Upright-Net+: Enhanced Learning of Upright Orientation for 3D Point Clouds.

Automatic 3D shape analysis is heavily influenced by the pose of input 3D models, as the continuous nature of pose space introduces complexities that usually exceed the encoding capacities of standard deep learning frameworks. To tackle this challenge, we present Upright-Net+, an enhancement of our previous model, Upright-Net, specifically developed for estimating upright orientation in 3D point clouds. Our approach is grounded in the design principle that "form ever follows function," treating the natural base of an object as a functional structure that stabilizes it in its typical pose, influenced by physical laws and geometric properties.

[ mutation-induced end-stage renal disease presenting with massive proteinuria: a family analysis and literature review].

Objectives: To summarize the clinical and genetic characteristics of end-stage renal disease caused by gene mutations.

Methods: A retrospective analysis of the clinical and genetic features of three children from a family with gene mutations was conducted, along with a literature review of hereditary kidney disease cases caused by gene mutations.

Results: The proband was an 8-year-old male presenting with nephrotic syndrome stage 4 chronic kidney disease.

Effect of continuous nursing on treatment compliance and side effect management of coronary heart disease.

Background: There are relatively few studies on continuing care of coronary heart disease (CHD), and its research value needs to be further clarified.

Aim: To investigate the effect of continuous nursing on treatment compliance and side effect management in patients with CHD.

Methods: This is a retrospective study with patients from January 2021 to 2023.

The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism.

Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis. Ribosome profiling identified upregulation of a secreted micropeptide, C4orf48 (Cf48), in mouse diabetic nephropathy.

Risk factors and renal outcomes of AKI in children with secondary steroid-resistant nephrotic syndrome.

Background: Acute kidney injury (AKI) is increasingly prevalent in children with nephrotic syndrome (NS). It is associated with adverse outcomes in NS, especially steroid-resistant nephrotic syndrome (SRNS). The incidence, risk factors and outcomes of AKI in secondary SRNS remain undefined.

Hyperuricemia is associated with the progression of IgA nephropathy in children.

Background: The objective of the study was to explore the potential biomarkers and risk factors in children with immunoglobulin A nephropathy (IgAN).

Methods: Untargeted metabolomics analysis was performed on children with IgAN before and after treatment. Subsequently, a retrospective study involving the past 15 years and a follow-up study were performed to verify the role of hyperuricemia in IgAN children.

Mitochondrial micropeptide MOXI promotes fibrotic gene transcription by translocation to the nucleus and bridging N-acetyltransferase 14 with transcription factor c-Jun.

Progressive fibrosis is a hallmark of chronic kidney disease, but we lack effective treatments to halt this destructive process. Micropeptides (peptides of no more than 100 amino acids) encoded by small open reading frames represent a new class of eukaryotic regulators. Here, we describe that the micropeptide regulator of β-oxidation (MOXI) regulates kidney fibrosis.

Dyslipidemia may be a risk factor for progression in children with IgA nephropathy.

Background: IgA nephropathy (IgAN) is often chronically progressive and commonly accompanied by dyslipidemia. However, the intrinsic relationship between dyslipidemia and IgAN remains to be elucidated. This study aimed to investigate the impact of different types of dyslipidemia on clinical and pathological characteristics in children with IgAN.

Long-Term Outcome of Secondary Steroid-Resistant Nephrotic Syndrome in Chinese Children.

Introduction: Secondary steroid-resistant nephrotic syndrome (SRNS) refers to the condition when patients with initial steroid-sensitive nephrotic syndrome develop steroid resistance in subsequent relapses. Long-term outcomes of secondary SRNS in children are uncertain.

Methods: This was a single-center retrospective study of 56 children with secondary SRNS between 2006 and 2016.

Clinicopathological Analysis of 34 Cases of Primary Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Chinese Children.

This study aimed to summarize the clinicopathological features and prognostic risk factors of primary antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in children. Clinical and prognostic data for children admitted to our center with AAV between September 2003 and September 2020 were studied retrospectively. The incidence and risk factors of end-stage renal disease (ESRD) were calculated and analyzed.

Analysis of 10 Pediatric Nephrotic Syndrome Cases With Complications of Cerebral Sinovenous Thrombosis.

To analyze the clinical characteristics of nephrotic syndrome (NS) with complications of cerebral sinovenous thrombosis (CSVT) in children. Clinical, radiographic, laboratory, and treatment data obtained from 10 confirmed cases of NS with complications of CSVT were analyzed. All patients were followed up for at least 18 months.

Anatomical variations of the aortic arch branches in a sample of Chinese cadavers: embryological basis and literature review.

Objectives: The aim of this study is to determine the incidence and explore the types of aortic arch branch variations found in our cadavers.

Methods: The types and incidence of aortic branch variations in 120 cadavers were analysed after careful dissection.

Results: One hundred and six of 120 cadavers had normal aortic arch branches and gave rise to usual branches, namely the brachiocephalic trunk, the left common carotid artery and the left subclavian artery.