Bidirectional interaction between epithelial-mesenchymal transition and PD-1/PD-L1 expression in tongue carcinogenesis.

Objective: To investigate, through immunohistochemistry, the interaction between epithelial-mesenchymal transition (EMT) and the immune checkpoint proteins PD-1 and PD-L1 in oral tongue squamous cell carcinoma (OTSCC).

Design: The EMT status was determined based on the immunostaining of E-cadherin and N-cadherin proteins. EMT status and the immunoexpression of PD-L1 and PD-1 were analyzed semiquantitatively in 61 cases of OTSCC, and the cases were categorized into low and high expression groups for association with clinicopathological variables and overall survival (OS) and disease-free survival (DFS) rates.

Telehealth in oral medicine: Evaluation of app usability and satisfaction among public health system professionals.

ObjectiveEvaluate the usability and user satisfaction of an oral medicine application among public health professionals.MethodsA cross-sectional observational study was conducted with 101 dentists registered in the application, determined through sample size calculation. Data were collected using an online questionnaire.

Performance of a virtual assistant based on ChatGPT-4 in the diagnosis of syndromes with orofacial manifestations.

Objective: To evaluate the performance of the virtual assistant "Syndromic Diseases and Orofacial Features" (SDOF), developed based on the Generative Pre-trained Transformer 4 model, in formulating diagnostic hypotheses and recommendations for syndromes with orofacial manifestations.

Study Design: Twenty-six anonymized, previously diagnosed clinical cases, including clinical features and images, were selected. The assistant was trained using scientific references and configured to generate diagnostic hypotheses and suggest complementary exams.

Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient.

Small cell osteosarcoma (SCOS) is a rare variant of conventional osteosarcoma, characterized by tumor cells of small size and uniform morphology, which can lead to diagnostic confusion with other small cell tumors, requiring a detailed diagnostic approach. The manifestation in a child adds a degree of complexity, as the management of malignant tumours in paediatric patients requires specific considerations to minimize the long-term side effects of oncological treatment and preserve the structural and functional development of the orofacial region. This report concerns an 8-year-old female patient referred to the Oral and Maxillofacial Surgery outpatient clinic with progressive swelling in the right maxillofacial region, initially asymptomatic, but progressing to pain and difficulty chewing.

TeleCleft: Development and Evaluation of a Mobile Application for Monitoring Cleft Patients.

ObjectiveDevelopment and evaluation of a mobile application for remote monitoring and guidance of pediatric patients diagnosed with cleft lip and/or palate (CL ± P) and their caregivers.DesignThis is a pilot cross-sectional, applied, and quantitative study.SettingThe study was conducted in two tertiary care treatment centers in Brazil.

Digital resources in the monitoring of patients with cleft lip and palate: protocol for a scoping review.

Introduction: Cleft lip and/or palate (CL+/-P) is a congenital malformation affecting the lip and palate, requiring long-term treatment due to potential associated complications. For this reason, it is important for the patient to be continuously monitored and followed for health promotion and prevention, as well as improving the quality of life. The aim of this scoping review protocol is to identify and map the available evidence regarding the application of digital resources and technologies in the monitoring and follow-up of patients with CL+/-P.

Telehealth in oral medicine: A cross-sectional evaluation based on a mobile application.

Background: Teledentistry is considered a good tool in the diagnostic process. In oral medicine, there is a low number of trained professionals and dentists have difficulty in diagnosing and treating oral lesions.

Objective: We aimed to perform a cross-sectional evaluation based on the mobile application for oral diagnosis using a mobile application in a Brazilian State.

A case series of mucormycosis after covid infection in two hospitals.

This paper aims to discuss clinical aspects of mucormycosis. This case series was conducted in two services, comprising six mucormycosis cases during COVID-19 pandemic. About gender, there are 4 (66.

YouTube™ and oral lichen planus: an appraisal of the educational quality of information.

The objective of this study was to analyze the quality of videos on oral lichen planus (OLP) available in YouTube™. A cross-sectional analytical study was conducted by searching the video sharing platform YouTube™. Videos aimed at clarifying the etiological and clinical characteristics, diagnostic criteria, treatment, and prognosis of OLP were included.

Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update.

Primary intraosseous oral squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that affects the jaws. Despite its aggressive biological behavior, there are no studies that evaluated the clinicopathological features of this tumor and parameters associated with its prognosis. The objective of the present study was to conduct a systematic review of the available data on oral and maxillofacial PIOSCC in order to determine its clinicopathological characteristics and biological behavior.

Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor.

Objectives: The aim of this systematic review was to provide an overview of the oral and maxillofacial solitary fibrous tumor (SFT) in order to determine its clinicopathologic characteristics and biological behavior.

Methods: We conducted a systematic review in May 2019 in multiple databases. Cases diagnosed as SFT in the oral cavity and maxillofacial complex were included.