Mendelian randomization analysis of lipids traits and lipid-lowering drug-targets in relation to cognitive status.

Background: Cognitive impairment is increasingly prevalent among older adults, posing a major public health challenge. While lipid-lowering medications are widely used to manage dyslipidemia in this population, the causal relationship between lipid levels and cognitive function remains unclear. This study investigates genetically- predicted lipid traits, lipid-lowering drug-targets, and their associations with cognitive status.

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis-Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis.

The peripheral immune system contributes to the development of sepsis-induced cardiomyopathy. However, the underlying mechanisms linking central immune cells and neurons to sepsis-induced cardiomyopathy remain to be clarified. Here, acute sepsis is induced by cecal ligation puncture (CLP), and pharmacological and RNAi interventions are administered to the thoracic spinal cord via intrathecal injection.

Effects of motion sickness patch on postoperative nausea and vomiting in female patients undergoing thyroid surgery: a randomized clinical trial.

Background: This study aims to investigate whether the application of motion sickness patch can effectively reduce the incidence of PONV (Postoperative nausea and vomiting) in female patients undergoing thyroid surgery.

Methods: One hundred and sixty-two female patients undergoing thyroid surgery were randomly assigned into motion sickness patch group and control group. Both groups received standard prophylactic antiemetic therapy with intravenous dexamethasone (8 mg) and palonosetron (0.

Associations between metabolic syndrome and depression, and the mediating role of inflammation: Based on the NHANES database.

Background: Individuals with metabolic syndrome (MetS) have an increased risk of depressive symptoms, with inflammation hypothesized to mediate this association. This study used data from the National Health and Nutrition Examination Survey (NHANES) (2015-2020) to investigate the relationship between MetS and depression and assess the mediating role of inflammatory markers.

Methods: This cross-sectional study included 20,520 participants.

Integration of transcriptional and epigenetic regulation of TFEB reveals its dual functional roles in Pan-cancer.

Transcription factor EB (TFEB) mainly regulates the autophagy-lysosomal pathway, associated with many diseases, including cancer. However, the role of TFEB in pan-cancer has not been investigated systematically. In this study, we comprehensively analyzed TFEB targets under three stresses in Hela cells by cross-validation of RNA-seq and ChIP-seq.

Dietary capsaicin attenuates cardiac injury after myocardial infarction in type 2 diabetic mice by inhibiting ferroptosis through activation of TRPV1 and Nrf2/HMOX1 pathway.

Background: Type 2 diabetes mellitus (T2DM) is a major 21st-century epidemic. T2DM elevates the risk of myocardial infarction and heart failure while also reducinges survival rates. Recently Ferroptosis has been found to be involved in the development of various cardiovascular diseases.