The Utility of Cervical Vertebral Maturation Method for Staging Skeletal Growth and Curve Progression in Patients with Adolescent Idiopathic Scoliosis.

Background: Cervical vertebral maturation (CVM) is a skeletal maturity method that can be assessed routinely on whole spine radiographs to minimize radiation exposure. Originally used in orthodontics, its role in staging adolescent growth spurt and curve progression in adolescent idiopathic scoliosis (AIS) remains unclear. The aim of this study was to investigate growth rates across CVM stages, its cutoff for indicating peak growth (PG) versus growth cessation (GC), and its relationship with coronal curve progression.

OLSIA: Open Lumbar Spine Image Analysis - A 3D Slicer Extension for Segmentation, Grading, and Intervertebral Disc Height Index with Multi-Dataset Validation.

Study Design: Retrospective and cross-sectional study.

Objective: The study aims to develop an open software for lumbar spine image analysis enabling no-code approach to lumbar spine segmentation, grading, and intervertebral disc height index (DHI) calculations with robust evaluation of the application on six external datasets from diverse geographical regions.

Summary Of Data: The datasets used include NFBC1966 (Finland), HKDDC (Hong Kong), TwinsUK (UK), CETIR (Spain), NCSD (Hungary), SPIDER (Netherlands), and Mendeley (global).

Osteoblast-CD4 CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age-Related Bone Loss.

The dynamic production and clearance of senescent osteoblasts affects bone homeostasis and health. However, the relationship between senescent osteoblasts and the immune system remains unclear. Here, a landscape of the interaction between immune cells and osteoblasts through spatial analysis of the bone microenvironment is presented.

Chatbot-delivered structured psychological intervention (SPI-Bot) for teenagers with adolescent idiopathic scoliosis in Hong Kong: protocol for a pilot randomised controlled trial.

Introduction: Adolescent idiopathic scoliosis (AIS) often imposes a significant psychological burden on teenagers. Cognitive and behavioural strategies have demonstrated the potential to alleviate these challenges. Chatbots, with their real-time interaction capabilities, provide a promising and accessible approach to delivering psychological interventions for young people.

The perioperative complications of vertebral body tethering : prevalence and predictive factors.

Aims: There is little information in the orthopaedic literature about the rate of perioperative complications of vertebral body tethering (VBT), in the surgical management of patients with adolescent idiopathic scoliosis. The aim of this study was to determine the rate of these complications and to investigate the corresponding predictive factors.

Methods: This was a prospective single-centre study involving all patients who underwent VBT between February 2019 and October 2024.

Factors contributing to bracing success in juvenile idiopathic scoliosis and current limitations : a systematic review and meta-analysis.

Aims: There is a general lack of guidelines on nonoperative treatment in juvenile idiopathic scoliosis (JIS). This review aims to explore factors determining bracing success in JIS and to identify limitations in current literature.

Methods: A literature search was conducted according to the PRISMA 2020 guidelines.

Psychometric Validation and Responsiveness of the Cross-culturally Adapted Traditional Chinese Version of the Early-onset Scoliosis Self-report Questionnaire (EOSQ-SELF).

Background: Patients with early-onset scoliosis (EOS) can experience compromised health-related quality of life (HRQoL). EOSQ-SELF was developed to assess HRQoL directly from patients, yet its responsiveness remains unclear. We aimed to evaluate the psychometric properties and responsiveness of the cross-culturally adapted traditional Chinese version of EOSQ-SELF.

Prevalence and Risk Factors for Postoperative Neurological Complications in Spinal Deformity Surgery: A Systematic Review and Proportional Meta-Analysis.

Objective: To investigate the incidence of postoperative neurological complications among patients who underwent spinal deformity surgery and to determine the significant risk factors for postoperative neurological complications.

Methods: Six databases PubMed, Web of Science, Scopus, MEDLINE, Embase, and Cochrane Library have been searched to identify observational studies from inception until January 2025. Inclusion criteria were patients aged ≥10 years with postoperative neurological complications after spinal deformity surgery.

Translational genomics of osteoarthritis in 1,962,069 individuals.

Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed.

Exploring the potential relationships between idiopathic scoliosis and various multifactorial diseases: a systematic scoping review.

Background: Although the etiology of adolescent idiopathic scoliosis (AIS) remains largely elusive, it is widely recognized as a multifactorial condition shaped by both genetic predispositions and environmental influences. This review seeks to explore the intricate relationships between idiopathic scoliosis and its associated comorbidities, with the goal of advancing our understanding of this multifaceted disorder.

Methods: Primary studies involving human subjects diagnosed with idiopathic scoliosis and presenting comorbid conditions were included.

Conservative and newer drug treatment for degenerative cervical myelopathy.

Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic spinal cord dysfunction in adults worldwide. Conservative treatments, such as physical therapy, activity modification, cervical traction, and the use of cervical collars, have been employed primarily for symptomatic relief in mild cases or for patients deemed unfit for surgery. Advances in our understanding of the molecular pathways involved in neuroinflammation and neuronal injury in DCM have spurred the development of newer pharmacological treatments aimed at neuroprotection and inflammation control.

How Accurate Are Fulcrum Bending Radiographs in Estimating Postoperative Outcomes in Adolescent Idiopathic Scoliosis? A Systematic Review and Meta-analysis.

Background: Fulcrum bending radiographs can be used to assess coronal flexibility in patients with adolescent idiopathic scoliosis (AIS) to estimate postoperative correction. To obtain fulcrum bending radiographs, patients are passively bent over a radiolucent fulcrum at the apex of the curve. Available studies have disagreed about the accuracy in estimating postoperative correction, although these studies differed in terms of patients' baseline characteristics as well as other methods.

Enhancing Orthotic Treatment for Scoliosis: Development of Body Pressure Mapping Knitwear with Integrated FBG Sensors.

Bracing is a widely used conservative treatment for adolescent idiopathic scoliosis (AIS) patients, yet there is no consensus on the optimal amount of force applied. Although a number of different sensors have been developed to continuously monitor the applied pressure and force, they have several limitations, including inadequate overall force distribution and displacement. They also cause discomfort with limited wearability.

Lateral view fulcrum bending radiographs predict postoperative hypokyphosis after selective thoracic fusion in adolescent idiopathic scoliosis.

Study Design: A retrospective observational study.

Purpose: To identify the surgical and preoperative risk factors on fulcrum bending radiographs for postoperative hypokyphosis in patients with Lenke 1 adolescent idiopathic scoliosis (AIS).

Overview Of Literature: AIS is associated with thoracic hypokyphosis.

Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells.

Denosumab, a RANK ligand inhibitor, is primarily used to prevent osteoclastogenesis in the treatment of conditions such as osteoporosis, bone metastasis, and giant cell tumor of bone (GCTB). RANK ligand also plays an important role in immunity by activating NF-κB and its target genes, including the osteopontin-coding gene SPP1 (also known as OPN), which is linked to CXCL9:SPP1 macrophage polarization and prognosis. In this study, we explored an additional role of denosumab in enhancing antitumor immunity in patients.

Sensitivity of intraoperative electrophysiological monitoring for scoliosis correction in identifying postoperative neurological deficits: a retrospective chart review of the Scoliosis Research Society morbidity and mortality database.

Background: Surgical intervention is the ultimate treatment for scoliosis, but iatrogenic spinal cord injury is one of the major concerns. Although intraoperative electrophysiological monitoring can aid in detecting and reducing postoperative neurological complications, its use is still controversial.

Methods: A retrospective chart review of 6,577 scoliotic patients who underwent surgery for curve correction with a reported complication was conducted.

Relationships of PedsQL 4.0 generic core scales with other validated HRQoL instruments in braced idiopathic scoliosis patients: An age and curve severity-specific analysis.

This study aims to investigate if the addition of PedsQL 4.0 generic core scales (PedsQL) with other validated instruments in day-to-day clinical context is feasible. Patients with idiopathic scoliosis who were undergoing brace treatment and aged 8-18 were asked to fill in the PedsQL 4.

A case series in vertebral body tethering results in improvement in coronal Cobb angle but deterioration in axial rotation: a 3-dimensional analysis.

Background: Vertebral body tethering (VBT) has shown improvements in coronal and sagittal plane correction in adolescent idiopathic scoliosis (AIS) patients, but axial correction over time remains unexplored. Three-dimensional (3D) spine reconstruction was used to analyse correctional changes in all spinal planes post VBT surgery.

Case Description: AIS subjects who underwent thoracic VBT surgery with a minimum 2-year follow-up were assessed.

Current trends in intraoperative neurophysiological monitoring among Asia-Pacific countries: an Asia-Pacific Spine Society survey.

Study Design: A prospective web-based survey.

Purpose: Although intraoperative neurophysiological monitoring (IONM) is critical in spine surgery, its usage is largely based on the surgeon's discretion, and studies on its usage trends in Asia-Pacific countries are lacking. This study aimed to examine current trends in IONM usage in Asia-Pacific countries.

Normative values of spinal and peripheral proprioception in position sense among healthy adolescents and young adults.

Establishing normative values and understanding how proprioception varies among body parts is crucial. However, the variability across individuals, especially adolescents, makes it difficult to establish norms. This prevents further investigation into classifying patients with abnormal proprioception.

Current Status of Vertebral Body Tethering for Adolescent Idiopathic Scoliosis: An Umbrella Review.

Background: Adolescent idiopathic scoliosis (AIS) is a prevalent spinal deformity among teenagers worldwide. Vertebral body tethering (VBT) is an innovative, minimally invasive technique developed to address spinal curvature by modulating vertebral growth. However, the existing body of evidence regarding the effectiveness and safety of VBT in treating AIS is fragmented and requires thorough consolidation and critical assessment.