Keyword-optimized template insertion for clinical note classification via prompt-based learning.

Background: Prompt-based learning involves the additions of prompts (i.e., templates) to the input of pre-trained large language models (PLMs) to adapt them to specific tasks with minimal training.

Characterization and clustering of intra-day physical activity patterns using accelerometry among sexual and gender minority adults.

Background: Sexual and gender minority (SGM) adults experience significant health disparities linked to chronic exposure to minority stressors (e.g., discrimination), and could be reciprocally associated with physical activity (PA) behavior.

Wearable Devices Identify Altered Sleep Characteristics and Sleep Trajectories in Active Inflammatory Bowel Disease.

Background And Aims: Poor sleep is associated with flares of inflammatory bowel disease (IBD). Studies often rely on subjective assessments of sleep and disease activity. Our aim is to use wearable devices to objectively assess the impact of inflammation and symptoms on sleep architecture in IBD.

Sexual identity differences in ideal cardiovascular health among cisgender adults in the All of Us Research Program.

Background: Cardiovascular health (CVH) disparities have been documented among sexual minority adults, yet prior research has focused on individual CVH metrics. We sought to examine sexual identity differences in CVH using the American Heart Association's composite measure of ideal CVH, which provides a more comprehensive assessment of future CVD risk.

Methods: Data from the All of Us Research Program were analyzed.

Trajectories of mHealth-Tracked Mental Health and Their Predictors in Female Chronic Pelvic Pain Disorders.

Background: Female chronic pelvic pain disorders (CPPDs) affect 1 in 7 women worldwide and are characterized by psychosocial comorbidities, including a reduced quality of life and 2-10-fold increased risk of depression and anxiety. Despite its prevalence and morbidity, CPPDs are often inadequately managed with few patients experiencing relief from any medical intervention. Characterizing mental health symptom trajectories and lifestyle predictors of mental health is a starting point for enhancing patient self-efficacy in managing symptoms.

Self-reported and tracker-estimated physical activity outcomes in women with chronic pelvic pain disorders: A longitudinal evaluation of construct validity.

Objective: This study aims to evaluate the short form International Physical Activity Questionnaire (IPAQ) for use in women with chronic pelvic pain disorders (CPPDs) by comparing its scores against objectively-estimated physical activity (PA) outcomes. We investigated IPAQ components that are most consistently predictive of habitual PA behavior.

Method: The study sample included 966 weeks of data from 112 women with CPPDs who enrolled in a 14-week mHealth-based self-tracking study.

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study.

Background: Provoked anger is associated with an increased risk of cardiovascular disease events. The underlying mechanism linking provoked anger as well as other core negative emotions including anxiety and sadness to cardiovascular disease remain unknown. The study objective was to examine the acute effects of provoked anger, and secondarily, anxiety and sadness on endothelial cell health.

Development of the ehive Digital Health App: Protocol for a Centralized Research Platform.

Background: The increasing use of smartphones, wearables, and connected devices has enabled the increasing application of digital technologies for research. Remote digital study platforms comprise a patient-interfacing digital application that enables multimodal data collection from a mobile app and connected sources. They offer an opportunity to recruit at scale, acquire data longitudinally at a high frequency, and engage study participants at any time of the day in any place.

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose-Response Analysis of a Randomized Crossover Trial.

Purpose: Sedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Physical activity guidelines recommend reductions in sedentary time; however, quantitative guidelines that inform how often and how long sedentary time should be interrupted have not been provided. The purpose of this study was to examine the acute effects of multiple doses of a sedentary break intervention on cardiometabolic risk factors, concurrently evaluating efficacy of varying frequencies and durations of sedentary breaks.

An interactive fitness-for-use data completeness tool to assess activity tracker data.

Objective: To design and evaluate an interactive data quality (DQ) characterization tool focused on fitness-for-use completeness measures to support researchers' assessment of a dataset.

Materials And Methods: Design requirements were identified through a conceptual framework on DQ, literature review, and interviews. The prototype of the tool was developed based on the requirements gathered and was further refined by domain experts.

Associations between physical exercise patterns and pain symptoms in individuals with endometriosis: a cross-sectional mHealth-based investigation.

Objectives: This study investigates the association of daily physical exercise with pain symptoms in endometriosis. We also examined whether an individual's typical weekly (ie, habitual) exercise frequency influences (ie, moderates) the relationship between their pain symptoms on a given day (day ) and previous-day (day ) exercise.

Participants: The sample included 90 382 days of data from 1009 participants (~85% non-Hispanic white) living with endometriosis across 38 countries.

Associations Between Habitual Sedentary Behavior and Endothelial Cell Health.

Unlabelled: Endothelial dysfunction is a mechanism that may explain the link between prolonged sedentary time and cardiovascular disease. However, the relation between habitual sedentary behavior (SED) and endothelial function has yet to be explored.

Purpose-: The purpose of this study was to examine the association of accelerometer-measured SED with markers of endothelial cell health.

Factors Affecting the Quality of Person-Generated Wearable Device Data and Associated Challenges: Rapid Systematic Review.

Background: There is increasing interest in reusing person-generated wearable device data for research purposes, which raises concerns about data quality. However, the amount of literature on data quality challenges, specifically those for person-generated wearable device data, is sparse.

Objective: This study aims to systematically review the literature on factors affecting the quality of person-generated wearable device data and their associated intrinsic data quality challenges for research.

Augmenting the Clinical Data Sources for Enigmatic Diseases: A Cross-Sectional Study of Self-Tracking Data and Clinical Documentation in Endometriosis.

Background: Self-tracking through mobile health technology can augment the electronic health record (EHR) as an additional data source by providing direct patient input. This can be particularly useful in the context of enigmatic diseases and further promote patient engagement.

Objectives: This study aimed to investigate the additional information that can be gained through direct patient input on poorly understood diseases, beyond what is already documented in the EHR.

Anxiety Sensitivity and Physical Inactivity in a National Sample of Adults with a History of Myocardial Infarction.

Background: The psychological factors underlying physical inactivity in vulnerable cardiac adult populations remain understudied. Anxiety sensitivity, a cognitive vulnerability defined as fear of the physical, cognitive, and social consequences of anxiety, may be an important modifiable determinant of physical inactivity. We examined the association of anxiety sensitivity, and each anxiety sensitivity subscale (physical, cognitive, and social concerns), with physical inactivity in adults with a history of myocardial infarction (MI).

Testing the cross-stressor hypothesis under real-world conditions: exercise as a moderator of the association between momentary anxiety and cardiovascular responses.

The cross-stressor adaptation hypothesis of exercise training has not been investigated under real-life conditions. Using ecological momentary assessment, we tested whether usual exercise level moderates the relationship of self-reported anxiety to concurrent ambulatory heart rate (HR) and systolic/diastolic blood pressure (SBP/DBP). Participants (N = 832) completed 24-h ambulatory monitoring of HR/BP, using a brachial BP cuff that took readings at 28-min intervals.

The effects of acute yoga on anxiety symptoms in response to a carbon dioxide inhalation task in women.

Purpose: We investigated the efficacy of yoga for improving cognitive and physical anxiety symptoms, and its possible respiratory mechanism, in high-anxious women.

Methods: Eighteen participants completed 40 min of guided yoga and a light stretching protocol in a randomized, counterbalanced order.The 7.

Quantile Coarsening Analysis of High-Volume Wearable Activity Data in a Longitudinal Observational Study.

Owing to advances in sensor technologies on wearable devices, it is feasible to measure physical activity of an individual continuously over a long period. These devices afford opportunities to understand individual behaviors, which may then provide a basis for tailored behavior interventions. The large volume of data however poses challenges in data management and analysis.

Putative mechanisms Underlying Myocardial infarction onset and Emotions (PUME): a randomised controlled study protocol.

Introduction: The experience of negative emotions (eg, anger, anxiety and sadness) is associated with an increased short-term risk of incident cardiovascular disease (CVD) events, independent of traditional CVD risk factors. Impairment in endothelial function is one possible biological mechanism which may explain the association between negative emotions and incident CVD events. This laboratory-based, single-blind, randomised controlled experimental study aims to investigate the impact of induced negative emotions including anger, anxiety and sadness on endothelial function.

The Influence of Daily Stress on Sedentary Behavior: Group and Person (N of 1) Level Results of a 1-Year Observational Study.

Objective: The purpose of this study, which used mobile technologies to continuously collect data for 1 year, was to examine the association of psychological stress with objectively measured sedentary behavior in adults at both the group (e.g., nomothetic approach) and individual (e.

Do depressive symptoms influence cognitive-motor coupling in multiple sclerosis?

Objective: There is evidence that motor and cognitive impairments often co-occur in multiple sclerosis (MS). There is little research on influences of cognitive-motor coupling, particularly depressive symptoms. This study examined depressive symptoms as a moderator and/or confounder of cognitive-motor coupling in persons with MS.