Efficient Ag/La-ZnO core-shell catalyst for green synthesis of 4-pyrano[2,3-] pyrazoles.

The advancement of green and efficient synthetic strategies is essential for the pursuit of environmentally sustainable organic transformations. Pyrazole derivatives, recognized for their broad pharmacological and synthetic utility, are key structural motifs in various bioactive molecules. This study reports a one-pot, four-component (aryl aldehyde, malononitrile, ethyl acetoacetate, and hydrazine hydrate) synthesis of pyrazole derivatives catalyzed by lanthanum-doped and silver-coated ZnO (Ag/La-ZnO) core-shell nanoparticles under solvent-free grinding conditions at ambient room temperature.

Synthesis, biological evaluation, and molecular docking of novel 1,3,4-substituted-thiadiazole derivatives as potential anticancer agent.

In an attempt to develop potent anti-cancer agents, a new 1,3,4-substituted-thiadiazole derivatives (8b-g), starting from 4-substituted-thiazol-2-chloroacetamides (4b-g), were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the hepatocellular carcinoma (HEPG-2), human lung carcinoma (A549), human breast carcinoma (MCF-7) and pseudo-normal human embryonic liver (L02) cancer cell lines by an MTT assay. Among all synthesized compounds, compound 8d showed the potent anti-cancer activities with GI values of 2.98, 2.

Synthesis, Biological and Molecular Docking Studies of Thiazole-Thiadiazole derivatives as potential Anti-Tuberculosis Agents.

Tuberculosis remains a global health threat, with increasing infection rates and mortality despite existing anti-TB drugs. The present work focuses on the research findings regarding the development and evaluation of thiadiazole-linked thiazole derivatives as potential anti-tuberculosis agents. We present the synthesis data and confirm the compound structures using spectroscopic techniques.