Publications by authors named "HengJin Tian"
Background: Gastric cancer (GC), a prevalent aggressive form of tumor, imposes a significant burden in terms of morbidity and mortality. Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen synthesis, comprises two identical alpha subunits and two beta subunits. Studies on the expression and impact of P4HA1 in GC cells are limited.
View Article and Find Full Text PDFPGD2/PTGDR2 Signaling Affects the Stemness of Gastric Cancer Stem Cells by Regulating Autophagy.
Comb Chem High Throughput Screen
January 2025
Background: Prostaglandin D2 (PGD2) can inhibit the development of gastric cancer (GC); however, its role in the autophagic death of GC stem cells (GCSCs) remains elusive. Therefore, this study aims to evaluate the mechanisms by which PGD2 regulates the stemness in GCSCs.
Methods: In this study, HGC27-derived GCSCs were employed to knock down PGD2 receptor 2 (PTGDR2).
Background: Prostaglandin D2 (PGD2) inhibits the development of different malignant tumors; however, the underlying mechanism of inhibiting tumor development is not yet clear. This study aimed to elucidate how PGD2 inhibits the stemness of gastric cancer stem cells (GCSCs) autophagy and its underlying molecular mechanism to provide a theoretical basis for the treatment of gastric cancer.
Methods: In this study, GCSCs were enriched by serum-free incubation.
Aquaporin 5 (AQP5) has been shown to have a pro-carcinogenic effect in numerous types of malignancies. This research intends to investigate the role and the molecular mechanism of AQP5 on enriched gastric cancer stem cells (GCSCs). : Immunohistochemistry, western blot (WB), and RT-qPCR techniques were employed to identify the presence of AQP5 in gastric cancer (GC) and the neighboring paracancerous tissues.
View Article and Find Full Text PDFHuman Umbilical Cord Mesenchymal Stem Cell-derived Exosomes Induce Macrophage M2 Polarization by Antagonizing LPS-mediated Stimulation of the NF-κB and STAT3 Pathways.
Comb Chem High Throughput Screen
July 2025
Article Synopsis
- * In vitro experiments showed that treating macrophages with hucMSCs exosomes reduces inflammatory markers (like IL-6 and TNF-α) and promotes the expression of anti-inflammatory markers (like IL-10 and arginase) while enhancing macrophage migration and proliferation.
- * The findings suggest that hucMSCs exosomes can switch macrophages from an inflammatory (M1) to a more anti-inflammatory (M2) state by reducing NF-κB signaling and increasing STAT3 activity, offering a
Article Synopsis
- Prostaglandins, particularly PGE2 and PGD2, are important mediators in cancer-related inflammation and play key roles in tumor development and treatment.
- Signaling through the PGD2 receptor (PTGDR2) can inhibit cancer cell growth and enhance the effectiveness of chemotherapy, highlighting its potential in cancer therapy.
- Decreased levels of PGD2 are linked to poorer outcomes in various cancers, emphasizing the need for further research on PGD2 and its receptors as possible therapeutic targets.
PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents the Progression of Gastric Cancer.
Comb Chem High Throughput Screen
May 2024
Background: Prostaglandin D2 (PGD2) has been shown to restrict the occurrence and development of multiple cancers; nevertheless, its underlying molecular mechanism has not been fully elucidated. The present study investigated the effect of PGD2 on the biological function of the enriched gastric cancer stem cells (GCSCs), as well as its underlying molecular mechanism, to provide a theoretical basis and potential therapeutic drugs for gastric cancer (GC) treatment.
Methods: The plasma PGD2 levels were detected by Enzyme-linked immunosorbent assay (ELISA).
Objective: To explore the method and the therapeutic effect of the free anterolateral thigh myocutaneous flap with the tensor fascia lata for one-stage repair of soft tissues defects at the dorsum of hands (feets).
Method: Between Jan.2010 and Dec.