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Background: Indonesia is progressing towards malaria elimination. To achieve this goal, intervention measures must be addressed to cover all Plasmodium species. Comprehensive control measures and surveillance programmes must be intensified. This study aims to determine the prevalence of microscopic and submicroscopic malaria in Langkat district, North Sumatera Province, Indonesia.
Methods: A cross-sectional survey was conducted in six villages in Langkat district, North Sumatera Province in June 2019. Data were recorded using a standardized questionnaire. Finger pricked blood samples were obtained for malaria examination using rapid diagnostic test, thick and thin blood smears, and polymerase chain reaction.
Results: A total of 342 individuals were included in the study. Of them, one (0.3%) had a microscopic Plasmodium malariae infection, no positive RDT examination, and three (0.9%) were positive for P. malariae (n = 1) and Plasmodium knowlesi (n = 2). The distribution of bed net ownership was owned by 40% of the study participants. The participants had a house within a radius of 100-500 m from the forest (86.3%) and had the housing material of cement floor (56.1%), a tin roof (82.2%), wooden wall (35.7%), bamboo wall (28.1%), and brick wall (21.6%).
Conclusion: Malaria incidence has substantially decreased in Langkat, North Sumatera, Indonesia. However, submicroscopic infection remains in the population and may contribute to further transmission. Surveillance should include the detection of microscopic undetected parasites, to enable the achievement of malaria elimination.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636705 | PMC |
http://dx.doi.org/10.1186/s12936-022-04335-y | DOI Listing |
Commun Med (Lond)
September 2025
Department of Microbiology and Immunology, Bio21 Institute and The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Background: Mixed-species, mixed-strain plasmodia infections are known to occur in humans in malaria endemic areas. It may be surprising that to date, the extent of this complexity has not been systematically explored in high-burden countries of sub-Saharan Africa, especially in the reservoir of asymptomatic infections in all ages, which sustains transmission.
Methods: Here we take a metagenomic lens to these infections by sampling variable blood volumes from 188 afebrile residents living in high, seasonal transmission in Northern Sahelian Ghana.
Vet World
July 2025
Department of Plant Protection, Faculty of Agriculture, Universitas Sriwijaya, 30662 Indralaya, Indonesia.
Background And Aim: Zoonotic malaria remains a significant public health concern in Southeast Asia. The potential role of cattle as reservoirs for spp. in Indonesia has not been fully elucidated, despite increasing recognition of animal reservoirs in malaria transmission dynamics.
View Article and Find Full Text PDFBJOG
September 2025
Department of Behavioral and Community Health Sciences, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Objective: This study explores the relationship between pregnancy intentions and maternal health behaviours.
Design And Setting: Secondary data analysis of recent (2018-2023), cross-sectional demographic and health surveys from 18 sub-Saharan African countries.
Population: Survey respondents were women aged 15-49 years old with a child less than a year old who responded to survey questions about their pregnancy intentions for that child (N = 39 936).
Afr J Prim Health Care Fam Med
August 2025
Department of Health Studies, College of Human Science, University of South Africa, Pretoria, South Africa; and Department of Public Health, School of Health Science, Shashemene Campus, Madda Walabu University, Shashemene.
Background: Malaria is a leading cause of morbidity, mortality and socio-economic burden in Ethiopia. Although the country set a goal to eradicate malaria by 2030, a resurgence has been reported recently.
Aim: This study was conducted to assess the signs of malaria, its symptoms and knowledge regarding prevention and its associated factors among rural Ethiopians.
J Med Chem
September 2025
Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
New treatment strategies are required to combat the spread of drug-resistant malaria. The synthesis and preclinical evaluation of novel 3-hydroxy-propanamidines (HPAs), with modifications of the phenanthrene and the 4-fluorobenzamidine moieties, has yielded several analogs exhibiting excellent in vitro growth inhibition of drug-sensitive or resistant fresh clinical isolates and culture-adapted strains. No cytotoxicity in the human HepG2 cell line was observed, demonstrating notable parasite selectivity.
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