Coumarin-Triazole-Thiazole hybrids: A new avenue in Antitubercular agents.

The present work reports the design and synthesis of a series of 2-(4-(((2-oxo-2H-chromen-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-N-(thiazol-2-yl)acetamide derivatives (4a-4k), which were investigated for their potential against tubercular activities. The well-known click cycloaddition reaction of azido derivatives (3a-3k) and 4-(prop-2-yn-1-yloxy)-2H-chromen-2-one (2) in the presence of catalytic amount of CuSO in HO and DMF was employed. Notably, compounds 4c, 4d, and 4g showed the most promising results with MIC values against tuberculosis are 7.

Synthesis, biological evaluation, and molecular docking of novel 1,3,4-substituted-thiadiazole derivatives as potential anticancer agent.

In an attempt to develop potent anti-cancer agents, a new 1,3,4-substituted-thiadiazole derivatives (8b-g), starting from 4-substituted-thiazol-2-chloroacetamides (4b-g), were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the hepatocellular carcinoma (HEPG-2), human lung carcinoma (A549), human breast carcinoma (MCF-7) and pseudo-normal human embryonic liver (L02) cancer cell lines by an MTT assay. Among all synthesized compounds, compound 8d showed the potent anti-cancer activities with GI values of 2.98, 2.

Synthesis, Biological and Molecular Docking Studies of Thiazole-Thiadiazole derivatives as potential Anti-Tuberculosis Agents.

Tuberculosis remains a global health threat, with increasing infection rates and mortality despite existing anti-TB drugs. The present work focuses on the research findings regarding the development and evaluation of thiadiazole-linked thiazole derivatives as potential anti-tuberculosis agents. We present the synthesis data and confirm the compound structures using spectroscopic techniques.