Exploring the inhibitory effects of extract and sinigrin on lipid accumulation in BPA-Induced 3T3-L1 cells via the glucocorticoid receptor and peroxisome proliferator-activated receptor-γ pathways.

Obesogens, such as bisphenol A (BPA), are emerging models for obesity research, yet their mechanisms remain less explored. While BPA has been extensively studied for its estrogen receptor interactions, its effects on the glucocorticoid receptor (GR) remain unclear. This study explored the role of the GR in BPA-induced lipid accumulation using the GR antagonist mifepristone (10 μM) and the PPAR-γ antagonist GW9662 (15 μM) in 3T3-L1 preadipocytes.

Research status of anti-obesogenic functional foods: mechanism of endocrine-disrupting chemicals and glucocorticoid receptor pathway.

Obesity due to excessive fat accumulation, affects health and quality of life and increases the risk of diseases such as type 2 diabetes and cardiovascular conditions. Traditional causes, such as calorie excess and sedentary behavior, do not fully explain the obesity epidemic, leading to the hypothesis that endocrine-disrupting chemicals or obesogens contribute to obesity. The obesogenic mechanisms of representative obesogenic substances, such as bisphenols, have been discussed, mainly focusing on their interactions with estrogen receptors.

Beneficial effects of sauce meeting the functional labeling system claim on dexamethasone-induced C2C12 myotube and hindlimb immobilization-induced C57BL/6J mice.

Unlabelled: This study investigated the potential of sauce meeting the functional labeling system (TSF) with resistant maltodextrin on muscle atrophy using dexamethasone-induced C2C12 myotubes and hindlimb immobilization (HI)-induced C57BL/6J mice. TSF significantly improved cell viability, myotube diameter, and fusion index in C2C12 myotubes. Furthermore, TSF effectively mitigated HI-induced muscle atrophy in mice, enhanced grip strength, and increased muscle mass.

Fermented red ginseng extract improves sarcopenia-related muscle atrophy in old mice through regulation of muscle protein metabolism.

This study investigated the potential ameliorative effects of fermented red ginseng (FRG) extract on sarcopenia-related muscle atrophy in old mice and elucidated the underlying mechanisms. Mice, aged five and twenty months, were divided into seven groups: young and old controls, and old mice treated with extract (200 mg/kg/day), mixed ginsenosides (15 mg/kg/day), and FRG extract (50-200 mg/kg/day). Body weight and grip strength were assessed weekly.

Anti-obesogenic effect of standardized extract on bisphenol A-induced 3T3-L1 preadipocytes and C57BL/6J obese mice.

Bisphenol A (BPA) is a representative obesogen that induces adipocyte differentiation and lipid accumulation by mimicking the action of hormones. is a plant belonging to the mustard family, and has antioxidant, anti-inflammatory, and anti-obesity effects. However, its efficacy against obesogen-induced obesity requires further investigation.

Ameliorative Effects of Fermented Red Ginseng Extract on Muscle Atrophy in Dexamethasone-Induced C2C12 Cell And Hind Limb-Immobilized C57BL/6J Mice.

Fermented red ginseng (FRG) enhances the bioactivity and bioavailability of ginsenosides, which possess various immunomodulatory, antiaging, anti-obesity, and antidiabetic properties. However, the effects of FRG extract on muscle atrophy and the underlying molecular mechanisms remain unclear. This study aimed to elucidate the effects of FRG extract on muscle atrophy using both and models.

The Mechanism of the Anti-Obesity Effects of a Standardized Extract in 3T3-L1 Preadipocytes and High-Fat Diet-Induced Obese C57BL/6J Mice.

Obesity is a global health concern. Recent research has suggested that the development of anti-obesity ingredients and functional foods should focus on natural products without side effects. We examined the effectiveness and underlying mechanisms of extract (BJE) in combating obesity via experiments conducted in both in vitro and in vivo obesity models.

Plant sources, extraction techniques, analytical methods, bioactivity, and bioavailability of sulforaphane: a review.

Sulforaphane (SFN) is an isothiocyanate commonly found in cruciferous vegetables. It is formed via the enzymatic hydrolysis of glucoraphanin by myrosinase. SFN exerts various biological effects, including anti-cancer, anti-oxidation, anti-obesity, and anti-inflammatory effects, and is widely used in functional foods and clinical medicine.