Loss of Angulin-1/LSR promotes vasculogenic mimicry and epithelial-mesenchymal transition in breast cancer.

Vasculogenic mimicry (VM) is a process by which tumor cells form vessel-like network to secure oxygen and nutrients essential for tumor growth. Intercellular junctions, including tight junctions, may play a critical role in this process, important for VM. Here, we investigated the role of angulin-1/LSR (Ang-1), a key component of tricellular tight junctions, in VM regulation.

A Case of Calcified Nodule in the Saphenous Vein Graft Successfully Treated by Guide Extension Catheter-Supported Orbital Atherectomy System.

The use of debulking devices in saphenous vein graft (SVG) interventions is generally contraindicated due to the risk of vascular injury, making the treatment of heavily calcified lesions challenging. We report the case of a 73-year-old man who developed unstable angina 26 years after coronary artery bypass grafting. Urgent coronary angiography revealed severe calcification and critical stenosis at the SVG-to-left anterior descending artery (LAD) anastomosis.

The First-in-Man Technique of Drug Eluting and Perfusion Therapy for Left Main Coronary Artery Disease.

Background: Treating ostial left circumflex artery (LCx) lesions in percutaneous coronary intervention (PCI) for left main disease (LMD) remains a challenge. Despite recent recommendations for the use of drug-coated balloon (DCB) in this lesion, there are concerns about crossover-stenting from the left main trunk (LMT) to the left anterior descending artery (LAD). Specifically, isolated DCB treatment for the ostial LCx lesion may induce carina shift, while conventional kissing balloon technique (C-KBT) with a standard balloon and a DCB may prolong LMT occlusion, leading to hemodynamic instability.

Comprehensive Self-Management of Heart Failure.

In response to the heart failure (HF) pandemic, it is important to introduce appropriate pharmacological and non-pharmacological treatments for HF patients. In addition, self-management of HF, including the continuation of appropriate pharmacological treatment, is also important. There have been many reports on self-management of HF.

Simultaneous Subacute Stent Thrombosis of 2 Coronary Arteries Complicating Immune Thrombocytopenia Treated by Eltrombopag.

Simultaneous subacute occlusion of the latest drug-eluting stents in 2 coronary arteries was documented in an immune thrombocytopenia patient receiving eltrombopag while undergoing potent dual antiplatelet therapy. Careful consideration is needed for the interruption of eltrombopag and the timing of staged percutaneous coronary intervention after the initial coronary event.

An ensemble learning model for detection of pulmonary hypertension using electrocardiogram, chest X-ray, and brain natriuretic peptide.

Aims: Delayed diagnosis of pulmonary hypertension (PH) is a known cause of poor patient prognosis. We aimed to develop an artificial intelligence (AI) model, using ensemble learning method to detect PH using electrocardiography (ECG), chest X-ray (CXR), and brain natriuretic peptide (BNP), facilitating accurate detection and prompting further examinations.

Methods And Results: We developed a convolutional neural network model using ECG data to predict PH, labelled by ECG from seven institutions.

Autoregulation of the Coronary Microcirculation in the Presence or Absence of Large Pericardial Effusion.

Although the impact of the presence of large circumferential pericardial effusion (LCPE) on the intracoronary pressure assessment of coronary artery disease (CAD) has been reported, the changes in comprehensive coronary physiology including coronary microcirculatory system according to the presence or absence of LCPE remain unclear. This paper depicts the serial changes in comprehensive coronary physiological assessment immediately after pericardial drainage in a patient with LCPE and CAD. It is important to recognize that the presence of LCPE may influence coronary circulation, requiring careful assessment of CAD.

Impact of screw reinsertion on osteosynthesis stability in Schatzker IV tibial plateau fractures: a biomechanical study.

Introduction: This biomechanical study evaluated the effect of screw reinsertion with a locking plate on fixation strength and the stability of osteosynthesis in medial tibial plateau fractures using porcine bone.

Materials And Methods: Thirty porcine tibiae were divided into three groups: group A (underwent biomechanical testing after medial tibial fixation with a large fragment T-shaped locking plate), group B (underwent plate fixation, followed by the removal of all screws and plates and refixation with the same screws and plates using the same holes before biomechanical testing), and group C (underwent biomechanical testing once after plate fixation, followed by the removal of all screws and plates, refixation with the same screws and plates using the same holes, and then biomechanical testing). The translation pattern of the constructs in each group was examined using cyclic loading tests.

Polymer-free sirolimus- and probucol-eluting stents versus durable polymer-based everolimus-eluting stents for percutaneous coronary revascularization: A prospective multicenter randomized clinical trial.

Background: Owing to the advent of new generation drug-eluting stents, percutaneous coronary intervention (PCI) outcomes are improving. However, the polymers, which have been the most common type of coatings used in drug-eluting stents, have some issues. The study aim was to evaluate the clinical outcomes of patients undergoing PCI with polymer-free sirolimus- and probucol-eluting stents (NP023).

Deep Learning-Based Identification of Echocardiographic Abnormalities From Electrocardiograms.

Background: Heart failure should be diagnosed as early as possible. Although deep learning models can predict one or more echocardiographic findings from electrocardiograms (ECGs), such analyses are not comprehensive.

Objectives: This study aimed to develop a deep learning model for comprehensive prediction of echocardiographic findings from ECGs.

Case report of belt electrode-skeletal muscle electrical stimulation for acute heart failure with severe obesity: a novel therapeutic option for acute phase rehabilitation.

Background: Belt electrode skeletal muscle electrical stimulation (B-SES) is an emerging therapy anticipated to yield more favorable outcomes than conventional neuromuscular electrical stimulation (NMES), owing to its larger stimulation area. However, information on its efficacy and safety in patients with heart failure remains limited.

Case Presentation: A 43-year-old man with a body mass index of 41 kg/m was admitted to our hospital for acute heart failure due to dilated cardiomyopathy.

Absence of Anaphylactic Reactions to Injection of Hemoglobin Vesicles (Artificial Red Cells) to Rodents.

The safety and efficacy of hemoglobin vesicles (HbVs) as artificial oxygen carriers encapsulating a purified and concentrated Hb solution in liposomes have been studied extensively. The HbV surface, modified with PEG by incorporating a PEG-conjugated phospholipid, is beneficial for storage and biocompatibility. However, it might be possible that interaction of PEG and the pre-existing anti-PEG antibody in the bloodstream causes acute adverse reaction.

Epidemiology of distal radius fracture: a regional population-based study in Japan.

Background: Distal radius fracture (DRF) is very common worldwide. In particular, aging countries have numerous patients with DRF, resulting in an urgent need for active preventive measures. As few epidemiological studies have investigated DRF in Japan, we aimed to identify the epidemiological characteristics of patients of all ages with DRF in Japan.