Publications by authors named "Jennifer M Yamamoto"
Predicting dysglycaemia in individuals with gestational diabetes immediately postpartum using continuous glucose monitoring (PREDISPOSE) in a multicentre prospective cohort study in Canada: a study protocol.
BMJ Open
July 2025
Introduction: Gestational diabetes is a common metabolic disorder in pregnancy which identifies a substantial increased risk of future diabetes. Despite this risk, many individuals are not screened for dysglycaemia in the postpartum period. Continuous glucose monitoring (CGM) is an evolving technology that provides details of an individual's glucose levels throughout the day; however, it has not yet been evaluated as a screening tool for postpartum dysglycaemia.
View Article and Find Full Text PDFAssociation Between Insulin Regimen and Risk of Severe Hypoglycemia and Mortality in Adults With Type 2 Diabetes: A Large, Population-based, Retrospective Cohort Study.
Can J Diabetes
June 2025
Objectives: Our aim in this study was to compare severe hypoglycemia and all-cause mortality between insulin regimens in people with type 2 diabetes on insulin.
Methods: This retrospective cohort study included individuals with type 2 diabetes who received a first insulin prescription from April 2007 to December 2018 in Manitoba, Canada. We used Cox proportional hazard regression models to compare risks and time to events for severe hypoglycemia and all-cause mortality among insulin regimens, adjusting for covariates.
Background: Lactation Consultants (LC) at Health Sciences Centre (HSC) and St Boniface General Hospitals (SBGH) supported the lactation of 2/3 of Manitoba newborns since 1994. The LC program in HSC was discontinued in 2018. Its impact on infant feeding in the province remains unclear.
View Article and Find Full Text PDFStudy Question: What is the validity of published administrative health data case definitions of polycystic ovary syndrome (PCOS) compared with reference standards?
Summary Answer: Due to the limited number of eligible studies, drawing definitive conclusions is challenging; however, this review highlights significant gaps and variability in current PCOS case definitions, underscoring the need for standardized case definitions in future research.
What Is Known Already: Administrative health data offer the opportunity to evaluate health outcomes and disease epidemiology at a population-level. Currently, the validity of existing administrative health data case definitions for PCOS is unknown.
Objectives: The rising prevalence of gestational diabetes (GDM) presents a challenge to health-care systems. Virtual care has emerged as a potential solution to alleviate this burden, but limited data exist on its effectiveness. In this study, we evaluated maternal and neonatal outcomes in individuals with GDM managed with virtual care vs in-person care.
View Article and Find Full Text PDFArticle Synopsis
- The study explored how maternal glucose levels affect the composition and volume of breast milk in mothers with type 1 diabetes (T1D).
- Researchers collected midfeed breast milk samples from 11 mothers with T1D and compared them with samples from five mothers without T1D.
- Results indicated that higher maternal glucose levels were linked to increased glucose and fructose in the breast milk, while the volume consumed by infants wasn't related to maternal glucose.
- Additionally, mothers with T1D had higher levels of breast milk glucose and leptin compared to those without T1D.
Article Synopsis
- There has been a significant increase in gestational diabetes incidence in Manitoba, rising from 1.3% to 8.6% between 1981 and 2019, particularly after 2010.
- The most considerable increases were noted among urban residents, people over 35 years old, and those in higher socioeconomic status (SES) groups.
- Geospatial mapping indicates that neighborhoods with higher proportions of recent immigrants also experienced a steeper rise in gestational diabetes cases, highlighting the need for more research on screening practices.
Use of continuous glucose monitoring and hybrid closed-loop therapy in pregnancy.
Diabetes Obes Metab
December 2024
Continuous glucose monitoring (CGM) has led to a paradigm shift in the management of pregnant women with type 1 diabetes (T1D), with improved glycaemic control, less hypoglycaemia and fewer pregnancy complications. Data on CGM use in pregnant women with type 2 diabetes (T2D) are limited. A large randomized controlled trial (RCT) on CGM use in people with T2D in pregnancy is ongoing.
View Article and Find Full Text PDFObjectives: Closed-loop insulin delivery has the potential to offer women with type 1 diabetes a break from intense diabetes self-care efforts postpartum. Our aim in this study was to explore the views and opinions of hybrid closed-loop users and their partners in the first 24 weeks postpartum.
Methods: This qualitative study was embedded in a controlled study of women with type 1 diabetes randomized to closed-loop insulin delivery (MiniMed 670G or 770G; Medtronic, Minneapolis, Minnesota, United States) or sensor-augmented pump use for 1 to 11 weeks 6 days postpartum, with all on closed-loop delivery from 12 to 24 weeks postpartum.
Objective: Despite the well-recognized association between pre-existing diabetes mellitus and stillbirth or perinatal mortality, there remain knowledge gaps about the strength of association across different populations. The primary objective of this systematic review and meta-analysis was to quantify the association between pre-existing diabetes and stillbirth or perinatal mortality, and secondarily, to identify risk factors predictive of stillbirth or perinatal mortality among those with pre-existing diabetes.
Data Sources: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials from inception to April 2022.
Article Synopsis
- The study investigates how breastfeeding affects maternal glucose levels in women with type 1 diabetes using different insulin therapy methods.
- It analyzes data from infant-feeding diaries and continuous glucose monitoring over three time points postpartum, focusing on glucose changes during breastfeeding episodes.
- Results show a slight drop in maternal glucose levels after nighttime breastfeeding, particularly more significant with open-loop insulin therapy than with closed-loop therapy, which had a muted response.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in females. Modest weight loss improves reproductive and metabolic PCOS features. While lifestyle modifications and pharmacotherapies remain first-line weight loss strategies, bariatric surgery is emerging as a potentially effective treatment.
View Article and Find Full Text PDFArticle Synopsis
- A systematic review is a detailed procedure used to gather and analyze existing research related to a specific question, often summarized using qualitative or quantitative methods like meta-analysis.
- The rise of systematic reviews and meta-analyses (SRMAs) in scientific research, including diabetes studies, has highlighted their importance in evidence-based medicine, but also raised concerns about the quality and accuracy of some reviews.
- This article aims to improve understanding of SRMAs by discussing their process, common mistakes, best practices, recent advancements, and strategies for enhancing their quality, alongside essential considerations for those involved in creating or evaluating SRMAs.
A Randomized Trial of Closed-Loop Insulin Delivery Postpartum in Type 1 Diabetes.
Diabetes Care
December 2023
Objective: This study aimed to evaluate the efficacy of closed-loop insulin delivery postpartum.
Research Design And Methods: In this open-label, randomized controlled trial, postpartum individuals with type 1 diabetes were randomized to hybrid closed-loop insulin delivery with the MiniMed 670G/770G system in automode or sensor-augmented pump therapy in the first 12-weeks postpartum followed by a continuation phase with closed-loop insulin delivery for all until 24 weeks postpartum.
Results: Eighteen participants (mean ± SD age 32 ± 3.
Article Synopsis
- Precision medicine is an evolving approach in healthcare that aims to enhance decision-making and health outcomes, particularly in managing diabetes, which poses serious health risks for millions globally.
- The second international consensus report on precision diabetes medicine reviews current findings on prevention, diagnosis, treatment, and prognosis across different forms of diabetes, highlighting the potential for translating research into clinical practice.
- The report also identifies knowledge gaps and sets out key milestones for better clinical implementation, emphasizing the need for standards addressing cost-effectiveness, health equity, and accessibility in treatment options.
Precision gestational diabetes treatment: a systematic review and meta-analyses.
Commun Med (Lond)
October 2023
Article Synopsis
- Gestational Diabetes Mellitus (GDM) happens in about 1 out of 7 pregnancies worldwide and can be risky for both moms and babies, making effective treatment really important.
- The study looked for specific signs that could help doctors give better, personalized treatments for GDM, but there aren't many studies on lifestyle changes to help manage it.
- The researchers found some early indicators from routine check-ups that could help identify who might need stronger medications sooner, but more research is needed to explore other potential markers.
Objectives: The prevalence of type 2 diabetes (T2D) is increasing and Indigenous populations are at highest risk. Canadian data are crucial for health planning.
Methods: Population-based, de-identified, linked databases were used to calculate the incidence and prevalence of T2D for registered adult First Nations Manitobans and all other adult Manitobans from 2011-2012 to 2016-2017.
Article Synopsis
- - First Nation individuals in Canada have a notably higher prevalence of type 2 diabetes during pregnancy, leading to increased risks of adverse outcomes compared to other Manitoban women with the same condition.
- - In a study involving 2181 females, it was found that First Nation mothers had significantly higher rates of stillbirth and perinatal death, as well as increased risks of neonatal complications like congenital malformations.
- - The findings highlight the need for further research to identify factors that contribute to or protect against pregnancy complications among First Nation individuals with type 2 diabetes.
Background: There is limited information regarding the association between missed appointments and neonatal outcomes for diabetes in pregnancy.
Study Methods: This retrospective live birth cohort included pregnant women with Type 1 or 2 diabetes who attended specialized clinics from 2008 to 2020. The association between at least one missed antenatal diabetes appointments and outcomes were assessed using logistic regression and reported as adjusted odds ratios (aOR) (95% confidence interval).