Solution-Processed Multivalent Molybdenum Oxide Tailoring Band Alignment for Efficient SbS Solar Cells.

Owing to its outstanding photoelectric characteristics, SbS has witnessed rapid development as a light-absorbing material for solar cells. However, the traditional utilization of Spiro-OMeTAD and PbS as hole transport layers (HTLs) in SbS solar cells poses significant challenges regarding stability and environmental toxicity. In this work, a solution-processed high-quality and smooth molybdenum oxide (MoO, 2 ≤ x ≤ 3) HTL is successfully applied in SbS solar cells, boosting the fill factor from 15.

Oxygen-Assisted Tailoring of Evaporated PbS Hole Transport Layer for Highly Efficient Antimony Sulfide Solar Cells.

Antimony sulfide (SbS) is regarded as one of the potential candidates for the next generation of photovoltaic absorber due to its excellent photoelectric properties. However, the selection and optimization of the hole transport layer (HTL) is still a major challenge for efficiency breakthrough of the SbS solar cells. In this work, lead sulfide (PbS) is deposited as a HTL of the SbS device by thermal evaporation for the first time.

Trends and frontiers in signal amplification for aptamer-based tumor detection: A bibliometric analysis.

Background: Malignant tumors are one of the leading causes of death worldwide, imposing a substantial economic and social burden. Early detection is the key to improving cure rates and reducing mortality rates, which requires the development of sensitive early detection technologies. Signal amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from researchers.

Simulation of highly efficient GeSe-based solar cells with SCAPS-1D.

Recently GeSe has developed as a promising light harvesting material by enjoying to its optical and electrical features as well as earth-abundant and low-toxic constituent elements. Nevertheless, the power conversion efficiency of GeSe-based solar cells yet lags far behind the Shockley-Queisser limit. In this work, we systematically designed, simulated and analyzed the highly efficient GeSe thin-film solar cells by SCAPS-1D.

Combination of multiple nucleic acid aptamers for precision detection of tumors based on optical methods.

Background And Purpose: Nucleic acid aptamers are a novel molecular recognition tool that is functionally similar to antibodies but superior to antibodies in terms of thermal stability, structural modification, preparation, and cost, and therefore hold great promise for molecular detection. However, due to the limitations of a single aptamer in molecular detection, the multiple aptamer combination for bioanalysis has received much attention. Here, we reviewed the progress of tumor precision detection based on the combination of multiple nucleic acid aptamers and optical methods and discussed its challenges and prospects.

Inhibitors Targeting Multiple Janus Kinases From Mediate Inhibition and Apoptosis Against Gastric Cancer Cells the Estrogen Pathway.

Janus kinases (JAKs) play a key role in subtly regulating proliferation, apoptosis, and differentiation of cancer cells, and their inhibitors are actively sought as new drug leads. By developing JAKs based affinity ultrafiltration method coupled with LC/Q-TOF-MS in order to discover selective JAKs inhibitors from total quaternary alkaloids (QAs) from , peak 19 (Berberine) and peak 21 (Chelerythrine) were revealed to exhibit notable selectivity on JAK1, JAK2, and JAK3 over Tyk2. In addition, Chelerythrine showed stronger inhibitory activity than the positive control (Cerdulatinib) on gastric cancer cells (AGS), while Berberine, with weaker inhibition.

Potential Antioxidative Components in Revealed by Bio-Affinity Ultrafiltration with SOD and XOD.

() has been widely used due to its diverse pharmacological activities. However, there are currently few studies on its responsible antioxidant ingredients against superoxide dismutase (SOD) and xanthine oxidase (XOD). In this study, the antioxidant activities of were evaluated by a 2,2'-azinobis-(3-ethyl-benzthiazoline)-6-sulfonic acid) and ferric-ion-reducing antioxidant power method.

Stimulation of ROS Generation by Extract of Leading to G/G Cell Cycle Arrest and Antiproliferation in A549 Cells.

Sprague (WU) is a traditional medicinal plant used for the treatment of various diseases, including cancer, in Africa. This study aimed to evaluate the anti-non-small cell lung cancer (NSCLC) activities of WU against A549 cells and to reveal potential molecular mechanisms. The cytotoxicity of various WU extracts was evaluated with HeLa (cervical cancer), HepG2 (liver cancer), HT-29 (colorectal cancer), and A549 (non-small cell lung cancer) cells by means of Sulforhodamine B (SRB) assay.

Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Employing Multi-Target Affinity Ultrafiltration and LC-MS.

Previous reports have illustrated that the incidence and mortality of cancer are increasing year by year worldwide. In addition, the occurrence, development, recurrence and metastasis of cancer are closely related to inflammation, which is a kind of defensive response of human body to various stimuli. As an important medicinal plant in Africa, has been reported to have certain anti-inflammatory and anti-proliferative activities, but its specific components and mechanisms of action remain elusive.

New Lignanamides with Antioxidant and Anti-Inflammatory Activities Screened Out and Identified from Combining Affinity Ultrafiltration LC-MS with SOD and XOD Enzymes.

, also known as "green heart," is widely used for the treatment of various diseases as a traditional ethnomedicinal plant in local communities in Africa. In this work, 9 and 12 potential superoxide dismutase (SOD) and xanthine oxidase (XOD) ligands from were quickly screened out by combining SOD and XOD affinity ultrafiltration with LC-MS, respectively. In this way, four new lignanamides (compounds -) and one new macrocyclic glycoside (compound ), along with three known compounds (compounds , , and ), were isolated and identified firstly in this species.

Antioxidant and Antiproliferative Potentials of and Its Bioactive Polyphenol Metabolites.

Delile (Moraceae), a reputed plant that is used in herbal medicine, is of high medicinal and nutritional value in local communities primarily ascribed to its phytochemical profile. Currently, there are hardly any fine details on the chemical profiling and pharmacological evaluation of this species. In this study, the flavonoids and phenolics contents of the ethanol extracts and four extracted fractions (petroleum ether (PE), ethyl acetate (EA), -butanol, and water) of the stem bark of were firstly quantified.

High APOBEC1 Complementation Factor Expression Positively Modulates the Proliferation, Invasion, and Migration of Endometrial Cancer Cells Through Regulating P53/P21 Signaling Pathway.

APOBEC1 complementation factor () is a component of the apolipoprotein-B messenger RNA editing complex that participates in various cellular processes and acts as an oncogene in many cancers. In this study, it was aimed to investigate the roles of and its potential mechanism in endometrial cancer (EC). Gene expression prolife was downloaded from The Cancer Genome Atlas database.

Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents.

Moringa oleifera Lam. (M. oleifera) leaves have long been consumed as both nutritive vegetable and popular folk medicine for hyperglycemia and hyperlipidemia in Kenya communities.

Antioxidant, Anti-inflammatory Activities and Polyphenol Profile of Rhamnus prinoides.

Rhamnus prinoides L'Herit (R. prinoides) has long been widely consumed as folk medicine in Kenya and other Africa countries. Previous studies indicated that polyphenols were abundant in genus Rhamnus and exhibited outstanding antioxidant and anti-inflammatory activities.

[Protective Effect of Salvianolic Acid B on Intestinal Ischemia-reperfusion Injury in Rats].

To investigate the protective effect of salvianolic acid B(SAB)on the intestinal tract of rats after intestinal ischemia-reperfusion injury(IIRI). Forty-eight healthy male SD rats were equally randomized into IIRI group,SAB+IIRI group,sham control group,and SAB+sham control group. The malonyldialdehyde(MDA)level and superoxide dismutase(SOD)activity in the ileum were measured in each group according to the kit instructions,the transcription levels of inflammatory factors in the ileum of rats were detected by real-time fluorescence quantitative RT-PCR,the secretion level of inflammatory factors was detected by ELISA,and the effects of intestinal ischemia-reperfusion on intestinal permeability and histological lesions were measured by histopathology.

Antioxidant and Anti-Inflammatory Activities of the Crude Extracts of from Kenya and Their Correlations with Flavonoids.

Lam. () is commonly distributed and utilized in tropical and sub-tropical areas. There has been a large number of reports on the antioxidant and anti-inflammatory activity of its leaves, but only a few about its seeds and roots.

In-situ headspace analysis of metabolic carbon dioxide of aerobic bacteria for assessing antimicrobial activity of natural products.

Headspace analysis of the volatile metabolites has been used as a good strategy for monitoring the microbial growth in several applications, but never been established for the evaluation of the activity of microbial inhibitor in the field of drug screening from natural products. We report on a new method for the determination of antimicrobial activity of drug compounds or crude extracts from natural products by measuring the amount of metabolic carbon dioxide produced in the drug-bacteria incubation system. 2 mL of medium containing bacteria and drug of interest was incubated at 37 °C for 24 h.

Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule.

The antioxidant and anti-inflammatory mechanisms of action of flavonoids in lotus plumule were systematically analyzed using radical scavenging assays and ELISA kits. By this means, flavonoids displayed significant antioxidant activity by donating electron, H atom as well as capturing DPPH and ABTS free radicals, and anti-inflammatory effect by inhibiting the production of the inflammatory mediators (NO radicals, PGE and TNF-α) and pro-inflammatory cytokines (IL-1β and IL-6). Meanwhile, the bioactive components against inflammation targeting COX-2 were also revealed using ultrafiltration coupled to LC-MS (UF-LC/MS).

Recent development in mass spectrometry and its hyphenated techniques for the analysis of medicinal plants.

Introduction: Medicinal plants are gaining increasing attention worldwide due to their empirical therapeutic efficacy and being a huge natural compound pool for new drug discovery and development. The efficacy, safety and quality of medicinal plants are the main concerns, which are highly dependent on the comprehensive analysis of chemical components in the medicinal plants. With the advances in mass spectrometry (MS) techniques, comprehensive analysis and fast identification of complex phytochemical components have become feasible, and may meet the needs, for the analysis of medicinal plants.

[Effects of P and K fertilizer on content of coumarin and yield of Glehnia littoralis].

By a orthogonal experiment, the influence of different ratio of phosphorus and potassium fertilizers on imperatorin, isoimperatorin and psoralen contents and yield of Glehnia littoralis were studied. The results showed that root dry weight and the yield of G. littoralis increased when reasonably applied phosphorus fertilizer combined with potassium fertilizer within a certain range.

miR-132 can inhibit glioma cells invasion and migration by target MMP16 in vitro.

Gliomas are the most common malignant primary brain tumors, and new clinical biomarkers and therapeutic targets are imminently required. MicroRNAs (miRNAs) are a novel class of small non-coding RNAs (∼22nt) involved in the regulation of various biological processes. Here, by using real-time polymerase chain reaction, miRNA-132 was found to be significantly deregulated in glioma tissues.

Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop.

Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca(2+) concentration in synaptosomes.

miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells.

Malignant gliomas are the most common primary brain tumors, and the molecular mechanisms involving their progression and recurrence are still largely unclear. Substantial data indicate that the oncogene miR-494-3p is significantly elevated in gliomas, but the molecular functions of miR-494-3p in gliomagenesis are largely unknown. The present study aimed to explore the role of miR-494-3p and its molecular mechanism in human brain gliomas, malignant glioma cell lines, and cancer stem-like cells.

Sleep status of cervical cancer patients and predictors of poor sleep quality during adjuvant therapy.

Purpose: This study was designed to detect the prevalence of poor sleep quality in cervical cancer patients before and after adjuvant therapy, determine whether the prevalence of poor sleep quality in cervical cancer patients is higher than that in the general population, and analyze the factors associated with poor sleep quality.

Methods: A total of 76 stages I and II cervical cancer patients and 116 female residents completed the Pittsburgh Sleep Quality Index (PSQI). Patient Neurotoxicity Questionnaire (PNQ), Distress Thermometer (DT), Multidimensional Fatigue Inventory, and Hospital Anxiety and Depression Scale were used to measure the patients' chemotherapy-induced peripheral neurotoxicity (CIPN), psychological distress, fatigue, anxiety, and depression.