Potential mechanism of 25R-inokosterone in the treatment of osteoporosis: Based on bioinformatics and molecular dynamics model.

25R-inokosterone, a sterone derived from Achyranthes bidentata Bl., has potential anti-osteoporotic effects. However, the underlying mechanism of 25R-inokosterone in the treatment of osteoporosis is unknown.

Surgical treatments of metastatic bone disease of the hip joint: a scoping review protocol.

Introduction: Metastatic disease of the hip causes severe pain and is a serious threat to the patient's motor function. Surgery is required, but the actual efficacy is unclear, and there are many concerns for both patients and doctors. The purpose of this protocol is to conduct a scoping review for helping decisions of the intended audience.

Review of glass-ceramics: Solidification of toxic elements and durability.

The adverse effects of hazardous solid wastes on the environment are increasing, making green disposal a global priority. Glass-ceramics, multiphase composite materials comprising microcrystalline and glass phases, are recognized for their chemical stability, excellent mechanical properties, and wear resistance. Owing to their ability to solidify toxic elements and produce high-performance products, glass-ceramics play a crucial role in the green and valuable utilization of hazardous wastes.

The imbalance of pulmonary Th17/Treg cells in BALB/c suckling mice infected with respiratory syncytial virus-mediated intestinal immune damage and gut microbiota changes.

Unlabelled: The immune response induced by respiratory syncytial virus (RSV) infection is closely related to changes in the composition and function of gastrointestinal microorganisms. However, the specific mechanism remains unknown and the pulmonary-intestinal axis deserves further study. In this study, the mRNA levels of ROR-γt and Foxp3 in the lung and intestine increased first and then decreased.

Expectancy-Value Motivation and Physical Activity- and Health-Related Outcomes among At-Risk Children and Adolescents.

Despite a large amount of research having been done to examine and promote physical activity and health among adolescents and children, relatively little attention has been paid attention to underrepresented populations. In this study, we investigated the relationships between expectancy-value motivation and physical activity- and health-related outcomes among a group of at-risk boys at a summer sports camp. The total participants included 107 boys (M = 11.

Global Accelerometer-derived Physical Activity Levels from Preschoolers to Adolescents: A Multilevel Meta-analysis and Meta-regression.

Background: Global level physical activity surveillance studies were primarily based on self-report data that could generate inaccurate results.

Purpose: To investigate global accelerometer-measured daily moderate to vigorous physical activity (MVPA) changes from preschool age to adolescence as well as gender differences in MVPA while adjusting for the geographic regions and major MVPA cut points.

Methods: A comprehensive search was conducted through August 2020 that includes 30 databases such as Academic Search Ultimate, Child Development & Adolescent Studies, Education Full Text, ERIC, General Science, PsycINFO, ScienceDirect, and SPORTDiscuss.

Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarker.

SARS-CoV-2 and its mutant strains continue to rapidly spread with high infection and fatality. Large-scale SARS-CoV-2 vaccination provides an important guarantee for effective resistance to existing or mutated SARS-CoV-2 virus infection. However, whether the host metabolite levels respond to SARS-CoV-2 vaccine-influenced host immunity remains unclear.

The 3 × 2 achievement goal model and its relation to students' persistence/effort in college physical activity classes.

This study examined (1) the validity and reliability of the 3 × 2 achievement goal questionnaire (3 × 2 AGQ) in a college physical activity (PA) setting, and (2) relationships between achievement goals and students' persistence/effort. : Participants were 556 students ( = 20.31 years,  = 1.

Longitudinal Stability and Change in Young Students' Mastery-Approach Goals for Running.

In the present study, we examined the longitudinal stability and change in mastery-approach goals for running as offered in regularly scheduled physical education (PE) and athletics classes in the United States. There were five waves of data collection from 806 students (431 boys; 375 girls) who were tracked from fourth to eighth grade while participating in running activities in PE or athletics classes. We assessed the participants' mastery-approach goals using four items on a 5-point scale.

Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitus.

Background: NLRP3 and NLRP1 inflammasomes signaling pathways may play an important role in the development and progression of type 1 diabetes mellitus (T1DM). However, relative research is rare.

Methods: The blood mononuclear cells (PBMCs) and granulocytes (GCs) were collected from T1DM patients.

Procalcitonin and C-reactive protein in urinary tract infection diagnosis.

Background: Urinary infections are a common type of pediatric disease, and their treatment and prognosis are closely correlated with infection location. Common clinical manifestations and laboratory tests are insufficient to differentiate between acute pyelonephritis and lower urinary tract infection. This study was conducted to explore a diagnostic method for upper and lower urinary tract infection differentiation.