Body Mass Index and Outcomes After Transcatheter Aortic Valve Replacement: Insights From the Transpacific-TAVR Registry.

Background: Whereas some studies suggest an "obesity paradox" with improved outcomes in obese patients following transcatheter aortic valve replacement (TAVR), the impact of pre-TAVR body mass index (BMI) and post-TAVR BMI changes on clinical and echocardiographic outcomes remains unclear.

Objectives: This study sought to evaluate the influence of BMI at the time of TAVR and subsequent BMI changes on clinical and echocardiographic outcomes in patients undergoing TAVR.

Methods: We included 1,339 patients with severe, native aortic stenosis from 2015 to 2019, stratified by BMI according to World Health Organization classifications, from an international registry.

On Neurocardiology Updates: an Interdisciplinary Field at the Intersection of Neurology and Cardiology.

Purpose Of Review: This review examines the evolving field of neurocardiology, tracing its development from early homeostatic theories to modern understandings of the bidirectional neural networks that link the heart and brain. We propose an integrative framework to explain neuro-cardiac interactions in health and disease, with a focus on clinical applications and emerging therapies.

Recent Findings: The neuro-cardiac axis comprises hierarchical neural networks, from the intrinsic cardiac nervous system to subcortical and cortical brain regions.

The Prognostic Value of Frailty in a Transcatheter Mitral Valve-in-Valve Cohort.

•MViV is effective for managing degenerative bioprosthetic mitral valves.•Frailty is a strong predictor of outcome for cardiac interventions.•Increasing frailty is predictive of poor outcomes post-MViV.

The Impact of Target Vessel Diameter on the Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry.

Background: The impact of target vessel diameter on outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study.

Aim: To compare the impact of target vessel diameter on CTO PCI outcomes.

Methods: We examined the association of vessel diameter with clinical, angiographic characteristics, and procedural outcomes of CTO-PCI in a large multicenter registry.

Transcatheter Aortic Valve Implantation in Very Low-Gradient Aortic Stenosis.

Background: Transcatheter aortic valve implantation (TAVI) is beneficial in low-flow, low-gradient aortic stenosis (LGAS) (mean pressure gradient [MPG] ​<40 mmHg). The benefit and outcomes of TAVI in very low-gradient aortic stenosis (VLGAS) patients (MPG <25 mmHg) are under-reported.

Methods: This retrospective cohort study analyzed 1173 patients with severe native valve aortic stenosis who underwent TAVI at a tertiary-care center between July 2012 and December 2021.

Device Therapy for Heart Failure With Preserved Ejection Fraction: The Problem, the Mechanism, the Device, the Trial.

Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome of epidemic proportions associated with elevation of left sided heart pressures despite a left ventricular ejection fraction (LVEF) of > 50%. 1 Patients with HFpEF have signs and symptoms of heart failure (HF) similar to patients with HF with reduced ejection fraction (HFrEF) and account for slightly greater than half of all patients with HF. 2 Prognosis for both HFpEF and HFrEF are similar and are markedly worse than those of the general population.

Obstructive sleep apnea syndrome in chronic total occlusion percutaneous coronary intervention; insights from the PROGRESS-CTO registry.

Objective: To examine the outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in patients with obstructive sleep apnea syndrome (OSAS).

Methods: We compared the procedural characteristics and outcomes of CTO PCIs in patients with and without OSAS in a multicenter registry.

Results: Of 7403 patients who underwent 7408 CTO PCIs between 2012 and 2024 at 47 centers, 942 (13%) had OSAS.

Comparison of Alcohol Septal Ablation With Mavacamten in Obstructive Hypertrophic Cardiomyopathy.

Obstructive hypertrophic cardiomyopathy (HCM) is associated with significant morbidity attributed to left ventricular outflow tract (LVOT) obstruction. Although alcohol septal ablation (ASA) is an established interventional treatment, mavacamten, a novel cardiac myosin inhibitor, has emerged as a noninvasive pharmacologic alternative. Understanding the comparative efficacy of these 2 treatments is important for optimizing patient care.

Managing Left Ventricular Outflow Tract Obstruction in Combined Aortic Stenosis and Hypertrophic Cardiomyopathy.

This study presents an elderly man with sequential hemodynamic obstructions caused by hypertrophic cardiomyopathy and aortic stenosis. Septal reduction therapy was performed to avoid outflow tract obstruction associated with potential future transcatheter aortic valve replacement. This case highlights the importance of resolving outflow tract obstruction during assessment of aortic valve disease.

Retraction notice to "E-39 | Association Between Sodium-Glucose Co-Transporter 2 Inhibitor Use and 30-Day Outcomes after Transcatheter Aortic Valve Replacement: A Retrospective Matched Cohort Analysis" [JSCAI 3 (2024) 101800].

[This retracts the article DOI: 10.1016/j.jscai.

Age-Stratified Surgical Aortic Valve Replacement for Aortic Stenosis.

Background: The management of aortic stenosis has evolved to stratification by age as reflected in recent societal guidelines. We evaluated age-stratified surgical aortic valve replacement (SAVR) trends and outcomes in patients with bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) from The Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Methods: This cohort included adults (≥18 years) undergoing SAVR for severe aortic stenosis between July 2011 and December 2022.

Echocardiographic parameters associated with less reverse left ventricular remodeling after transcatheter aortic valve implant in subjects with prosthesis patient mismatch.

Background: Transaortic valve implant (TAVI) is the treatment of choice for severe aortic stenosis (AS). Some patients develop prosthesis patient mismatch (PPM) after TAVI. It is challenging to determine which patients are at risk for clinical deterioration.

Percutaneous coronary intervention for ventricular fibrillation in the setting of an anomalous right coronary artery.

We present a case of a quadriplegic male who developed ventricular fibrillation associated with an anomalous aortic origin of the right coronary artery. Successful revascularization was achieved with percutaneous coronary intervention. This case highlights the application of an unconventional approach to resolve ischemia in a patient with prohibitive surgical risk.

Case report: Multimodality imaging of unusual coronary to pulmonary collaterals in chronic thromboembolic pulmonary hypertension.

We present unusual coronary-pulmonary collaterals in a 65-year-old CTEPH patient. Perfusion mapping of a dual-energy computed tomography (DECT) study revealed areas of right lung that were minimally perfused despite unilateral occlusion of the right pulmonary artery, leading to the discovery of coronary-pulmonary collaterals invasive coronary angiography. Pulmonary thromboendarterectomy removed the clot en-bloc.

Race-Specific Impact of Conventional Surgical Risk Score on 1-Year Mortality After Transcatheter Aortic Valve Replacement.

Background: Interracial differences in the distribution and prognostic value of conventional Society of Thoracic Surgeons (STS) score on long-term mortality after transcatheter aortic valve replacement (TAVR) are uncertain.

Objectives: This study aims to compare the impact of STS scores on clinical outcomes at 1-year after TAVR between Asian and non-Asian populations.

Methods: We used the Trans-Pacific TAVR (TP-TAVR) registry, a multinational multicenter, observational registry involving patients undergoing TAVR at 2 major centers in the United States and 1 major center in Korea.

Use of Mechanical Circulatory Support in Chronic Total Occlusion Percutaneous Coronary Intervention.

The use of mechanical circulatory support (MCS) in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study. We analyzed the clinical and angiographic characteristics, and procedural outcomes of 7,171 CTO PCIs performed between 2012 and 2021 at 35 international centers. Mean age was 64.