Slow nocturnal body cooling during sleep increases interbeat intervals and is tightly coupled to high-frequency heart rate variability in healthy men.

During nocturnal sleep, core body temperature (CBT) decreases and cardiac inter-beat intervals (IBI) increase. This study used a non-disturbing cooling intervention during sleep to investigate additional effects of CBT reduction on IBI and heart rate variability. Sleep on a high heat-capacity cooling gel mattress (HM) was compared to a low heat-capacity mattress (LM) in 32 healthy males (age 46 ± 4 years).

The Role of the Sleep Centre in the Future of Sleep Medicine. How Should It Be Organised? Will There Still Be Sleep Inpatients in the Future?

Sleep medicine centres play a pivotal role in diagnosing, treating and researching sleep disorders, with structures that range from large, university-based institutions to smaller, community-led clinics. These centres operate at the intersection of clinical care and academic innovation, combining personalised diagnostics and therapy with the evaluation and integration of emerging technologies. As the demand for sleep-related healthcare continues to grow, sleep centres must evolve to accommodate both increasing patient loads and rapid technological advancements.

[Can drug therapy for obstructive sleep apnea be expected after all?].

Obstructive sleep apnea (OSA) is a very common sleep disorder and is usually a chronic disease. Indications for treatment depend on the severity of the nocturnal breathing disorder; the specific symptoms, such as daytime sleepiness; and the comorbidities, which, together with the breathing disorder, constitute the risk of sleep apnea. Standard treatment is nocturnal positive airway pressure therapy or, especially for mild to moderate sleep apnea, a mandibular advancement device.

Performance of wearable finger ring trackers for diagnostic sleep measurement in the clinical context.

Ring-trackers are a growing consumer wearable category that provide a number of sleep metrics, yet their measurement accuracy remains poorly understood. Previous validation studies have mainly focused on healthy individuals, while a significant part of the potential present and future value lies in applications on non-healthy subjects. To enable applications in research and medical applications, rigorous evaluation of performance in clinical settings against the gold-standard polysomnography is needed.

The impact of childhood emotional abuse and depressive symptoms on sleep macro-architecture and cortical thickness.

Background: Adverse childhood events and especially emotional abuse (EA) is consistently associated with poor psychiatric outcomes in adulthood, with depressive symptoms being one of the most prevalent. Both EA and depression are frequently associated with poorer sleep quality and cortical structural abnormalities. Interestingly, some individuals who experienced early-life EA are resilient against the development of psychiatric illness in adulthood and are believed to possess distinct neurobiology that confer more effective coping mechanisms.

Association Between Sleep Position, Obesity, and Obstructive Sleep Apnea Severity.

Background: This study examines the relationship between obstructive sleep apnea severity, sleep position, and body weight, particularly focusing on the negative impact of sleeping in a supine position combined with being overweight in a population-based sample.

Methods: The Apnea-Hypopnea Index (AHI) was utilized as a marker of OSA severity and sleep position from a standardized overnight polysomnography. Participants were categorized by body mass index (BMI) (kg/m) into normal weight/underweight (<25) and overweight (≥25).

Chronic pain management and sleep disorders.

Chronic pain affects the quality of life for millions of people worldwide. There is a bidirectional link between pain and sleep: poor sleep quality exacerbates pain, and pain disrupts sleep. Addressing this cycle is crucial for effective pain management and improving patients' overall health outcomes.

Effects of Mask Change/Renewal on Adherence to Positive Airway Pressure Therapy: Analysis of a Large Telemedicine Database.

Adherence to positive airway pressure (PAP) therapy is a common and challenging issue. Although some studies have looked at the impact of initial mask selection, there is a lack of data regarding the impact of a change in mask on adherence to PAP therapy. This study investigated the impact of a mask change or renewal on midterm PAP adherence.

Effect of graduated drug therapy for moderate-to-severe chronic insomnia on the severity of disease: an observational study in Germany.

Study Objectives: Severe chronic insomnia is a common sleep disorder that is mostly persistent and needs to be treated. Pharmacologic treatment options and guidelines are sparse, particularly for long-term treatment. Our study aimed to investigate a graduated therapy scheme for moderate-to-severe chronic insomnia in practice, considering the effects on self-reported sleep quality and quality of life.

Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity.

Background: Obstructive sleep apnea is characterized by disordered breathing during sleep and is associated with major cardiovascular complications; excess adiposity is an etiologic risk factor. Tirzepatide may be a potential treatment.

Methods: We conducted two phase 3, double-blind, randomized, controlled trials involving adults with moderate-to-severe obstructive sleep apnea and obesity.

European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children.

Sleeping problems are prevalent among children and adolescents, often leading to frequent consultations with pediatricians. While cognitive-behavioral therapy has shown effectiveness, especially in the short term, there is a lack of globally endorsed guidelines for the use of pharmaceuticals or over-the-counter remedies in managing sleep onset insomnia. An expert panel of pediatric sleep specialists and chronobiologists met in October 2023 to develop practical recommendations for pediatricians on the management of sleep onset insomnia in typically developing children.

Tirzepatide for the treatment of obstructive sleep apnea: Rationale, design, and sample baseline characteristics of the SURMOUNT -OSA phase 3 trial.

Background: Weight reduction is a standard recommendation for obstructive sleep apnea (OSA) treatment in people with obesity or overweight; however, weight loss can be challenging to achieve and maintain without bariatric surgery. Currently, no approved anti-obesity medication has demonstrated effectiveness in OSA management. This study is evaluating the efficacy and safety of tirzepatide for treatment of moderate to severe OSA in people with obesity.

Positive airway pressure telehealth models and long-term therapy termination: a healthcare database analysis.

Background: Telemonitoring-guided interventions can improve short-term positive airway pressure (PAP) therapy adherence, but long-term effects are unknown. This study investigated long-term PAP therapy termination in patients with sleep apnoea managed with standard care, telemonitoring-guided proactive care or telemonitoring-guided proactive care + patient engagement tool.

Methods: German healthcare provider data were analysed retrospectively.

Enhanced conductive body heat loss during sleep increases slow-wave sleep and calms the heart.

Substantial evidence suggests that the circadian decline of core body temperature (CBT) triggers the initiation of human sleep, with CBT continuing to decrease during sleep. Although the connection between habitual sleep and CBT patterns is established, the impact of external body cooling on sleep remains poorly understood. The main aim of the present study is to show whether a decline in body temperatures during sleep can be related to an increase in slow wave sleep (N3).

Childhood maltreatment and sleep apnea: Findings from a cross-sectional general population study.

Objective: Cumulative evidence indicates that childhood maltreatment (CM) is associated with sleep disturbances possibly suggesting sleep apnea. However, the relation between CM and objective measures of sleep apnea as determined by polysomnography (PSG) has not yet been assessed.

Methods: Using a cross-sectional design and based on PSG measurements from N = 962 subjects from the SHIP-Trend general population study, we used linear regression models to investigate the relationship between apnea-hypopnea (AHI) and oxygen desaturation index (ODI) and Epworth sleepiness scale (ESS) metrics and the Childhood Trauma Questionnaire (CTQ).

Bed partner perception of CPAP therapy on relationship satisfaction and intimacy-A European perspective from the ESADA network.

Obstructive sleep apnea increases morbidity and mortality risks. The most common treatment is continuous positive airway pressure, with nasal mask usage being important, but not always optimal. While most research on treatment adherence focuses on the patient, the bed partner's involvement may be detrimental.

Clinical Applicability of Ultrasound Shear Wave Elastography in Patients under Hypoglossal Nerve Stimulation Therapy.

Unlabelled: Relationship between stiffness of genioglossi (GG) and geniohyoidei (GH) muscles under electric hypoglossal nerve stimulation therapy (HNS) in relation to success of therapy was investigated with additional special focus on tongue movement.

Patients And Methods: Clinical and sleep laboratory parameters of a cohort of 18 patients with known shear wave velocity (SWV) data of the ipsilateral and contralateral musculi GG and GH (sGG, sGH and nGG, nGH) before and under HNS therapy were analyzed. The SWV was already determined using the ultrasonic shear wave elastography (US-SWE) technique.

Polysomnographic characteristics of sleep in adults with and without physician-diagnosed atopic dermatitis: results from the Study of Health in Pomerania.

Purpose: To analyze sleep characteristics as measured with polysomnography (PSG) in adults from the general population with and without physician-diagnosed atopic dermatitis (AD).

Methods: We analyzed data from participants from the German population-based Study of Health in Pomerania (SHIP) TREND-0. AD was diagnosed in a standardized skin examination.

Nocturnal positive pressure ventilation improves relationship satisfaction of patients with OSA and their partners.

Objective: Continuous positive airway pressure (CPAP) ventilation is considered the therapeutic standard for obstructed sleep apnea (OSA). Therapy success may also be affected by the patient's bed partner. A questionnaire was developed and tested that measures the attitude of the bed partner towards CPAP therapy and relationship effects.

Obstructive sleep apnea heterogeneity and autonomic function: a role for heart rate variability in therapy selection and efficacy monitoring.

Obstructive sleep apnea is a highly prevalent sleep-related breathing disorder, resulting in a disturbed breathing pattern, changes in blood gases, abnormal autonomic regulation, metabolic fluctuation, poor neurocognitive performance, and increased cardiovascular risk. With broad inter-individual differences recognised in risk factors, clinical symptoms, gene expression, physiological characteristics, and health outcomes, various obstructive sleep apnea subtypes have been identified. Therapeutic efficacy and its impact on outcomes, particularly for cardiovascular consequences, may also vary depending on these features in obstructive sleep apnea.

Comparative study of the SleepImage ring device and polysomnography for diagnosing obstructive sleep apnea.

Unlabelled: We aim to evaluate the diagnostic performance of the SleepImage Ring device in identifying obstructive sleep apnea (OSA) across different severity in comparison to standard polysomnography (PSG). Thirty-nine patients (mean age, 56.8 ± 15.