Structural and functional analysis of VYD222: a broadly neutralizing antibody against SARS-CoV-2 variants.

Extensive mutations in SARS-CoV-2 spike protein have rendered most therapeutic monoclonal antibodies (mAbs) ineffective. However, here we describe VYD222 (pemivibart), a human mAb re-engineered from ADG20 (adintrevimab), which maintains potency despite substantial virus evolution. VYD222 received FDA Emergency Use Authorization for pre-exposure prophylaxis of COVID-19 in certain immunocompromised adults and adolescents.

High Blood Pressure Among Emergency Department Patients: Effects of Educational Intervention.

Introduction Hypertension is a significant global health issue. It is estimated that approximately half of adults in the United States have hypertension (approximately 119 million adults). Although emergent treatment is not indicated for asymptomatic hypertension, patients presenting to the emergency department (ED) with hypertension may represent an opportunity for patient education and improved health outcomes.

Investigating the relationship between gut microbiota and electrocortical signatures of feedback processing: an ERP study.

Rationale: Evaluative processing of action outcome is considered crucial for learning and adaptive adjustments of behaviour. Feedback-related negativity (FRN) is an event-related potential elicited by feedback presentation, with implicated neural sources in the anterior cingulate cortex. Bidirectional communications within the brain-gut-microbiota axis modulate cognition and behaviour, and microbial composition has been associated with medial prefrontal cortex function and clinical risk for depression.

Large Aneurysm Size is Associated with Increased Short and Long Term Mortality after Branched and Fenestrated Repair for Thoraco-abdominal and Complex Abdominal Aortic Aneurysms.

Objective: This study assessed outcomes following fenestrated and branched endovascular aortic repair (F/BEVAR) for thoraco-abdominal aortic aneurysms (TAAAs) and complex abdominal aortic aneurysms (cAAAs) based on aneurysm size (small, medium, and large).

Methods: Patients who underwent elective F/BEVAR for the treatment of TAAAs and cAAAs (only juxtarenal aneurysms) from 2013 - 2022 in the Vascular Quality Initiative database were included. Aneurysm size was categorised as small (< 5.

Symptom Burden and Intervention Outcomes in Idiopathic Normal Pressure Hydrocephalus: A Multicenter Retrospective Study.

Introduction: Normal pressure hydrocephalus (NPH) is a potentially reversible cause of dementia, characterized by a clinical triad of gait disturbance, urinary incontinence, and cognitive decline. Despite suggestive radiologic findings, many patients remain untreated. This study aimed to determine the clinical correlation between radiographic findings of NPH and clinical symptoms.

Longitudinal patterns of antidepressant and benzodiazepine use associated with injurious falls in older adults with depression: a retrospective cohort study.

Background: Cross-sectional studies have shown that antidepressants (ADs) and benzodiazepines (BZDs) are commonly co-prescribed for depression, potentially increasing the risk of falls and related injuries (FRI) compared to monotherapies. However, little is known about the longitudinal dosing patterns (i.e.

Pseudomonas infections persisting after CFTR modulators are widespread throughout the lungs and drive lung inflammation.

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators improve the physiological defect causing cystic fibrosis, but the lungs of most people remain infected and inflamed. A leading hypothesis implicates damaged segments as the cause of persistent infection and predicts that mildly diseased segments within an individual's lungs will clear after treatment, whereas severely diseased segments will not. Our findings contradict this hypothesis.

A longitudinal mediation analysis of relationship catastrophizing, perceived partner support, and sexual well-being in couples seeking medically assisted reproduction.

Couples navigating medically assisted reproduction (MAR) may respond to relationship stressors by catastrophizing. Catastrophizers may be more likely to seek support indirectly; partners may miss these cues such that their responses are seen as unsupportive, which may impact sexual desire and distress. We investigated whether relationship catastrophizing predicted lower sexual desire and greater sexual distress, via lower perceived partner support, across 1 year.

Anatomic predictors of distal landing zone failure after endovascular repair of thoracic aortic aneurysm†.

Objectives: To analyse anatomic factors of the distal landing zone (dLZ) associated with the durability of endovascular repair of thoracic aortic aneurysm (TAA).

Methods: Consecutive patients undergoing thoracic endovascular aortic repair (TEVAR) for undissected TAA were queried from a single centre from 2004 to 2022. Patient and operative factors were considered as well as detailed anatomic factors at the dLZ assessed by 3D reconstruction of pre-TEVAR imaging.

Interoception, personality, and internet use: Preliminary insights into their association.

Problematic Internet Use (PIU) is increasingly recognized as a concern among internet users, prompting investigations into the factors that may predispose individuals to PIU. Interoceptive awareness, one of cognitive-perceptual factors, refers to the ability to perceive internal bodily sensations and has been shown to play a significant role in the onset and maintenance of drug addiction. However, its relationship with PIU remains underexplored.

"Honoring Beautiful Connections": LGBTQA+ Perspectives on Providing Safe and Inclusive Psychedelic-Assisted Therapy.

Psychedelic-Assisted Therapy (PAT) is a rapidly growing therapeutic approach that to date has rarely considered the nuanced needs of LGBTQA+ individuals. This study explores what LGBTQA+ individuals consider important for healthcare providers (HCPs) to consider when providing PAT. A global sample of LGBTQA+ individuals aged 18+ who had experience using a classic psychedelic compound at least once in a non-microdose manner were recruited into an online survey.

Health Maintenance and Unique Health Needs of the Perimenopausal and Postmenopausal Woman with Inflammatory Bowel Disease.

Background: The care of women with inflammatory bowel disease (IBD) presents unique challenges for physicians given the impact of their disease on the management of issues throughout their lifespan. Preventative care plays a critical role, given the long-term sequelae associated with chronic inflammation and immunosuppressive therapy. Despite this, there remains a gap in knowledge regarding the health maintenance needs of women over 40, particularly those in perimenopausal and postmenopausal stages.

Sepsis Among Hospitalized Patients: Events in the 30 Days Preceding the Diagnosis.

Introduction Sepsis is defined as life-threatening organ dysfunction due to a dysregulated host response to infection, and is one of the leading causes of morbidity and mortality globally. This study was undertaken to investigate the role of healthcare encounters and diagnostic test results in the 30 days preceding a sepsis diagnosis. Methods In this single-center retrospective chart review, eligible subjects were 18 years of age and older who presented to the ED and were diagnosed with either sepsis or septic shock in the ED or inpatient setting between January 2020 and September 2023.

Aneurysm sac regression after fenestrated or branched endovascular aortic repair is associated with superior long-term survival.

Objective: Aneurysm sac behavior after fenestrated or branched endovascular repair (FB-EVAR) of thoracoabdominal aortic aneurysms (TAAAs) remains a key knowledge gap. The purpose of this study was to identify independent predictors of sac behavior after FB-EVAR and assess the relationship between sac behavior and long-term survival.

Methods: Patients undergoing FB-EVAR between 2005 and 2023, in 10 physician-sponsored investigational device exemption studies in the United States, were analyzed.

Long-term outcomes of thoracic endovascular aortic repair for descending thoracic aortic aneurysms based on pooled results from FDA clinical trials.

Objective: Thoracic endovascular aortic repair (TEVAR) is the preferred treatment for descending thoracic aortic aneurysms, but long-term data are limited. This study assessed long-term results of TEVAR in early recipients of TEVAR devices who were enrolled in US Food and Drug Administration investigational device exemption clinical trials for aneurysm.

Methods: This was a single-center retrospective study including 179 patients enrolled in 14 clinical trials for TEVAR for descending thoracic aortic aneurysm between 2000 and 2019.

Pediatric Orthopaedic Studies Published Open Access are Associated with Increased Citation Rates.

Background: Open access (OA) articles are freely accessible online, either on the publisher/journal website or in a repository, a publicly available, free-of-charge online database. The primary aim of this study was to investigate whether OA publication confers a citation advantage in pediatric orthopaedics.

Methods: Pediatric orthopaedic studies published in English from January 1, 2012 to June 30, 2012 were identified through Excerpta medica database , Cochrane, and PubMed.

Utility of Incorporating Radiological Findings of Right Heart Strain in Patients With Acute Pulmonary Embolism for Risk Stratification of Adverse Outcomes: A Retrospective Analysis.

Background: Right heart (RH) strain in the setting of pulmonary embolisms can significantly increase the risk of mortality. Thus, screening for risk of complications in these patients is crucial. The goal of our study was to assess the strength of specific diagnostic findings of RH strain for predicting adverse outcomes including mortality, hospital length of stay, and the requirement of advanced interventions.

An integrated machine learning-based prognostic model in head and neck cancer using the systemic inflammatory response index and correlations with patient reported financial toxicity.

Objective: To investigate the prognostic utility of systemic inflammatory response index (SIRI) as a biological readout of stress associated immune modulation in head and neck cancer patients who underwent radiation therapy.

Methods: Random survival forest machine learning was used to model survival in 568 head and neck cancer patients. SIRI was calculated via pre-treatment bloodwork.

Hallways Feel Like Homelessness: The Geriatric Boarder Experience.

Background: Boarding in the Emergency Department (ED) is associated with increased delirium, morbidity, and mortality. Geriatric patients are especially vulnerable to these harms and are more likely to board for a prolonged time. Although multiple studies have investigated clinical outcomes for older adults, we present the first study examining the subjective experience of geriatric boarders through qualitative methods.

Underinvested, Under-Referred, and Underserved: Applying a Gender Equity Continuum Framework in Cancer Control Continuum Programs and Policies to Expand to Transgender and Nonbinary Populations.

Gender-inclusive and gender-specific approaches are critically needed in cancer control continuum services to recognize and meet the needs of transgender and nonbinary (trans) populations. Current research, programs, and policies largely cater to cisgender populations and subscribe to a binary, gendered cisnormative ideology, both within health care systems and insurance policies, leaving trans people's cancer prevention and treatment needs neglected. Such disparities can be attributed to the significant gap in funding and research to address trans cancer prevention and treatment.

The Effect of Smoking Cessation on Outcomes of Thoracic Endovascular Aortic Repair.

Background: Smoking is known to be a strong predictive factor for deleterious outcomes after surgical procedures; however, there is limited research that has focused on the effect of smoking cessation on the outcomes of thoracic endovascular aortic repair (TEVAR). Using a multi-institutional database, we aimed to determine if smoking cessation was associated with improved outcomes following TEVAR.

Methods: Patients undergoing thoracic endovascular aortic repair in Vascular Quality Initiative from 2013 to 2023 were categorized into three groups: never smokers (NS), those who quit smoking (QS) >30 days prior, or current smokers (CS) who quit ≤30 days prior or never quit.

Venous lactate as a tool for the Risk-Stratification of patients with acute pulmonary embolism: A retrospective cohort study.

Introduction: Prognostication in pulmonary embolism (PE) is crucial due to the broad range of clinical severity, and biomarkers such as arterial lactate are considered helpful markers for illness severity. Venous lactate is more readily accessible, but its prognostic value in acute PE has not been widely evaluated. We aimed to determine optimal cutoffs for venous lactate in predicting adverse outcomes in patients with PE.

Harm reduction interventions for AYA who use opioids: A scoping review.

Background: Adolescents and young adults (AYA) are highly vulnerable to substance use and substance use-related harms. Existing harm reduction programs do not optimally serve AYA, and there is minimal data regarding harm reduction interventions specific to AYA.

Methods: We conducted a preliminary search in MEDLINE (Ovid) to identify names used to describe harm reduction interventions to include in the final search.

Outcomes of High Risk and Complicated Type B Aortic Dissections Treated with Thoracic Endovascular Aortic Repair.

Objective: The Society for Vascular Surgery (SVS) and the Society for Thoracic Surgery published reporting standards defining complicated and uncomplicated type B aortic dissections (TBADs) and included previously undefined high risk features. This retrospective review of multi-institution SVS Vascular Quality Initiative (VQI) post-approval study (VQI PAS) data aimed to evaluate the outcomes of patients with high risk TBAD (hrTBAD) and complicated TBAD (cTBAD) treated with thoracic endovascular aortic repair (TEVAR).

Methods: The data of 641 patients collected from 2013 to 2023 were included.