Multimodal PAI/OCT Imaging System for Precision Diagnosis and Therapy in Atopic Dermatitis: A Pilot Study.

Atopic dermatitis (AD), a chronic inflammatory skin disorder, faces diagnostic limitations due to subjective clinical assessments. This study introduces an integrated photoacoustic imaging (PAI)/optical coherence tomography (OCT) system for noninvasive, quantitative evaluation of MC903-induced AD-like dermatitis in mice and Crisaborole efficacy. Multimodal imaging demonstrated Crisaborole's suppression of pathological angiogenesis (50.

A novel chlorine derivative ShengTaiBuFen mediated photodynamic therapy on a mouse wound model infected with methicillin-resistant Staphylococcus aureus.

Methicillin-resistant Staphylococcus aureus (MRSA) is the most common and difficult-to-treat pathogen in chronic wounds. In this study, a novel derivative of chlorin, ShengTaiBuFen (STBF), was used as a photosensitiser to investigate the effect of STBF mediated photodynamic therapy (STBF-PDT) on MRSA-infected ulcers. Appropriate incubation time and concentration parameters were initially explored to evaluate the anti-MRSA performance of STBF-PDT in vitro.

Successful application of ALA-PDT in rare cutaneous infection of Mycobacterium parascrofulaceum.

Skin infections caused by Mycobacterium parascrofulaceum (MP) are extremely rare in clinical practice. In view of its potential hazard of spreading to systemic infection, correct diagnosis and effective treatment are extremely important. Due to the highly similar appearance of lymphangitic sporotrichosis (LS) and swimming pool granuloma (SPG) caused by Mycobacterium marinum (MM), MP infection is easily misdiagnosed as the above two skin diseases.

A novel chlorin e6 derivative-mediated photodynamic therapy STBF-PDT reverses photoaging via the TGF-β pathway.

Objective: Photoaging is characterized by wrinkles in the skin and the deterioration of the skin barrier function, mainly caused by long-term exposure to ultraviolet (UV) radiation. Photodynamic therapy (PDT) has been shown to treat photoaging. The novel photosensitizer ShengTaiBuFen(STBF) is a derived substance of Chlorin e6(Ce6) that can exert photodynamic effects directly.

Ruyi Jinhuang Powder accelerated diabetic ulcer wound healing by regulating Wnt/β-catenin signaling pathway of fibroblasts In Vivo and In Vitro.

Ethnopharmacological Relevance: Diabetic ulcer is a common complication of diabetes. Therapies of diabetic ulcer are still challenging due to the complicated aetiology. Ruyi Jinhuang Powder (RJP) is gradually adopted to treat diabetic ulcer and has a significant therapeutic effect.