Osmotic stress-induced CsRCI2E endosomal trafficking modulates CsPIP2 aquaporins at the plasma membrane in Camelina sativa.

Rare Cold Inducible 2s (RCI2s) are membrane-associated proteolipids dynamically trafficking between the plasma membrane (PM) and the endomembrane system. Their expression is upregulated in response to abiotic stresses, including cold, heat, drought, and salinity, contributing to plant stress tolerance. CsRCI2E interacts with the water transport protein CsPIP2; 1, reducing its abundance at the PM under NaCl-induced stress.

integrates interspecies quorum-sensing signals to regulate virulence.

The human gut harbors enormous microbial diversity, which influences the gut's chemical environment. As the production of virulence factors affects bacterial fitness, has adapted to sense the gut chemical environment to selectively activate virulence factors at permissible intestinal niches. Here, we show that diffusible signal factors (DSFs) canonically used by gut proteobacteria for quorum-sensing communication can repress expression of essential ToxT-dependent virulence factors cholera toxin () and the toxin co-regulated pilus ().

Changes in proportions of Cesarean section before and during the COVID-19 pandemic in Japan.

Aim: After the coronavirus disease 2019 (COVID-19) pandemic, Cesarean sections for COVID-19-positive cases were performed to reduce delivery time and thus control infection. This may have increased the proportion of Cesarean sections and affected many pregnant women in Japan; though this expected trend has not yet been quantified. This study examined changes in the proportions of Cesarean sections in Japan before and during the pandemic.

Association of levonorgestrel intrauterine system and chronic kidney disease: A nationwide population-based cohort study.

Objective: Sex-, age-related discrepancies in development of chronic kidney disease (CKD) suggest that sex hormones play important roles in the development of CKD. We aimed to investigate the effect of levonorgestrel intrauterine system (LNG-IUS), one of the progestin-only agents, on the development of CKD.

Materials And Methods: This retrospective cohort study used claims data from the Korean Health Insurance Review and Assessment Service.

Association between depressive symptoms and dienogest in patients treated for endometriosis: Using the Center for Epidemiological Studies Depression (CES-D) and the State-Trait Anxiety Inventory (STAI).

Objective: This study aimed to investigate the effects of dienogest on depressive symptoms and anxiety in patients with endometriosis using the Center for Epidemiologic Studies Depression (CES-D) and State-Trait Anxiety Inventory (STAI).

Materials And Methods: This prospective observational study included patients diagnosed with endometriosis based on imaging findings or postoperative pathological tests. All participants took 2 mg dienogest (Visanne®) every day for 6 months.

Efficacy and safety of novel polyethersulfone dialyzers: a multicenter, randomized, crossover study.

Background: The continuous rise in healthcare costs associated with hemodialysis has become a growing concern in South Korea, where hemodialysis is the predominant treatment modality for end-stage kidney disease. Currently, all dialyzers are imported, underscoring the need for domestically manufactured alternatives. This study aims to evaluate the clinical efficacy and safety of a domestically produced novel polyethersulfone dialyzer.

Association between ovarian hyperstimulation syndrome and adverse obstetric and neonatal outcomes in Korea: a nationwide health insurance database study.

Purpose: To investigate the association of ovarian hyperstimulation syndrome (OHSS) and adverse maternal and neonatal outcomes.

Methods: This retrospective study used combined Korea National Health Insurance (KNHI) claims and National Health Screening Program for Infants and Children data. Women who gave birth through in vitro fertilization using fresh embryo transfer during 2017-2022 were enrolled.

The development of a preclinical swine model for endometriosis†.

Endometriosis is a benign gynecological condition in which endometrial-like tissue grows outside of the uterus, and the mechanisms of its pathogenesis are not fully understood. The anatomical and physiological parallels between pigs and humans have made pigs a good model for investigating other human diseases. Here, we report on the development of a swine model for endometriosis in which the peritoneal cavity was inoculated with autologous endometrial tissue fragments labeled with fluorescein isothiocyanate (FITC) dye-doped silica nanoparticles.

The interplay between endometriosis and obesity.

Endometriosis, characterized by uterine-like tissue growth outside the uterus, is a complex disorder with significant clinical implications. This review explores how body composition - both low body mass index (BMI) and obesity - modulates endometriosis progression through metabolic, hormonal, and immune-inflammatory pathways. Obesity-driven leptin signaling emerges as a pivotal link, promoting systemic inflammation, angiogenesis, and lesion persistence via Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathways.

Single Port Robotic Assisted Sacrocolpopexy Using Retroperitoneal Tunneling Technique.

Study Objective: To demonstrate the feasibility of performing single-port robotic assisted sacrocolpopexy.

Design: A step-by-step description of the surgical procedure using a narrated video.

Setting: Sacrocolpopexy is considered the gold standard for the apical prolapse.

Erratum to: Corrigendum: 2023 Korean Society of Menopause - Osteoporosis Guidelines Part I.

This corrects the article on p. 126 in vol. 30, PMID: 39315504.

Effects of Protocol-driven Care by Internists on Adherence to Clinical Practice Guidelines for Hip Fracture Surgery Patients: An Interrupted Time Series Study Using a Nationwide Inpatient Database.

Objective Patients with hip fractures tend to have a poor prognosis. Although guideline-compliant practices are known to improve patient outcomes, there is a lack of evidence regarding the use of intervention to improve guideline adherence in hip fracture patients. The objective of our study was to evaluate guideline adherence by internists providing care to patients with hip fractures, using a protocol developed based on various guidelines.

Impact of the guidance on fracture Liaison Services and the introduction of a new fee for secondary fracture prevention in Japan: Implementation of secondary fracture prevention during hospitalization for fragility fractures.

Unlabelled: In Japan, the publication of the Fracture Liaison Service Clinical Standard (FLS-CS) had no apparent effect on the implementation of secondary fracture prevention, but the introduction of a new management fee for secondary fracture prevention significantly promoted the implementation of secondary fracture prevention for the target disease.

Background: Secondary fracture prevention is important for managing fragility fractures. In Japan, the FLS-CS was published in 2019, alongside the introduction of a new management fee for secondary fracture prevention, launched in 2022 for patients who underwent surgery for hip fracture.

Regional variations in primary percutaneous coronary intervention for acute myocardial infarction patients: A trajectory analysis using the national claims database in Japan.

Background: Previous studies have demonstrated geographical disparities regarding the quality of care for acute myocardial infarction (AMI). The aim of this study was two-fold: first, to calculate the proportion of patients with AMI who received primary percutaneous coronary interventions (pPCIs) by secondary medical areas (SMAs), which provide general inpatient care, as a quality indicator (QI) of the process of AMI practice. Second, to identify patterns in their trajectories and to investigate the factors related to regional differences in their trajectories.

Corrigendum: 2023 Korean Society of Menopause - Osteoporosis Guidelines Part I.

This corrects the article on p. 1 in vol. 30, PMID: 38714490.

The Evaluation of Hospitalist Care for Patients with Aspiration Pneumonia Using Risk-adjusted Performance Indicators Developed from a Nationwide Inpatient Database.

Objective High-quality evidence proving the superiority of hospitalist services is lacking. We developed risk-adjusted performance indicators from a multilevel prediction model using a nationwide inpatient database to evaluate hospitalist medical care for patients with aspiration pneumonia. Methods We extracted cases diagnosed with aspiration pneumonia between 2014 and 2021 from the Diagnosis Procedure Combination (DPC) database.

Hidden Populations for Healthcare Financial Protection in the Super-Aging Society: Closing the Gap Between Policy and Practice.

Unlabelled: Despite the remarkable health achievements of Japan's universal health coverage since 1961, along with numerous social programs to ensure financial protection, a growing proportion of the older population reportedly experiences financial hardship for essential health care. The socio-behavioral and economic situation of the households in need and the effective policy interventions remain unknown. To identify the reasons behind older persons' financial hardship and the effective policy interventions, we performed a questionnaire survey of social workers in all hospitals, local government offices and social service agencies across six prefectures in Kansai region.

Impact of a financial incentive on early rehabilitation and outcomes in ICU patients: a retrospective database study in Japan.

Background: Early mobilisation of intensive care unit (ICU) patients has been recommended in clinical practice guidelines. Therefore, the Japanese universal health insurance system introduced an additional fee for early mobilisation and/or rehabilitation, which can be claimed by hospitals when starting rehabilitation of ICU patients within 48 hours after their ICU admission. However, the effect of this fee is unknown.

Intraoperative Complications and Perioperative and Surgical Outcomes of Single-Port Robotics-Assisted Sacrocolpopexy.

Introduction And Hypothesis: The objective was to assess intraoperative and postoperative complication rates, along with perioperative and surgical outcomes, following single-port robotics-assisted sacrocolpopexy.

Methods: This retrospective case series included 200 patients who underwent single-port robotics-assisted sacrocolpopexy to treat Pelvic Organ Prolapse Quantification (POPQ) stage 2-4 symptomatic prolapse between April 2020 and August 2023 by a single surgeon. Intraoperative and postoperative complications and perioperative outcomes were evaluated for all the patients, whereas surgical outcomes for 74 patients were assessed at 1-year follow-up.

Changes in anti-Müllerian hormone values for ovarian reserve after minimally invasive benign ovarian cystectomy: comparison of the Da Vinci robotic systems (Xi and SP) and the laparoscopic system.

To investigate the impact on the ovarian reserve after minimally invasive ovarian cystectomy using two platforms, the Da Vinci robotic system (Xi and SP) and the laparoscopic system. Patients underwent laparoscopic or Da Vinci robotic (Xi or SP) ovarian cystectomy for benign ovarian cysts between January 1, 2018, and December 31, 2022 at Guro Hospital, Korea University Medical center. We measured the change of AMH values (%) = [(postAMH - preAMH)] × 100/preAMH.

Automatic Mechanical Ventilation vs Manual Bag Ventilation During CPR: A Pilot Randomized Controlled Trial.

Background: There is insufficient evidence supporting the theory that mechanical ventilation can replace the manual ventilation method during CPR.

Research Question: Is using automatic mechanical ventilation (MV) feasible and comparable to the manual ventilation method during CPR?

Study Design And Methods: This pilot randomized controlled trial compared MV and manual bag ventilation (BV) during CPR after out-of-hospital cardiac arrest (OHCA). Patients with medical OHCA arriving at the ED were randomly assigned to two groups: an MV group using a mechanical ventilator and a BV group using a bag valve mask.

Presenteeism and social interaction in the "new normal" in Japan: a longitudinal questionnaire study.

Background: Although social interaction and social support during the "new normal" due to coronavirus disease 2019 (COVID-19) may be related to presenteeism, the effect between these factors has not been clear for Japanese workers. The aim of this study was to describe the presenteeism of Japanese workers with reference to social interaction and social support following the lifestyle changes due to COVID-19 and to assess whether social interaction and social support affected their presenteeism.

Methods: The data were obtained from internet panel surveys from October 2020.