Publications by authors named "Isabel Parees"
Background: Monitoring motor symptoms in patients with Parkinson disease (PD) presents significant challenges due to the complex nature of symptom progression, variations in medication responses, and the fluctuations that can occur throughout the day. Traditional neurological visits provide only a limited perspective of a patient's overall condition, with challenges in achieving accurate and objective assessments of symptoms. To bridge this gap, extended monitoring in nonclinical settings could play a critical role in personalizing treatments and improving their efficacy.
View Article and Find Full Text PDFBackground: Parkinson’s Disease (PD)-associated subjective cognitive decline (PDSCD) is defined as cognitive complaints without objective cognitive impairment. Based on most studies, it is associated with a greater risk of cognitive decline and may represent a prodromal stage of cognitive impairment.
Methods: The main objectives are to identify cognitive progression patterns and clinical predictors of worse cognitive decline within a large PD-SCD cohort with a 4-year followup.
Background And Objective: Dysphagia at time of diagnosis suggests atypical parkinsonism instead Parkinson´s disease (PD). Our aim was to analyze the frequency of dysphagia in patients with early PD comparing with a control group and to identify related factors.
Patients And Methods: Patients with early PD (≤ 2 years from symptoms onset) who were recruited from January/2016 to November/2017 (baseline visit; V0) and evaluated annually for 5 years from the Spanish cohort COPPADIS were included in this prospective study.
Article Synopsis
- Functional neurological disorder (FND) is a significant cause of neurological disability in Europe, but it receives inadequate attention in medical training compared to conditions like multiple sclerosis (MS).
- A survey of 25 countries revealed that FND is often not included in mandatory neurology training and has limited representation in examinations and specialized services.
- There is a notable disparity in access to care and disability benefits for FND patients, highlighting the need for improvements in education, healthcare policies, and patient advocacy.
Article Synopsis
- The study aimed to investigate the relationship between headaches and functional movement disorders by examining the prevalence and characteristics of headaches in patients with these conditions.* -
- Out of 51 patients, 78% reported recurrent headaches, with high intensity and significant impact on daily life, particularly noting that 70% experienced headaches before the onset of their movement disorders.* -
- Headaches were predominantly classified as migraines or probable migraines (58%), followed by tension-type headaches (27%), highlighting the need for better understanding and treatment options for headache in this patient population.*
Background: Levodopa-induced dyskinesias (LID) are frequent in Parkinson's disease (PD).
Objective: To analyze the change in the frequency of LID over time, identify LID related factors, and characterize how LID impact on patients' quality of life (QoL).
Patients And Methods: PD patients from the 5-year follow-up COPPADIS cohort were included.
Revisiting the jumping to conclusions bias in functional movement disorders.
J Neurol Neurosurg Psychiatry
August 2024
Functional comorbidity in Parkinson disease: A window of opportunity.
Parkinsonism Relat Disord
January 2024
Article Synopsis
- Functional neurological disorder (FND) is a common and serious condition that many doctors don’t fully understand.
- It has been recognized for over 100 years but people with FND still face unfair treatment and discrimination.
- The text argues that FND is a feminist issue because it often affects women and highlights the need for better education and healthcare for those affected by this disorder.
Functional neurological disorders after COVID-19 and SARS-CoV-2 vaccines: a national multicentre observational study.
J Neurol Neurosurg Psychiatry
September 2023
Article Synopsis
- Dopamine replacement therapy is crucial for managing motor and nonmotor symptoms in Parkinson's disease, but treatment adjustments become necessary as the disease progresses.
- The study aimed to validate the OPTIMIPARK questionnaire, which assesses patient symptoms, to aid clinicians in making treatment decisions for those on levodopa.
- Results showed that the OPTIMIPARK score led to more patients needing treatment changes compared to standard evaluations, suggesting it could be a more effective tool for determining therapeutic needs in Parkinson's patients.
Article Synopsis
- Functional Neurological Disorders (FND) can often occur alongside other neurological conditions, such as Creutzfeldt-Jakob disease (CJD), and may be the first signs of these underlying diseases.
- In a study of three patients, positive signs of functional movement disorders were observed before they were diagnosed with CJD, showing symptoms like unilateral tremors and limb weakness.
- The progression of their conditions was rapid, leading to significant deterioration and death within 2-3 months, emphasizing the importance of recognizing FND for proper diagnosis and management in neurology.
Background: Impaired eyeblink conditioning is often cited as evidence for cerebellar dysfunction in isolated dystonia yet the results from individual studies are conflicting and underpowered.
Objective: To systematically examine the influence of dystonia, dystonia subtype, and clinical features over eyeblink conditioning within a statistical model which controlled for the covariates age and sex.
Methods: Original neurophysiological data from all published studies (until 2019) were shared and compared to an age- and sex-matched control group.
Background: Parkinson's disease (PD) patients, especially those on dopamine agonists (DA), are at risk of impulse control disorders (ICD). Little attention has been paid to the influence of environmental factors.
Cases: Retrospective analysis of consecutive PD patients seen in our outpatient Movement Disorders Clinic during 2 months (September-November 2020) to explore the frequency of ICD during the preceding 2-month lockdown period, and comparison with an equivalent control group (September-November 2019).
Dystonia in a Female Fragile X Premutation Carrier.
Mov Disord Clin Pract
July 2021
There is a growing interest in functional movement disorders (FMD). However, epidemiological data from large cohorts of patients with FMD are scarce and come mainly from General Neurology and Movement Disorders Clinics. Recently, specialized FMD clinics have been developed and epidemiological data from such clinics may provide useful information.
View Article and Find Full Text PDFEvidence for a Window of Enhanced Plasticity in the Human Motor Cortex Following Ischemic Stroke.
Neurorehabil Neural Repair
April 2021
Article Synopsis
- The study aimed to investigate changes in synaptic plasticity in the human brain after ischemic stroke, focusing on the potential for enhanced recovery during early post-stroke weeks and months.
- Researchers used continuous theta burst stimulation (cTBS) on the motor cortex of stroke survivors to measure synaptic plasticity by assessing changes in cortical excitability and motor-evoked potentials.
- Findings indicated that cTBS effects were most significant shortly after the stroke in the contralesional hemisphere, suggesting that this period may be optimal for behavioral training to improve recovery outcomes.
Functional movement disorder comorbidity in Parkinson's disease: Unraveling the web.
Parkinsonism Relat Disord
January 2021
Functional movement disorders are commonly seen in neurology services and may coexist with other neurological diseases. This combination is known as "functional overlay" and an increasing interest on this topic has emerged in the past decade as the field of functional neurological disorders has moved forward. Some neurological diseases may be more prone to develop "functional overlay" than others, and within the field of movement disorders, most studies have focused on patients with Parkinson's disease.
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