator of partial FIRE but requires hypercholesterolemia to induce a full-blown FIRE and atherosclerotic plaque development.

Development of Anti-Inflammatory Agents Utilizing DC-SIGN Mediated IL-10 Secretion in Autoimmune and Immune-Mediated Disorders: Bridging Veterinary and Human Health.

DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) is a C-type lectin receptor expressed on dendritic cells and M2 macrophages, playing a key role in immune regulation and pathogen recognition. Its ability to mediate anti-inflammatory effects by interacting with specific ligands triggers pathways that suppress pro-inflammatory responses and promote tissue repair, making it a potential therapeutic target for inflammatory and autoimmune diseases. DC-SIGN homologs in various animal species share structural similarities and perform comparable immune functions, offering valuable insights into its broader application across species.