Prognosis of Breast Cancer in Women in Their 20s: Clinical and Radiological Insights.

We analyzed clinical and radiological characteristics and prognostic factors specific to young patients with breast cancer (YBC) aged <30 years. This retrospective study included 132 women aged <30 years who underwent breast surgery between 2008 and 2013. The clinical and radiological findings of the patients were examined and compared according to recurrence or death status at follow-up.

Long-term prognostic value of myocardial perfusion scintigraphy in patients with suspected coronary artery disease: systematic review and meta-analysis.

Background: Long-term outcome of contemporary myocardial perfusion scintigraphy (MPS) has not been assessed systematically.

Objective: To evaluate the association between results of MPS and long-term outcomes for patients with suspected coronary artery disease (CAD).

Methods: Electronic databases were searched for Randomised controlled trials evaluating long-term outcome (≥12 months) of MPS in patients with suspected of CAD since year 2000.

Reverse translational approach to clarify the strong potency of enavogliflozin, a novel sodium-glucose cotransporter 2 inhibitor.

Enavogliflozin is a novel sodium-glucose cotransporter (SGLT2) inhibitor approved by the Korea Ministry of Food and Drug Safety for the treatment of type 2 diabetes. Clinical trials have demonstrated that enavogliflozin provides superior blood glucose-lowering effects and urinary glucose excretion (UGE) at a low dose of 0.3 mg compared with 10 mg of dapagliflozin.

Fermented Morinda citrifolia extract improves late-onset hypogonadism in aged rats.

Background: Late-onset hypogonadism (LOH) is an age-associated condition characterized by a progressive decline in testosterone levels. It manifests as reduced libido, infertility, muscle loss, and cognitive impairment in middle-aged men. Although testosterone replacement therapy is effective, its associated side effects highlight the need for safer alternatives.

Trends and management of acute respiratory failure in hospitalized patients: a multicenter retrospective study in South Korea.

Background: Acute respiratory failure (ARF) is the leading cause of hospitalization and is associated with in-hospital mortality. This study aimed to elucidate the epidemiology and clinical outcomes of ARF.

Methods: We retrospectively screened patients admitted to three hospitals in South Korea between January 2018 and December 2022.

Effect of electroencephalography-based motor imagery neurofeedback on mu suppression during motor attempt in patients with stroke.

Objective: The primary aim of this study was to explore the neurophysiological effects of motor imagery neurofeedback using electroencephalography (EEG), specifically focusing on mu suppression during serial motor attempts, and to assess its potential benefits in patients with subacute stroke.

Methods: A total of 15 patients with hemiplegia following subacute ischemic stroke were prospectively enrolled in this randomized cross-over study. This study comprised two experiments: neurofeedback and sham.

The association of ethnicity and migration status with agenda for change pay band in National Health Service healthcare workers: Results from the United Kingdom Research study into Ethnicity and Coronavirus Disease 2019 (COVID-19) Outcomes in Healthcare workers (UK-REACH).

Objectives: Ethnic minority and migrant healthcare workers (HCWs) constitute 24% of the UK's National Health Service. Migration status, often overlooked in Human Resources records, is associated with their placement within the Agenda for Change (AfC) pay bands. Therefore, we analysed the association between ethnicity, migration status, and AfC pay bands using data from the UK-REACH cohort study.

Surveillance Outcomes by Imaging Methods in the First 5 Years After Breast Cancer Surgery.

Objective: To compare the outcomes of imaging methods (mammography alone, ultrasound [US] alone, mammography combined with US, and magnetic resonance imaging [MRI]-based examination) for surveillance during the first 5 years after breast cancer surgery.

Materials And Methods: This retrospective cohort study analyzed the medical records of patients who underwent breast cancer surgery at a single institution between January 2011 and December 2015. Imaging surveillance was performed at 6-month or 1-year intervals during the first 5 years.

Thrombospondin-1 modulation by Bifidobacterium spp. mitigates lung damage in an acute lung injury mouse model.

Unlabelled: Our study shows that Bifidobacterium spp. supplementation reduces lung damage in acute lung injury by enhancing immune cell activity and restoring thrombospondin-1 levels, offering a promising therapeutic approach for the treatment of ALI/ARDS.

Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are critical conditions characterized by severe lung inflammation and damage, often exacerbated by mechanical ventilation.

Digital mammography with AI-based computer-aided diagnosis to predict neoadjuvant chemotherapy response in HER2-positive and triple-negative breast cancer patients: comparison with MRI.

Objective: To investigate whether digital mammography (DM) with artificial intelligence-based computer-aided diagnosis (AI-CAD) predicts pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor 2 (HER2)-positive and triple-negative (TN) breast cancers and compare performance with dynamic contrast-enhanced (DCE)-MRI.

Materials And Methods: In this single-center study, patients who underwent NAC and surgery for HER2-positive or TN cancers between September 2020 and August 2021 were retrospectively selected to develop prediction models for pCR after NAC. From a prospective ASLAN (Avoid axillary Sentinel Lymph node biopsy After Neoadjuvant chemotherapy) trial, HER2-positive and TN cancer patients who underwent NAC and surgery between December 2021 and July 2022 were prospectively selected for model validation.

HSP90 interacts with VP37 to facilitate the cell-to-cell movement of broad bean wilt virus 2.

The systemic spread of viruses in plants requires successful viral cell-to-cell movement through plasmodesmata (PD). Viral movement proteins (MPs) interact with cellular proteins to modify and utilize host transport routes. Broad bean wilt virus 2 (BBWV2) moves from cell to cell as a virion through the PD gated by VP37, the MP of BBWV2.

Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis.

Background: Sepsis, characterized by a dysregulated host response to infection, often leads to organ dysfunction, and vascular endothelial dysfunction plays a central role. The erythropoietin-producing hepatocellular carcinoma (Eph)A2 receptor is associated with increased vascular permeability; however, the developmental endothelial locus-1 (Del-1), has contrasting effects on endothelial function. Hence, we examined their potential as biomarkers of sepsis.

Comparative Analysis of Automated and Handheld Breast Ultrasound Findings for Small (≤1 cm) Breast Cancers Based on BI-RADS Category.

: This study aimed to compare ultrasound (US) findings between automated and handheld breast ultrasound (ABUS and HHUS, respectively) in small breast cancers, based on the breast imaging reporting and data system (BI-RADS) category. : We included 51 women (mean age: 52 years; range: 39-66 years) with breast cancer (invasive or DCIS), all of whom underwent both ABUS and HHUS. Patients with tumors measuring ≤1 cm on either modality were enrolled.

Bariatric surgery and HIV: Joint venture between family, primary care, and HIV physicians.

We report a case of a 49-year-old female with a history of HIV infection for 12 years. The patient had excellent compliance with antiretroviral medications, raltegravir 400 mg twice daily and truvada once daily for HIV. Over the years, she maintained an undetectable viral load with a CD4+ count >200 cells/μL.

Improvement of Late-Onset Hypogonadism Symptoms of Fermented Extract in TM3 Leydig and TM4 Sertoli Cells.

Background/objectives: Late-onset hypogonadism (LOH), characterized by declining testosterone levels with age, negatively affects the health of men, causing physical, psychological, and sexual dysfunction. Conventional testosterone replacement therapies have side effects, which has led to interest in natural alternatives. We investigated the effects of a standardized fermented extract (FME) on oxidative stress-induced damage in TM3 Leydig and TM4 Sertoli cells.

Factors Associated with Malignant Biopsy Results for Newly Detected Lesions within One Year after Breast Cancer Surgery.

Rationale And Objectives: This study aimed to identify the factors associated with malignant biopsy results for new lesions within one year after breast cancer surgery.

Materials And Methods: This retrospective study included 192 lesions from 186 patients who underwent biopsy for newly developed breast lesions within one year of breast cancer surgery. All patients underwent breast ultrasound (US) at 6 months and breast US with mammography one year after surgery.

Assessment of Nonmass Lesions Detected with Screening Breast US Based on Mammographic Findings.

Background Breast nonmass lesions (NMLs) are observed at screening and diagnostic US. However, knowledge is limited on imaging features of NMLs at screening US. Purpose To identify features of NMLs at screening US that are suspicious for malignancy based on mammographic findings.

Long-term prognostic value of contemporary stress echocardiography in patients with suspected or known coronary artery disease: systematic review and meta-analysis.

Background: Long-term outcome of contemporary stress echocardiography has not been systematically assessed.

Objective: To evaluate the association between results of stress echocardiography and patients' outcomes with suspected coronary artery disease using randomised controlled trials.

Methods: Multiple electronic databases were searched for studies evaluating long-term outcome (>12 months) of stress echocardiography in patients suspected of coronary artery disease since year 2000.

Ultrafast sequence-based prediction model and nomogram to differentiate additional suspicious lesions on preoperative breast MRI.

Objectives: To investigate whether ultrafast sequence improves the diagnostic performance of conventional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiating additional suspicious lesions (ASLs) on preoperative breast MRI.

Materials And Methods: A retrospective database search identified 668 consecutive patients who underwent preoperative breast DCE-MRI with ultrafast sequence between June 2020 and July 2021. Among these, 107 ASLs from 98 patients with breast cancer (36 multifocal, 42 multicentric, and 29 contralateral) were identified.

Usefulness of Impulse Oscillometry in Predicting the Severity of Bronchiectasis.

Background: Bronchiectasis is a chronic respiratory disease that leads to airway inflammation, destruction, and airflow limitation, which reflects its severity. Impulse oscillometry (IOS) is a non-invasive method that uses sound waves to estimate lung function and airway resistance. The aim of this study was to assess the usefulness of IOS in predicting the severity of bronchiectasis.

Effect of the sodium-glucose cotransporter-2 inhibitor, DWP16001, as an add-on therapy to insulin for diabetic dogs: A pilot study.

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of anti-hyperglycaemic agents.

Objective: This study aimed to evaluate the safety and the adjuvant glycaemic control effect of an SGLT2 inhibitor, DWP16001, in diabetic dogs receiving insulin treatment.

Methods: Nineteen diabetic dogs receiving insulin treatment (NPH, porcine lente and glargine insulin) were divided into two groups according to dosing frequency: DWP TOD group (n = 10) and DWP SID group (n = 9).