Fire cupping inspired negative-pressure microneedle syringes loaded with herb berberine-based nano composite for psoriasis therapy.

Psoriasis, an immune-mediated chronic inflammatory skin disorder, poses challenges for topical treatment due to the thickening of the stratum corneum, hindering drug penetration. Furthermore, long-term use of chemical drugs may lead to immunosuppression and abnormal hepatic or renal dysfunction. Inspired by traditional Chinese fire cupping (Ba Huo Guan), a negative-pressure microneedle syringe therapy has been proposed here for psoriasis treatment.

A Fluorescence/Colorimetric Synergistic-Enhanced Type-I Heterostructured MOF@QDs for Both Multi-Depth Food-Freshness Prediction and Extra Preservation.

Spoiled food has significantly impacted the global economy and public health, which increases worldwide concern about monitoring and preserving food freshness. Herein, a multi-functional type-I heterojunction (Eu@ZMC) is designed by europium metal-organic framework (EuMOF), zinc oxide quantum dots (ZnO QDs), and chlorogenic acid (CGA). Eu@ZMC achieves ratiometric fluorescent/colorimetric sensing of pH and biogenic amines to detect freshness.

Reactive oxide species and ultrasound dual-responsive bilayer microneedle array for in-situ sequential therapy of acute myocardial infarction.

Acute myocardial infarction (AMI) resulting from coronary artery occlusion stands as the predominant cause of cardiovascular disability and mortality worldwide. An all-encompassing treatment strategy targeting pathological processes of oxidative stress, inflammation, proliferation and fibrotic remodeling post-AMI is anticipated to enhance therapeutic outcomes. Herein, an up-down-structured bilayer microneedle (Ce-CLMs-BMN) with reactive oxygen species (ROS) and ultrasound (US) dual-responsiveness is proposed for AMI in-situ sequential therapy.

Rapid formed temperature-sensitive hydrogel for the multi-effective wound healing of deep second-degree burn with shikonin based scar prevention.

Burns are a significant public health issue worldwide, resulting in prolonged hospitalization, disfigurement, disability and, in severe cases, death. Among them, deep second-degree burns are often accompanied by bacterial infections, insufficient blood flow, excessive skin fibroblasts proliferation and collagen deposition, all of which contribute to poor wound healing and scarring following recovery. In this study, SNP/MCNs-SKN-chitosan-β-glycerophosphate hydrogel (MSSH), a hydrogel composed of a temperature-sensitive chitosan-β-glycerophosphate hydrogel matrix (CGH), mesoporous carbon nanospheres (MCNs), nitric oxide (NO) donor sodium nitroprusside (SNP) and anti-scarring substance shikonin (SKN), is intended for use as a biomedical material.

Smartphone conducted DNA portable quantitative detection platform based on photonic crystals chip and magnetic nanoparticles.

It is of great significance to develop a highly sensitive and intuitive virus detection tool. A portable platform is constructed for quantitative detection of viral DNA based on the principle of fluorescence resonance energy transfer (FRET) between upconversion nanoparticles (UCNPs) and graphene oxide nanosheets (GOs) in this work. To implement a high sensitivity and low detection limit, GOs are modified by magnetic nanoparticles to prepare magnetic graphene oxide nanosheets (MGOs).

Hair Derived Microneedle Patches for Both Diabetic Foot Ulcer Prevention and Healing.

The large amount of reactive oxygen species (ROS) produced by high glucose metabolism in diabetic patients not only induces inflammation but also damages blood vessels, finally resulting in low limb temperature, and the high glucose environment in diabetic patients also makes them susceptible to bacterial infection. Therefore, diabetic foot ulcer (DFU) usually presents as a nonhealing wound. To efficaciously prevent and treat DFU, we proposed a near-infrared (NIR) responsive microneedle (MN) patch hierarchical microparticle (HMP)-ZnO-MN-vascular endothelial growth factor and basic fibroblast growth factor (H-Z-MN-VEGF&bFGF), which could deliver drugs to the limbs painlessly, accurately, and controllably under NIR irradiation.

Upconversion nanoparticles regulated drug & gas dual-effective nanoplatform for the targeting cooperated therapy of thrombus and anticoagulation.

Thromboembolism is the leading cause of cardiovascular mortality. Currently, for the lack of targeting, short half-life, low bioavailability and high bleeding risk of the classical thrombolytic drugs, pharmacological thrombolysis is usually a slow process based on micro-pumping. In addition, frequently monitoring and regulating coagulation functions are also required during (and after) the process of thrombolysis.

Dual-Effective Chronic Wounds Management System through a Monoglyceride Binary Blend Matrix Based Thermal-Responsive Phase-Transition Substrate.

A new monoglyceride-based heat-sensitive substrate is proposed, for the first time, as a wound management system. First, an appropriate portion of glyceryl monooleate (GMO) and glyceryl monostearate (GMS) is mixed to provide a thermal phase responsive matrix (GMO-GMS, GG). Subsequently, to improve the photothermal responsive and antibacterial performance, silver nanoparticles (Ag) decorated reduced graphene oxide (rGO) nanocomposite (rGO-Ag) is added to the GG matrix to obtain (GG-rGO-Ag).

Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity.

A black phosphorus (BP)-nanosheet-based drug-delivery system containing a therapeutic drug (Fluoxetine, Flu) is synthesized. According to subsequent behavioral, biochemical, and electrophysiological analysis, BP-Flu, after irradiated with near-infrared light (808 nm), can significantly reduce the therapy time of depression. Meanwhile, the inherent biotoxicity of Flu is also alleviated.