Ivermecatin induces cytotoxic effects in SUP-B15 cell line.

Background: Glucocorticoids remain the primary treatment for acute lymphoblastic leukemia (ALL) in children. However, glucocorticoid-resistant ALL exhibits increased mortality rates. To overcome resistance and improve management strategies, alternative therapeutic agents are required.

Knowledge, attitude, and practice of neurologists toward primary progressive aphasia in Indonesia.

BackgroundPrimary progressive aphasia (PPA) is a neurodegenerative syndrome that impairs language and speech abilities. Limited research exists on PPA in Indonesia, and understanding neurologists' perspectives is crucial for improving early diagnosis and management.ObjectiveThis study aimed to assess Indonesian neurologists' knowledge, attitudes, and practices regarding PPA.

Serology reveals comparable patterns in the transmission intensities of and in Langkat district, North Sumatera Province, Indonesia.

Introduction: The incidence of malaria in Indonesia has declined significantly over the last few decades. Thus, a demand for more sensitive techniques to describe low levels of transmission in the country is important. This study was conducted to evaluate antibody response to and in an area nearing elimination in North Sumatera Province, Indonesia.

Improved limit of detection for zoonotic Plasmodium knowlesi and P. cynomolgi surveillance using reverse transcription for total nucleic acid preserved samples or dried blood spots.

Background: Zoonotic P. knowlesi and P. cynomolgi symptomatic and asymptomatic infections occur across endemic areas of Southeast Asia.

A new focus of Taenia asiatica taeniasis in North Sumatra, Indonesia: Molecular confirmation and prevalence.

In the Samosir Island of North Sumatra, Indonesia, the prevalence of taeniasis caused by Taenia asiatica was reported as 2.2 %-20.7 % during 1972-2005.

The Use of Platelet Count and Indices as Prognostic Factors for Mortality in Children with Sepsis.

Background: Sepsis is still one of the leading causes of mortality and morbidity in children worldwide. Consumptive coagulopathy and suppression of thrombopoiesis in the bone marrow resulting from immune dysregulation are pathological mechanisms that cause thrombocytopenia in sepsis. Platelet count (PLT) and indices, such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) are markers of platelet activation and are strongly influenced by platelet morphology and proliferation kinetics.

Community Actions and Insights in the Battle against COVID-19 at the Start of the Pandemic: A District Study Observation from Medan, Indonesia.

Background: As of 17 June 2020, the WHO confirmed 8,061,550 COVID-19 cases globally, with Indonesia reporting 40,400 cases and North Sumatra over 932 cases. The rising infection rates have led to increased deaths, highlighting the urgency for public understanding of virus transmission. Despite information dissemination efforts, North Sumatra has not seen a reduction in cases, emphasizing the need for a unified approach to combat the pandemic.

Updating estimates of Plasmodium knowlesi malaria risk in response to changing land use patterns across Southeast Asia.

Background: Plasmodium knowlesi is a zoonotic parasite that causes malaria in humans. The pathogen has a natural host reservoir in certain macaque species and is transmitted to humans via mosquitoes of the Anopheles Leucosphyrus Group. The risk of human P.

A multi-criteria framework for disease surveillance site selection: case study for malaria in Indonesia.

Disease surveillance aims to collect data at different times or locations, to assist public health authorities to respond appropriately. Surveillance of the simian malaria parasite, , is sparse in some endemic areas and the spatial extent of transmission is uncertain. Zoonotic transmission of has been demonstrated throughout Southeast Asia and represents a major hurdle to regional malaria elimination efforts.

SARS-CoV-2 lineages circulating during the first wave of the pandemic in North Sumatra, Indonesia.

Objectives: To determine the lineage distribution of the virus during the first wave of the pandemic in North Sumatra, Indonesia.

Methods: A total of 20 samples with positive results based on reverse transcription-polymerase chain reaction were selected for virus culture and then performed whole-genome sequence analysis using next-generation sequencing which was applied by the Illumina MiSeq instrument.

Results: Whole-genome sequence analysis revealed that the majority of our samples belong to lineages B.

Evidence of Submicroscopic Plasmodium knowlesi Mono-Infection in Remote Indigenous Communities in Kelantan, Peninsular Malaysia.

Malaysia has maintained zero cases of indigenous human malaria since 2018. However, zoonotic malaria is still prevalent in underdeveloped areas and hard-to-reach populations. This study aimed to determine the prevalence of malaria among remote indigenous communities in Peninsular Malaysia.

Mothers' knowledge, attitude, and behavior regarding child immunization, and the association with child immunization status in Medan City during the COVID-19 pandemic.

Background: The COVID-19 pandemic has caused disruption to healthcare access worldwide and has impacted basic childhood immunization services. A decline in immunization coverage can cause immunity gaps and lead to outbreaks of vaccine-preventable diseases. Our study evaluated the association between mothers' knowledge, attitude, and behavior regarding immunization and child immunization status during the COVID-19 pandemic in Medan, Indonesia.

Use of saliva as an alternative diagnostic method for diagnosis of COVID-19.

Background: Mass population testing has been recommended to contain the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, the use of nasopharyngeal swab specimens has caused many logistic challenges. This study investigated the sensitivity and specificity of saliva as a non-invasively-obtained specimen for molecular detection of SARS-CoV-2 RNA.

Sensitivity of nasopharyngeal swab and saliva specimens in the detection of SARS-CoV-2 virus among boarding school girls.

Objectives: With the reopening of schools, the detection of coronavirus disease 2019 (COVID-19) in children is very important in order to prevent outbreaks in schools and to reduce the risk of more severe post-COVID-19 complications. Various specimens can be used to detect the SARS-CoV-2 virus, and saliva has been considered as an alternative specimen in adults. However, data in children are lacking, especially among the female population.

The trend of paediatric cases during the first year of the COVID-19 pandemic in North Sumatra, Indonesia.

Objective: The aim of the study was to describe the epidemiology of coronavirus disease 2019 (COVID-19) cases in children in North Sumatra Province during the period June 2020 to July 2021.

Methods: This study included samples from children in North Sumatra Province aged 0-17 years, suspected to have COVID-19. A case of COVID-19 was confirmed by RT-PCR in the Microbiology Laboratory, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.

The presence of Plasmodium malariae and Plasmodium knowlesi in near malaria elimination setting in western Indonesia.

Background: Indonesia is progressing towards malaria elimination. To achieve this goal, intervention measures must be addressed to cover all Plasmodium species. Comprehensive control measures and surveillance programmes must be intensified.

Seroepidemiological surveillance, community perceptions and associated risk factors of malaria exposure among forest-goers in Northeastern Thailand.

Malaria remains a major public health challenge in Thailand. Continuous assessment and understanding of the behavior and perceptions related to malaria exposure in the high-risk group are necessary to achieve the elimination goal. This study aimed to investigate the parasite prevalence, seroprevalence rate, knowledge, attitudes, and practices (KAP), and malaria risk factors in rural communities living close to a forested area in the northeastern part of Thailand.

Clinical Epidemiology of Pediatric COVID-19 Delta Variant Cases From North Sumatra, Indonesia.

The Delta variant of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) dominated the coronavirus disease 2019 (COVID-19) pandemic in 2021. Here we report the Delta variant among pediatric cases in North Sumatra, Indonesia, from June to July 2021. Whole-genome sequencing (WGS) from 18 new COVID-19 pediatric patients showed that six were B.

Perceptions and prevention practices on malaria among the indigenous Orang Asli community in Kelantan, Peninsular Malaysia.

Background: Malaysia is on track towards malaria elimination. However, several cases of malaria still occur in the country. Contributing factors and communal aspects have noteworthy effects on any malaria elimination activities.

Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?

Rapid diagnostic tests (RDTs) play a critical role in malaria diagnosis and control. The emergence of parasites that can evade detection by RDTs threatens control and elimination efforts. These parasites lack or have altered genes encoding histidine-rich proteins (HRPs) 2 and 3, the antigens recognized by HRP2-based RDTs.

Recurrence of and Following Treatment of Uncomplicated Malaria in North Sumatera With Dihydroartemisinin-Piperaquine or Artemether-Lumefantrine.

Background: We assessed the efficacy of artemisinin-based combination therapies for treatment of uncomplicated malaria, with or without co-infecting spp., in Sumatera, Indonesia.

Methods: Febrile patients aged >6 months with uncomplicated were randomized to receive dihydroartemisinin-piperaquine or artemether-lumefantrine, plus single-dose primaquine, and were followed for 42 days.