Publications by authors named "Hanhai Mao"
Astacins, a family of zinc metalloproteinases, are involved in invasion and tissue migration processes in a variety of parasites. An astacin-like proteinases have been detected in the excretory-secretory products (ESPs) of Trichinella spiralis (T. spiralis), zinc metalloproteinase Nas-14 (TsNas14), but its function in T.
View Article and Find Full Text PDFThe effect of β-Glucan induced intestinal trained immunity against Trichinella spiralis infection.
Vet Parasitol
January 2025
Parasitic helminth Trichinella spiralis (Ts) induce mixed Th1/Th2 response with predominant type 2 immune responses, with protective immunity mediated by interleukin (IL)-4, IL-5, and IL-13. β-Glucan (BG) has been shown to have the ability to induce trained immunity, confers non-specific protection from secondary infections. However, whether BG-induced trained immunity played a role in protective type 2 immunity against Ts infection is unclear.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of gut microbiota in cardiac fibrosis caused by the helminth Trichinella spiralis, using infected mice as a model.
- Findings show that depleting gut microbes with antibiotics worsens cardiac fibrosis, while restoring microbiota through fecal transplants helps alleviate the condition.
- Increased levels of the gut microbe Akkermansia muciniphila in infected mice improve cardiac fibrosis, suggesting a potential therapeutic approach through oral supplementation.