[Case report of dentinogenesis imperfecta and review of literature].

Dentinogenesis imperfecta is a dentin development disorder inherited in an autosomal dominant manner. It is rarely seen in clinical with a low incidence rate. We reported a case of dentinogenesis imperfecta referred to the Department of Pediatric Dentistry, Hospital of Stomatology, Lanzhou University.

The effects of indole-2,3-dione on radiosensitivity of U251 cells and zebrafish embryos.

Radiotherapy is an effective treatment for gliomas, which are among the most malignant tumors in the central nervous system (CNS). A significant challenge in glioma radiotherapy is improving tumor control while minimizing damage to normal nervous tissue. In this study, we investigated the dual role of indole-2,3-dione (Isatin, ISA), a compound with diverse biological and pharmacological activities, including anticancer, antioxidant, and anti-inflammatory properties, in modulating radiosensitivity.

Establishing a deeper understanding of the osteogenic differentiation of monolayer cultured human pluripotent stem cells using novel and detailed analyses.

Background: Derivation of osteoblast-like cells from human pluripotent stem cells (hPSCs) is a popular topic in bone tissue engineering. Although many improvements have been achieved, the low induction efficiency because of spontaneous differentiation hampers their applications. To solve this problem, a detailed understanding of the osteogenic differentiation process of hPSCs is urgently needed.

Toxic effects of Fe ion radiation on the zebrafish (Danio rerio) embryonic development.

All living organisms and ecosystems are permanently exposed to ionizing radiation. Of all the types of ionizing radiation, heavy ions such as Fe have the potential to cause the most severe biological effects. We therefore examined the effects and potential mechanisms of iron ion irradiation on the induction of developmental toxicity and apoptosis in zebrafish embryos.

Effects of Ru(CO)3Cl-glycinate on the developmental toxicities induced by X-ray and carbon-ion irradiation in zebrafish embryos.

The inhibitory effects of carbon monoxide (CO), generated by Ru(CO)Cl-glycinate [CO-releasing molecule (CORM-3)], on developmental toxicity in zebrafish embryos induced by ionizing radiation with different linear energy transfer (LET) were studied. Zebrafish embryos at 5h post-fertilization were irradiated with X-ray (low-LET) and carbon-ion (high-LET) with or without pretreatment of CORM-3 1h before irradiation. CORM-3 pre-treatment showed a significant inhibitory effect on X-ray irradiation-induced developmental toxicity, but had little effect on carbon-ion irradiation-induced developmental toxicity.

Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae.

The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization.

Toxicity of Graphene Quantum Dots in Zebrafish Embryo.

Objective: To evaluate the bio-safety of graphene quantum dots (GQDs), we studied its effects on the embryonic development of zebrafish.

Methods: In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 μg/mL for 4-96 h post-fertilization (hpf).