Item selection for the development and validation of a revised classification criteria for adult and juvenile idiopathic inflammatory myopathies: MyoROC project.

Objective: A revision of the 2017 EULAR-ACR myositis classification criteria, namely EULAR-ACR funded Myositis Revision of Classification (MyoROC) project, is currently underway involving a large international group of experts. In the first phase of this project, we identified additional items to be tested in the criteria.

Methods: We distributed an electronic survey to International Myositis Assessment and Clinical Studies (IMACS) members to identify new items.

Organizational Climate and Decision Aid Sustainability in Lupus Care: Mixed Methods Study.

Background: Digital decision aids (DAs) are increasingly used in health care to support shared decision-making and promote patient engagement. In the context of systemic lupus erythematosus (SLE), a complex autoimmune disease characterized by diverse symptoms and uncertain prognoses, DAs offer guidance to patients in navigating treatment risks and benefits. Although numerous studies have examined the initial implementation of evidence-based tools, there is limited evidence on the organizational factors that influence their long-term sustainability in clinical practice.

GRADE Concept Paper 9: Rationale and process for creating a GRADE Ontology.

Context: As the rate of research production accelerates, the ability to efficiently and unambiguously communicate judgements relating to the synthesis, evaluation, and use of scientific information becomes paramount.

Perspective: Scientific information can be viewed as a "layered infrastructure" of data, evidence, knowledge, and use. The GRADE approach serves as a de facto data standard in this infrastructure, reducing ambiguity in claims to knowledge (in the form of judgements of certainty in the evidence when answering research questions) and level of commitment to possible solutions to problems (in the form of strength of recommendations for interventions).

Accelerated Bachmann bundle area pacing for atrial resynchronization in patients with non-obstructive hypertrophic cardiomyopathy and heart failure with preserved ejection fraction: A randomized crossover trial.

Background: Inter-atrial block (IAB) can contribute to the worsening of diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF).

Objective: To determine the effects of accelerated Bachmann bundle area pacing (BBAP) in symptomatic patients with non-obstructive hypertrophic cardiomyopathy (nHCM), HFpEF, and IAB.

Methods: Prospective, randomized, patient-blinded crossover study in symptomatic patients with nHCM, HFpEF, and IAB.

Where, how, and how much? A multicenter cohort study of the relationship between lupus decision aid modality, place of administration, interruption and viewing completeness and patient-reported outcomes.

Objective: We assessed whether shared decision-making (SDM), and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE), differs by PtDA setting, modality, and the viewing experience.

Methods: Patients with SLE were invited to view a self-administered computerized SLE PtDA during regular clinic visits at 15 rheumatology clinics in an implementation trial. Patients completed a survey that included SDM measures including the decision-conflict (DCS), preparation for decision-making (PDM), and CollaboRATE scales; perceived patient acceptability, feasibility, and satisfaction.

Successful epicardial ablation of incessant left atrial tachycardia in a child with arrhythmia induced cardiomyopathy.

Incessant supraventricular tachycardias leading to arrhythmia induced cardiomyopathy (AIC) is not uncommon. We report one such case of an incessant multidrug resistant focal left atrial tachycardia (AT) in a child who presented with AIC. During electrophysiology study this tachycardia was localized to the left atrial appendage (LAA) but, endocardial ablation at this site caused only temporary suppression of arrhythmia.

Manual Validation of an Algorithm for Identifying Osteoarthritis within the Centralized Interactive Phenomics Resource of the Million Veteran Program.

Objective: This study aimed to validate an osteoarthritis (OA) phenotyping algorithm within the Million Veteran Program (MVP) using the United States (US) Department of Veterans Affairs (VA) Centralized Interactive Phenomics Resource (CIPHER).

Methods: A random sample of 213 veterans was analyzed sing ICD-9-CM/ICD-10-CM codes from a previously published algorithm (PMID:29559693). OA cases required two OA codes at least 30 days apart, while controls were excluded based on codes for conditions more common in OA patients, such as chondrocalcinosis and crystal arthropathies.

Testing for Causal Association between Serum Urate, Gout, and Prostatic Cancer in European Males.

Objective: To conduct a two-sample MR study including only men to test for a causal relationship between serum urate (SU) and gout and prostate cancer.

Methods: We used GWAS for SU, gout, and prostate cancer to generate exposure instrumental variables (IV) associated with gout and urate. We used 20 single nucleotide polymorphisms (SNPs) associated with gout but not urate for an IV representing the non-hyperuricemia (inflammatory) compartment of gout and we used four SNPs from loci containing urate transporter genes for an IV representing urate levels.

Novel C-3 and C-20 derived analogs of betulinic acid as potent cytotoxic agents: design, synthesis, and studies.

In this report, novel derivatives of betulinic acid were designed and synthesized by targeting the C-3-OH group and C-20 olefinic bond in an endeavour to develop potent antitumor agents. These analogs were screened for their anticancer activity against six different human cancer cell lines including breast cancer MCF-7, lung cancer A549, colon cancer HCT-116, leukemia MOLT-4, prostate carcinoma cell PC-3 and pancreatic cancer cell Miapaca-2 by MTT assay. Many derivatives displayed better cytotoxicity than the parent compound BA.

Hospital and patient factors predict length of stay in patients with osteoarthritis undergoing total primary hip replacement.

Objectives: Over 450,000 primary total hip arthroplasties (THA) are performed each year in the US, with osteoarthritis (OA) as the major indication for primary THA. We examined the association of patient, payer, hospital, and geographic factors with extended lengths of stay (eLOS) and increased hospital costs in primary THA.

Methods: We utilized the National Inpatient Sample (NIS) to identify patients with OA who underwent primary THA in 2019.

Rural-urban disparities in hospitalisation for myocardial infarction in systemic lupus erythematosus in the USA.

Objective: To assess whether rural-urban disparities exist in people with SLE for hospitalisation with myocardial infarction (MI).

Methods: We used the 2016-2019 US National Inpatient Sample data that contain all hospitalisation data. In people with a diagnosis of SLE, we assessed the multivariable adjusted ORs (aORs) to examine the association of rural patient residence with MI hospitalisation, while adjusting for demographics, payer, income, hospital characteristics and the Deyo-Charlson Comorbidity Index.

Rheumatoid arthritis and the risk of 90-day readmission after hospitalization for heart failure.

Aims: To determine the association of rheumatoid arthritis (RA) diagnosis on the risk of 90-day readmissions and in-hospital mortality during readmission episode within 90 days after index heart failure (HF) hospitalization.

Methods: We used the 2016-2019 U.S.

Medical Comorbidity and Male Sex Are Associated With Higher In-hospital Mortality for 90-Day Readmissions and Higher Readmission Rates After Nonelective Primary Total Hip Arthroplasty for Hip Fracture.

Purpose: To assess whether sex and comorbidity are associated with the risk of 90-day readmission and associated mortality after nonelective primary total hip arthroplasty (THA) for hip fracture in the United States.

Methods: We used the 2016-2019 US Nationwide Readmissions Database, a nationally representative dataset of readmissions, to examine 90-day readmission outcomes after primary nonelective THA with a primary diagnosis of hip fracture. Sex and medical comorbidity (Deyo-Charlson Comorbidity Index) were variables of interest.

Implementation outcomes of a patient decision-aid in a diverse population with systemic lupus erythematosus in 15 US rheumatology clinics.

Objective: The objective of this study was to examine the clinical outcomes during the implementation of a self-administered patient decision-aid (PtDA) for lupus.

Methods: We provided an effective computerized lupus PtDA in 15 rheumatology outpatient clinics 2019-2024 (including the COVID pandemic). We undertook Organizational Readiness to Implement Change Surveys (ORICs) and Team Learning and Psychological Safety Surveys (TLPSSs) at baseline.

Time required to implement a computerized patient decision aid for lupus in outpatient visits.

Background: Patient decision aids have the potential to lower decision conflict for patients and to improve patient-physician communication. However, uptake of decision aids has been poor, in part because the time required to incorporate these into clinical practice is not well understood.

Objective: To estimate the time required for a rheumatology clinic to implement a validated decision aid for patients with lupus.

Translational genomics of osteoarthritis in 1,962,069 individuals.

Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed.

Molecular mechanisms underlying TXNIP's anti-tumor role in breast cancer, including interaction with a novel, pro-tumor partner: CAST.

Thioredoxin-interacting protein (TXNIP) plays a pivotal role in glucose metabolism and redox signaling. Its emerging function as a potent suppressor of cell proliferation in various cancer contexts underscores its importance in cancer development. In a previous study, we found TXNIP activation by UNC0642, an inhibitor of histone methyltransferase G9A, significantly inhibited MDA-MB-231 breast cancer cell proliferation in vitro and tumor growth in vivo.

Rural-Dwelling Patients With Rheumatoid Arthritis and Risk of Myocardial Infarction Hospitalization: An Observational Study Using the National Inpatient Sample.

Objective: To assess whether there is a rural-urban and income-related disparity in the incidence and outcomes of hospitalization for myocardial infarction (MI) in patients with rheumatoid arthritis (RA).

Methods: We used the 2016-2019 US National Inpatient Sample (NIS) data and selected all patients with RA. Rural vs urban residential status was identified using NIS classifications.

Prevalence and associated risk factors of hypertension in rural and urban areas of Punjab: A cross-sectional study.

Context: Hypertension is a growing concern worldwide, particularly in developing countries. In India, it significantly contributes to morbidity and mortality. Various states have reported an increasing incidence of hypertension, underscoring the need to assess its prevalence and associated risk factors.

Core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition disease: OMERACT delphi survey to establish consensus.

Objective: To agree on important domains for the Outcome Measures in Rheumatology (OMERACT) core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition (CPPD) disease.

Methods: Patient research partners (PRPs) and other participants (mainly clinicians and researchers) contributed to three rounds of a consensus survey using Delphi methodology. Consensus was defined if ≥70% of both patients and other participants scored the domain as 'critically important domain to include'.

Core domain set for studies of acute calcium pyrophosphate crystal arthritis: OMERACT delphi survey to establish consensus.

Objective: To identify potential domains for the Outcome Measures in Rheumatology (OMERACT) core domain set for studies of an individual flare of acute calcium pyrophosphate (CPP) crystal arthritis.

Methods: Patient research partners (PRPs) and other participants (mainly clinicians and researchers) completed three rounds of survey using Delphi methodology. Consensus was defined as ≥ 70 % of both PRP and other participants groups rated the domain as a 'critically important domain to include'.

Are there rural-urban disparities in cardiovascular disease hospitalization and other outcomes in people with gout? A nationwide U.S. study.

Objective: The objective of this study was to assess whether rural vs urban patient residence is associated with the risk of myocardial infarction (MI) hospitalization and other outcomes in people with gout.

Methods: We used the 2016-2019 U.S.

Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis.

Objective: This study aims to evaluate the association between patient sex and discharge disposition as well as inpatient mortality following elective primary total hip arthroplasty (THA) for osteoarthritis (OA) in the United States.

Methods: This study used the 2016-2019 US National Inpatient Sample, a nationally representative dataset, to conduct a cross-sectional study. Adjusted odds ratios and 95% confidence intervals (CIs) were calculated to assess the association of sex with discharge disposition and in-hospital mortality after elective primary THA for OA, adjusting for demographics, comorbidity, social determinants of health (income, insurance payer), hospital characteristics (bed size, location/teaching status, region, control), and postprocedural complications (for mortality and discharge disposition).