Time-varying impact of established prognostic factors in resected pancreatic ductal adenocarcinoma.

Background: Prognostic factors in resected pancreatic ductal adenocarcinoma (PDAC) have been determined under the assumption that hazard ratios (HRs) remain static. However, PDAC is a dynamic disease with evolving conditional survival. The aim of this study was to determine if the impact of prognostic factors in PDAC is time-varying.

Surgical Complications in Patients with (borderline) Resectable Pancreatic Cancer after Neoadjuvant Therapy in the PREOPANC-2 Randomized Controlled Trial.

Objective: To compare the incidence of major surgical complications between patients with (borderline) resectable pancreatic cancer treated with neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy.

Summary Of Background Data: There are ongoing concerns regarding the possible adverse impact of neoadjuvant treatment on postoperative complication rates following pancreatectomy.

Methods: This study was a predefined analysis within the investigator-initiated nationwide randomized controlled PREOPANC-2 trial.

Cost-effectiveness of [F]FDG PET/CT in follow-up after thermal ablation in patients with colorectal liver metastases in the Dutch healthcare setting.

Introduction: The ESMO and ECIO-ESOI consensus guidelines vary in their recommendations regarding the use of F-Fluorodeoxyglucose ([F]FDG) PET/CT in the follow-up after thermal ablation in patients with colorectal liver metastases. This is partly because studies providing data on long-term benefits of [F]FDG PET/CT are lacking. Therefore, a simulation model was developed to examine how follow-up with [F]FDG PET/CT impacts treatment planning, health and cost outcomes.

A transcriptomic analysis of ethephon-induced sex reversion of male Cannabis sativa L. reveals changes in expression of floral homeotic genes and a distinct trichome morphology.

Cannabis sativa is a dioecious crop whose agricultural productivity is linked to its sex expression. In a medicinal context, only female flowers produce an abundance of glandular trichomes responsible for producing valuable cannabinoids. Thus, understanding sex-determining factors is vital in Cannabis sativa crop improvement for specific end uses.