Dynamic Tumor in Situ Fluid Circulating Tumor DNA Postsurgery Effectively Predicts Recurrence and Clinical Benefits for Glioblastomas.

Background And Objectives: Glioblastoma (GBM) recurrence after surgery remains a significant clinical challenge because of limited early detection methods and effective molecular markers. This study investigates the potential of dynamic tumor in situ fluid circulating tumor DNA (TISF-ctDNA) as a tool for monitoring molecular residual disease and evaluating treatment efficacy in postsurgical patients with GBM.

Methods: In this prospective cohort study, 75 resectable glioma patients were enrolled between October 2019 to June 2023.

Dynamic Monitoring of Circulating Tumor DNA to Predict the Risk of Non In Situ Recurrence of Postoperative Glioma: A Prospective Cohort Study.

Background: Glioma recurrence can be divided into in situ recurrence and non-in situ recurrence, and the mutation evolution of gliomas with different recurrence patterns is still unknown. We used sequential sequencing of circulating tumor DNA (ctDNA) to compare the somatic mutation profile and clonal evolution of gliomas with different recurrence patterns. To investigate the value of ctDNA in predicting early postoperative tumor recurrence and guiding prognosis stratification in patients with glioma.

Enhanced tetracycline degradation using carbonized PEI-grafted lignin microspheres supported Fe-loading catalyst across a wide pH range in Fenton-like reactions.

Traditional homogeneous Fenton systems face limitations, including a narrow pH range, potential secondary pollution, and poor repeatability. In this study, these bottlenecks in tetracycline wastewater treatment were addressed with using carbonized porous polyethyleneimine-grafted lignin microspheres (PLMs) supported Fe-loading catalysts (PLMs/Fe-C). An optimized PLMs/Fe-C catalyst under specific conditions (carbonization temperature: 350 °C, PLMs: Fe = 1:1, and alkali lignin: PEI = 1:4) was developed, which proved to be an efficient Fenton-like catalyst for tetracycline (TC) degradation.

Dynamics of tumor in situ fluid circulating tumor DNA in recurrent glioblastomas forecasts treatment efficacy of immune checkpoint blockade coupled with low-dose bevacizumab.

Purpose: Immune checkpoint blockade (ICB) therapies have shown efficacy in various tumors, but long-term responses in glioblastoma are less than 10%. Quantifying tumor in situ fluid circulating tumor DNA (TISF-ctDNA) and therapeutic dynamics may enable real-time GBM disease burden evaluation. This study explores the potential of tumor in situ fluid circulating tumor DNA (TISF-ctDNA) dynamics in predicting treatment efficacy.

Catalytic hydrothermal liquefaction of alkali lignin for monophenols production over homologous biochar-supported copper catalysts in water.

Constructing an advanced catalytic system for the purposeful liquefaction of lignin into chemicals has presented a significant prospect for sustainable development. In this work, the catalytic process of mesoporous homologous biochar (HBC) derived from alkali lignin supported copper catalysts (Cu/HBC) was reported for catalytic liquefaction of alkali lignin to monophenols. The characterization results revealed HBC promoted the formation of metal-support strong interaction and the generation of oxygen vacancies, enhancing the acid sites of Cu/HBC.

Lignin microparticles-reinforced cellulose filter paper for simultaneous removal of emulsified oils and dyes.

The presence of multiple pollutants in wastewater, often with complex interactions, poses a significant challenge for conventional membranes to effectively remove multiple pollutants simultaneously. Herein, a lignin microparticles-reinforced cellulose filter paper (FP@AL-LS-DA) was fabricated via an aldol condensation between lignin and cellulose filter paper and cross-linking with dopamine hydrochloride (DA), which showed desired rejection of oil-in-water emulsions and dyes. Characterizations revealed that the addition of lignin and DA effectively narrowed the pore size (from 4.

Synchronous catalytic depolymerization of alkaline lignin to monophenols with in situ-converted hierarchical zeolite for bio-polyurethane production.

Catalytic depolymerization of lignin to high-value chemicals is crucial to the comprehensive achievement of sustainable and economic concerns. Herein, we propose a green, practical, and economic strategy for the synchronous catalytic depolymerization of lignin based on in situ conversion of geopolymer precursor to hierarchical zeolite, using water as a mild solvent and without external H, additives, co-catalysts or co-solvents. The in situ-converted hierarchical analcime (ANA) zeolite outperformed previously reported representative catalysts, such as PTA/MCM-41 and CuAlMgO in lignin depolymerization with a high monophenol yield (95.

A Low-Cost Biomimetic Heterostructured Multilayer Membrane with Geopolymer Microparticles for Broad-Spectrum Water Purification.

Membranes have received wide interest in water purification. However, the development of a low-cost and eco-friendly membrane with the desired structure for broad-spectrum water purification still remains a great challenge. Inspired by the hierarchical structure and functions of wood, a heterostructured multilayer membrane fabricated through a facile and "green" layer-by-layer self-assembly method was reported in this study.

Facile fabrication of a low-cost and environmentally friendly inorganic-organic composite membrane for aquatic dye removal.

This study reports a new inorganic-organic composite membrane fabricated by an electrostatic self-assembling method. The low-cost and eco-friendly porous geopolymer (PG) was chosen as a support, on which chitosan (CS), a "green" biomaterial, was used to form an active layer. With optimum dosage of CS (2.