A Spatiotemporally Controllable DNA Hydrogel Mesh for Focused Antimetastasis Therapy of Cancer.

Cancer is one of the most commonly diagnosed diseases with high mortality, and approximately 50% of patients are prone to present metastasis after various treatments. The shedding of circulating tumor cells (CTCs) during tumor therapy is the root cause of metastasis. In this work, we proposed a focused antimetastasis therapy strategy based on a spatiotemporally controllable DNA hydrogel mesh (SNARE: just like a turtle trapped in the jar) in vivo.

Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5-Mediated GSK-3β/c-Myc Signaling Pathway.

Daidzin (DZN) is a natural flavonoid compound derived from soybeans that has recently been recognized for its potential antitumor properties. In traditional Chinese medicine, soybeans and their extracts are extensively used to prevent and treat various diseases. To evaluate the therapeutic efficacy of DZN on human glioblastoma through in vivo and in vitro experiments, and through multi-omics analyses to elucidate potential molecular mechanisms.

Hydrolyzing Laminaria japonica with a combination of microbial alginate lyase and cellulase.

A novel seaweed-hydrolyzing strain designated as Pseudoalteromonas sp. Alg6B was isolated from the surface of brown seaweed (Laminaria japonica). The activity of crude alginate lyase produced by Alg6B was 54.

Isolation, purification, characterization, and antioxidant activity of low-molecular-weight polysaccharides from Sparassis latifolia.

Six polysaccharides (SF-FB11, SF-HW21, SF-CA31, SF-HA41, SF-FF51, and SF-FR61) of similar molecular weights (MW) (30-50 kDa) were extracted from the fermentation liquor, mycelia, and basidiomata of Sparassis latifolia by different methods. Structural analyses of these purified polysaccharides indicated that they were all branched, with a degree of branching (DB) ranging from 0.2 to 0.

Bioconversion of Flavonoid Glycosides from Leaves into Flavonoid Aglycones by .

The flowering process has been reported to play crucial roles in improving the flavor and efficacy of fermented tea. leaves containing many beneficial ingredients are a suitable plant source for tea processing. In this study, we isolated a β-glucosidase-producing fungus BSX001 from the fermented tea and used leaves (HRL) as a substrate to explore the detailed process of bioconversion of some important functional factors.