Combined oxybenzone and UVB exposure induces metabolic and neural dysregulation in Mugilogobius chulae embryos and larvae.

The widespread use of sunscreens has contaminated aquatic environments with UV filters like oxybenzone (BP-3), which act as endocrine disruptors in aquatic organisms and exhibit enhanced toxicity under UV radiation. This study employed a multi-omics approach integrating responses from genes to whole organisms to investigate UVB-potentiated toxicity of BP-3 in embryos of the marine fish Mugilogobius chulae. Results demonstrated that UVB significantly amplified BP-3 toxicity, reducing LC from 5674 μg L⁻¹ to 3653 μg L⁻¹ and impairing key developmental endpoints: spontaneous movement, heart rate, and body length.

Embryonic developmental toxicity to estuarine fish: Single and co-exposure to EHMC and its phototransformation products in Mugilogobius chulae.

The ecological risks posed by organic ultraviolet filters (OUVFs) and their phototransformation products to estuarine ecosystems remain inadequately characterized. This study investigated the developmental toxicity in the early-life stages of the estuarine fish Mugilogobius chulae when exposed individually and jointly to 2-Ethylhexyl 4-methoxycinnamate (EHMC) and its phototransformation products (2-ethylhexanol (2-EH) and 4-methylbenzaldehyde (4-MBA)). The 120 h no-observed-effect concentration (NOEC) for embryonic malformations was >34435 nM (10000 μg/L) for EHMC, 61429 nM (8000 μg/L) for 2-EH, and 10283 nM (1400 μg/L) for 4-MBA.

Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.

Atorvastatin (ATV), a commonly prescribed lipid-lowering drug, has been widely detected in various aquatic environments due to its large use and low degradation rate. Since the target gene inhibited by ATV is highly conserved in organisms, many studies have shown that ATV can interfere with lipid metabolism in aquatic non-target organisms. However, studies on mitochondria, energy metabolism, and developmental toxicity of ATV on non-target organisms are limited.

A tiered toxicity testing strategy for assessing early life stage toxicity in estuarine fish (Mugilogobius chulae): A case study on tris (1-chloro-2-propyl) phosphate ester.

The estuarine ecological environment faces significant threats from contaminants of emerging concern (CECs); yet, the risk posed by CECs to resident organisms remains poorly understood. Here, we employed tiered toxicity testing to investigate the adverse effects and potential mechanisms of tris (1-chloro-2-propyl) phosphate (TCPP) on the early life stages of an estuarine fish, Mugilogobius chulae. TCPP affected the development of M.

Aspirin exposure coupled with hypoxia interferes energy metabolism, antioxidant and autophagic processes and causes liver injury in estuarine goby Mugilogobius chulae.

Toxicity assessments of pollutants often overlook the impact of environmental factors like hypoxia, which can alter chemical toxicity with unexpected consequences. In this study, Mugilogobius chulae, an estuarine fish, was used to investigate the effects of hypoxia (H), aspirin (ASA), and their combination (H_ASA) exposure over 24, 72, and 168 h. We employed RNA-seq analysis, expression of key gene expression profiling, enzymatic activity assays, and histopathological and ultrastructural examinations of liver tissue to explore the effects and mechanisms of ASA-coupled hypoxia exposure in fish.

Atorvastatin causes developmental and behavioral toxicity in yellowstripe goby (Mugilogobius chulae) embryos/larvae via disrupting lipid metabolism and autophagy processes.

Atorvastatin (ATV) is one of the most commonly prescribed lipid-lowering drugs detected frequently in the environment due to its high use and low degradation rate. However, the toxic effects of residual ATV in the aquatic environment on non-target organisms and its toxic mechanisms are still largely unknown. In the present study, embryos of a native estuarine benthic fish, Mugilogobius chulae, were employed to investigate the developmental and behavioral toxic effects of ATV including environmentally relevant concentrations.

Response of lipid metabolism, energy supply, and cell fate in yellowstripe goby (Mugilogobius chulae) exposed to environmentally relevant concentrations atorvastatin.

The usage of typical pharmaceuticals and personal care products (PPCPs) such as cardiovascular and lipid-modulating drugs in clinical care accounts for the largest share of pharmaceutical consumption in most countries. Atorvastatin (ATV), one of the most commonly used lipid-lowering drugs, is frequently detected with lower concentrations in aquatic environments owing to its wide application, low removal, and degradation rates. However, the adverse effects of ATV on non-target aquatic organisms, especially the molecular mechanisms behind the toxic effects, still remain unclear.

Hypoxia aggravates the burden of yellowstripe goby (Mugilogobius chulae) under atorvastatin exposure.

In the present study, an estuarine benthic fish, Mugilogobius chulae (M. chulae), was exposed to hypoxia, atorvastatin (ATV), a highly used and widely detected lipid-lowering drug in aquatic environment, and the combination of hypoxia and ATV for 7 days, respectively, so as to address and compare the effects of the combination of hypoxia and ATV exposure on M. chulae.

Anomalous reflection from hybrid metamaterial slab.

We report for the first time that an ultra-thin hybrid metamaterial slab can reflect an incident plane wave in -1st diffraction order, giving rise to anomalous reflection in a "negative" way. The functionality is derived from the hybridized surface resonant states of the slab. The retro-directive reflection is demonstrated numerically for a Gaussian beam at oblique incidence and verified experimentally at microwave frequencies.