A Scoping Review of Health-Related Citizen Science Projects Involving Indigenous Peoples in Australia and Internationally.

Issue Addressed: Citizen science, an approach to health promotion that involves public participation and collaboration, has been posited as a promising approach to reach diverse or marginalised populations. This scoping review aims to explore the involvement of Aboriginal and Torres Strait Islanders and other First Nations and Indigenous peoples internationally in citizen science in health-related studies. While current health promotion in Indigenous communities is already strongly embedded in participatory approaches, we sought to examine whether citizen science methodologies have been used in health promotion and see what it could add.

Recurrence After Esophagectomy for Esophageal Cancer: High-Volume Center Surveillance Imaging Outcomes.

Background: Despite treatment advancements, esophageal cancer survival remains poor due to high recurrence rates. Early detection of recurrence may allow for timely treatment and improved outcomes. This study evaluated recurrence patterns and detection methods using different imaging surveillance strategies after esophagectomy.

A Plant-Based Dietary Supplement Exhibits Significant Effects on Markers of Oxidative Stress, Inflammation, and Immune Response in Subjects Recovering from Respiratory Viral Infection: A Randomized, Double-Blind Clinical Study Using Vitamin C as a Positive Control.

Respiratory viruses continue to present serious health challenges to human wellness. Growing evidence suggests that the more severe and damaging effects and symptoms of influenza, rhinovirus (RV), respiratory syncytial virus (RSV), and COVID-19 may primarily result from their common ability to disorganize the body's healthy immune response. The simultaneous over-stimulation of several reactive oxygen species (ROS) pathways and concurrent suppression of bioavailable Nitic Oxide (NO) contribute to an immune disbalance that can lead to cellular oxidative distress and an excessive inflammatory response.

Integrating Australian Native Foods for a More Sustainable Food System: A Qualitative Co-Design Study with Aboriginal Communities.

(1) Background: Integrating native foods into food systems has shown promising benefits for health, the environment, and the revitalisation of Aboriginal culture. This study aims to explore the benefits, facilitators, and barriers of integrating Australian native foods into the current food system and how traditional knowledge around these foods can be revitalised in a culturally safe way. (2) Methods: This qualitative co-design study involved the following four phases: (I) Relationship building with the communities and cultural training for the research team; (II) Establishment of the Aboriginal Reference Group (ARG) for community involvement and governance; (III) Data collection through interviews and focus groups with participants from two urban Aboriginal communities in Sydney and experts in native foods; and (IV) Collaborative data analysis using both deductive and inductive thematic analysis.

Spin wave Brillouin measurements in FeCo with a virtually imaged phased array spectrometer.

We demonstrate for what we believe to be the first time the efficient acquisition of spin wave Brillouin spectra with a virtually imaged phase array-based spectrometer and an etalon-based notch filter. Thermally excited magnons in a 5 nm epitaxially grown single-crystalline FeCo film are detectable within 100 ms and a signal-to-noise ratio greater than 100 is achieved in 10 seconds with a spectral resolution of 0.45 GHz and a pump power of 23 mW.

Global impoverishment of natural vegetation revealed by dark diversity.

Anthropogenic biodiversity decline threatens the functioning of ecosystems and the many benefits they provide to humanity. As well as causing species losses in directly affected locations, human influence might also reduce biodiversity in relatively unmodified vegetation if far-reaching anthropogenic effects trigger local extinctions and hinder recolonization. Here we show that local plant diversity is globally negatively related to the level of anthropogenic activity in the surrounding region.

Phase I, First-in-Human Study of FOR46 (FG-3246), an Immune-Modulating Antibody-Drug Conjugate Targeting CD46, in Patients With Metastatic Castration-Resistant Prostate Cancer.

Purpose: FOR46, a fully human antibody conjugated to monomethyl auristatin E, targets a tumor-selective epitope of CD46, which is overexpressed in metastatic castration-resistant prostate cancer (mCRPC). FOR46 demonstrates potent nonclinical activity in enzalutamide-resistant CRPC models.

Patients And Methods: This was a phase I, first-in-human, dose escalation/expansion study in patients with progressive mCRPC after treatment with ≥one androgen signaling inhibitors (ClinicalTrials.

Post-esophagectomy hiatal hernia following minimally invasive esophagectomy in esophageal cancer patients.

Introduction: Minimally invasive esophagectomy (MIE) has emerged as the preferred surgical method for esophageal cancer resulting from lower morbidity rates for MIE compared to open surgery. However, post-esophagectomy hiatal hernia (PEHH), also known as paraconduit hernia, once rare, is now increasingly observed as a late complication. This study aims to ascertain the prevalence, predictive factors, and surgical management of PEHH following MIE in esophageal cancer patients.

Older adults know when they have been left out but they respond rationally.

Previous research reveals that older adults have relatively intact well-being when excluded by others as compared to young adults. This observation can be attributed to two plausible explanations: Either older adults are unaware of their exclusion, thereby shielding their well-being from its impact, or they recognize the exclusion but respond to it rationally. We carried out two studies to compare young and older adults' awareness of and response to exclusion, and explored its potential mechanisms by assessing the explanatory roles of loneliness, general cognition, and rejection sensitivity.

Parasympathetic Regulation and Maternal Parenting as Longitudinal Predictors of Preschooler Inhibitory Control.

Measures of parasympathetic regulation, such as respiratory sinus arrhythmia (RSA), predict executive function outcomes, including inhibitory control, across childhood. Respiratory sinus arrhythmia augmentation tends to be associated with more maladaptive outcomes compared to RSA suppression, but the literature regarding RSA profiles and inhibitory control development across infancy and early childhood is contradictory. The goal of our current study was to examine the longitudinal and interactive effects of infant RSA during a frustrating task with negative maternal characteristics on inhibitory control during early childhood.

Digital Meditation to Target Employee Stress: A Randomized Clinical Trial.

Importance: Mindfulness meditation may improve well-being among employees; however, effects of digital meditation programs are poorly understood.

Objective: To evaluate the effects of digital meditation vs a waiting list condition on general and work-specific stress and whether greater engagement in the intervention moderates these effects.

Design, Setting, And Participants: This randomized clinical trial included a volunteer sample of adults (aged ≥18 years) employed at a large academic medical center who reported mild to moderate stress, had regular access to a web-connected device, and were fluent in English.

Interventions and Programs Using Native Foods to Promote Health: A Scoping Review.

(1) Background: Native foods are essential for promoting health, sustainability, and the resilience of Indigenous communities. They contribute to biodiversity, are adapted to local ecosystems, and support cultural identity. This study aims to identify and describe strategies and health outcomes from programs and interventions using native foods to promote health or address food insecurity.

Minimally Invasive Transhiatal Esophagectomy Using Antegrade Inversion Technique in Esophageal Cancer: 10-Year Experience from a Tertiary Care Center.

Esophageal cancer surgery aims for curative intent but carries high complication rates. Transthoracic esophagectomy is the dominant approach, however, transhiatal esophagectomy (THE) offers selective advantages in certain clinical scenarios. Minimally invasive THE (MI-THE) is an evolving technique with limited data.

Whole Coffee Cherry Extract Improves Working Memory and Response Inhibition: Acute and Longitudinal Results from a Remote, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Earlier laboratory-based evidence has suggested that polyphenol-rich, decaffeinated whole coffee cherry extract (CCE) supports improvements in acute and long-term cognitive performance. To better understand CCE's potential to promote cognitive processing, we conducted a first-of-its-kind remote clinical trial. Participants were randomized into one of two intervention arms: placebo or 200 mg CCE.

Food Choices, Sustainability and Australian Native Foods: Perceptions among University Students.

(1) Background: Urgent changes in our food choices are needed for more sustainable, resilient and equitable food systems. Australian native plant-based foods have both environmental and health benefits. Including these foods in our diet may reduce both the risk of chronic diseases and the impact of climate change.

Nutritional supplementation, tooth crown size, and trait expression in individuals from Tezonteopan, Mexico.

Understanding how epigenetic factors impact dental phenotypes can help refine the use of teeth for elucidating biological relationships among human populations. We explored relationships among crown size, principal cusp spacing, and accessory cusp expression in maxillary dental casts of nutritionally supplemented (n = 34) and non-supplemented (n = 39) individuals from Tezonteopan, Mexico. We hypothesized that the non-supplemented group would exhibit smaller molar crowns and reduced intercusp spacing.

Single centre observational study evaluating the impact of introducing High Flow Nasal Cannula outside of Paediatric Critical Care Unit.

Aim: To evaluate the impact of High Flow Nasal Cannula (HFNC) introduction outside of Paediatric Critical Care Units (PCCU), on PCCU admissions and intubation rates. Secondarily, to identify escalation predictors.

Methods: Retrospective observational study with matched PCCU admissions and intubation rates, 2-years before (Group 1) and 2-years after (Group 2) HFNC introduction outside of PCCU.

ST-2560, a selective inhibitor of the Na1.7 sodium channel, affects nocifensive and cardiovascular reflexes in non-human primates.

Background And Purpose: The voltage-gated sodium channel isoform Na1.7 is a high-interest target for the development of non-opioid analgesics due to its preferential expression in pain-sensing neurons. Na1.

Affect variability and cortisol in context: The moderating roles of mean affect and stress.

Positive and negative affect have been shown to have implications for hormones like cortisol but how moment to moment changes in affect (i.e., affect variability) influence cortisol secretion is less well understood.

Co-Designing Research for Sustainable Food Systems and Diets with Aboriginal Communities: A Study Protocol.

(1) Background: Food choices and systems have contributed to various health and environmental issues, resulting in the global syndemic (obesity, undernutrition and climate change). Studies show that revitalizing Indigenous food systems and including native plant-based foods in our diet may be important for promoting health, reducing diet-linked chronic diseases and mitigating environmental changes. However, it is still a challenge to 'Indigenize' research by including Aboriginal people in all project phases to achieve culturally appropriate collaboration.

Understanding Post-Esophagectomy Complications and Their Management: The Early Complications.

Esophagectomy is a technically complex operation performed for both benign and malignant esophageal disease. Medical and surgical advancements have led to improved outcomes in esophagectomy patients over the past several decades; however, surgeons must remain vigilant as complications happen often and can be severe. Post-esophagectomy complications can be grouped into early and late categories.