Two-Scope Technique for Tracheal Epithelial-Myoepithelial Carcinoma-A Rare Case Report and Review.

Epithelial myoepithelial carcinoma (EMC) is an exceptionally uncommon salivary gland type tumour of the lung accounting for only 0.1% to 1% of all primary pulmonary malignancies. We describe a 40-year-old man presenting with hemoptysis, in whom computed tomography (CT) of the chest revealed an endoluminal mass in the upper trachea.

Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia.

Right heart catheterization (RHC) is the gold-standard for diagnosis of pulmonary hypertension (PH) but is a terminal procedure in neonatal mice. The objective was to validate echocardiographic measures of PH to establish the diagnostic capability against pulmonary vascular histology in neonatal mice. Adult mice, exposed to hypoxia or normoxia, were assessed by echocardiography and RHC to evaluate right ventricle (RV) morphometry and function.

Navigating the Efficacy and Safety Landscape of Duloxetine in Osteoarthritis Management: A Meta-Analysis of Randomized Controlled Trials.

Objective: To evaluate the efficacy and safety of duloxetine in treatment of osteoarthritis compared with placebo.

Method: We conducted a comprehensive search for pertinent randomized controlled trials (RCTs) across multiple databases, including PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Google scholar.

Iomeprol-induced acute generalised exanthematous pustulosis (AGEP).

Acute generalised exanthematous pustulosis (AGEP) is an uncommon but severe cutaneous adverse drug reaction characterised by the abrupt onset of numerous sterile, non-follicular pustules on erythematous and oedematous skin, often accompanied by fever and leucocytosis. Although medications are the primary aetiological factor, AGEP may also be precipitated by exposure to certain chemicals, dyes or infectious agents. Despite its low incidence, estimated at 1-5 cases per million each year, AGEP remains a clinically significant condition with potential for severe morbidity and, in rare cases, fatality.

Crosstalk Between Viral Envelop-E Protein and Host Innate Immune System: Exploring Pharmacological Targets and Agents.

The Envelope (E)-protein is a key structural element of enveloped viruses that plays a significant role in host-pathogen interactions, viral growth, and hijacking of host innate immune system. Due to lack of antiviral agents and significant adverse effects and less affordability of vaccines, the E-protein targeted drug development is gaining critical attention among the researchers. The present review explores the structural and genomic diversities of E-protein among animal viruses with special interest to flaviviruses, coronaviruses, and herpesviruses.

Evolution and Predictors of Right Ventricular Failure in Fontan Patients: A Case-Control Study.

Patients with single right ventricular morphology (SRV) may exhibit impaired function with increased morbidity, mortality, and need for cardiac transplant due to progressive SRV failure after the Fontan procedure. The aim of the study was to longitudinally characterize the cardiac mechanics and trajectory of disease evolution of SRV failure in Fontan patients. : We performed a case-controlled longitudinal study of 52 patients who underwent extracardiac Fontan palliation for SRV between 1994 and 2015 and compared echocardiographic measures of right ventricular (RV) function, RV-systemic vascular coupling and ventricular remodeling between patients who required heart transplants due to SRV failure (study group, = 26) and those who did not (control group, = 26).

Investigating SnOx/Graphene Oxide heterostructure for methane sensing and its application as a tunable light absorber for optoelectronic devices.

This study investigates the optical and electronic properties of SnOx/Graphene Oxide (SnOx/GO) heterostructures, focusing on their sensitivity and selectivity to methane adsorption and its tunable light absorption capabilities across different wavelength ranges. By categorizing SnOx/GO heterostructures into four types based on the oxygen mole fraction (x) of SnOx, notable differences are observed in their light absorption, extinction coefficient, and reflectance. Among these, Type-C heterostructures demonstrate the highest absorption coefficient (~1.

Understanding the acute care context to inform palliative care improvements: a qualitative study of hospital-based multidisciplinary clinicians.

Background: Population ageing and rising levels of non-communicable diseases are increasing the number of people living with and dying from advanced serious illnesses globally. Many of these people are hospitalised more than once in their last year of life. While there is sound evidence on what patients and their families require for safe and high-quality hospital palliative care, enabling this remains a challenge.

Stepped-care models for cancer symptom management: A systematic review of efficacy and cost-effectiveness.

Background: The delivery of clinical care services using personalised health approaches is an integral component of cancer care. This review synthesised evidence on the efficacy and cost-effectiveness of stepped-care interventions delivered to manage therapy-related symptoms in cancer populations compared to care-as-usual (CAU).

Methods: Systematic searches were conducted in MEDLINE, PsycINFO, Embase, Web of Science, Cochrane Library, National Health Service Economic Evaluation Database, and EconLit to identify studies published from Jan 2010 to Nov 2024.

Unveiling Exosome Potential: Transforming Treatments for Neurodegeneration.

Exosomes, tiny extracellular vesicles, hold significant potential as biological nanocarriers for diverse therapeutic agents due to their exceptional ability to navigate through the barriers of biological systems. This comprehensive review delves into the capability of exosomes in the therapy of neurodegenerative disorders, concentrating on their potential for targeted drug delivery. It examines the complex processes involved in exosome-mediated drug delivery, including targeting, cellular uptake, intracellular trafficking, and therapeutic release.

The effectiveness of nurse-led palliative care needs assessment on patients' quality of life and symptom burden: a systematic review.

Background: Optimal palliative care requires a correct assessment of needs. Nurses are well-placed to undertake this task, but the effectiveness of nurse-led palliative care needs assessment remains uncertain.

Aim: To evaluate the evidence regarding the impact of nurse-led palliative care needs assessment on adult patients with oncological and non-oncological illnesses quality of life, symptom burden and hospitalisations.

Assessment of stable carbon isotope ratios and source characterization of aerosols in ambient PM from the Indian COALESCE network.

This study explores the potential of stable carbon isotope (δC) composition of ambient carbonaceous aerosols in assessing the nature and apportionment of their sources. As part of the CarbOnaceous AerosoL Emissions, Source apportionment & ClimatE Impacts (COALESCE) network, δC measurements (n = 1120) were conducted on aerosol samples collected from eight key locations spread across India. The δC values of aerosols exhibit distinct spatial/temporal isotopic variabilities between background and polluted (urban) sites, and indicate an origin primarily from C-biomass, fossil fuels, vehicular emission sources, etc.

A 2D electrocardiogram signal compression algorithm using 1D discrete wavelet transform.

Electrocardiogram (ECG) signals are frequently acquired nowadays to detect various heart diseases. Nowadays, IoT-enabled wearable devices are in demand for distant or telemedicine-based healthcare applications. However, the acquisition process of ECG signals generates a huge amount of data, which negatively impacts the storage and transmission efficiency of these devices.

Efficacy and Safety of Oral Cloxacillin Versus Amoxicillin-Clavulanic Acid in Treating Pediatric Acute Bacterial Lymphadenitis.

Aim and objectives Acute bacterial lymphadenitis is one of the most common causes of lymphadenopathy in children, whose treatment algorithm is not well defined in literature to date. The most commonly used drug for this condition is amoxicillin-clavulanic acid. However, given escalating antibiotic resistance, the use of narrower-spectrum agents like cloxacillin could be preferred.

Effects of Cardiac Remodeling and Altered Mechanics on Cardiac Outcomes in Fulminant Myocarditis in Children: Insight from a Longitudinal Pilot Study.

Fulminant presentations of acute myocarditis can predict cardiac functional and patient outcomes. This longitudinal study compared pediatric cohorts with fulminant Multisystem Inflammatory Syndrome-related myocarditis (MISCM) vs non-COVID-19 viral myocarditis (VM) to test the hypothesis that the adverse left ventricular (LV) remodeling rather than the phenotype of presentation predicts clinical outcomes. This is a retrospective analysis of 54 children with MISCM (age 6 ± 4 years, weight 32.

Development of a package on the management of acute myocardial infarction for healthcare professionals at Jordan University Hospital.

Background: Acute myocardial infarction (AMI), commonly known as a heart attack, is one of the leading causes of death globally. While healthcare professionals possess fundamental knowledge of managing AMI, there are key areas that require improvement or where basic knowledge is lacking. Timely decision-making, collaboration with the healthcare team, and continuous patient monitoring are imperative for optimizing outcomes in AMI cases.

CMR Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study.

Background: Multisystem Inflammatory Syndrome in Children is characterized by high rates of acute cardiovascular involvement with rapid recovery of organ dysfunction. However, information regarding long-term sequelae is lacking. We sought to characterize the systolic function and myocardial tissue properties using cardiac magnetic resonance (CMR) imaging in a multicenter observational cohort of Multisystem Inflammatory Syndrome in Children patients.

Prediction of Pharmacokinetics of Valeric Acid: Alternative Tool to Minimize Animal Studies.

Background: The use of computer-aided toxicity and Pharmacokinetic (PK) prediction studies are of significant interest to pharmaceutical industries as a complementary approach to traditional experimental methods in predicting potential drug candidates.

Methods: In the present study, in-silico pharmacokinetic properties (ADME), drug-likeness, and toxicity profiles of valeric acid were examined using SwissADME and ADMETlab web tools.

Results: The drug-likeness prediction results revealed that valeric acid adheres to the Lipinski rule, Pfizer rule, and GlaxoSmithKline (GSK) rule.

An Expert Opinion on the Management of Frailty in Heart Failure from the Australian Cardiovascular Alliance National Taskforce.

Approximately 50% of all adults with heart failure (HF) are classified as frail. Frailty is a clinical state of 'accelerated ageing' that complicates management and results in adverse health outcomes. Despite recommendations for frailty assessment in HF guidelines, its implementation into routine clinical practice has been slow.

Estimating the impact of the COVID-19 pandemic on infectious disease notifications in Klang district, Malaysia, 2020-2022.

Objective: The COVID-19 pandemic disrupted disease surveillance systems globally, leading to reduced notifications of other infectious diseases. This study aims to estimate the impact of the COVID-19 pandemic on the infectious disease surveillance system in Klang district, Selangor state, Malaysia.

Methods: Data on notifiable diseases from 2014 to 2022 were sourced from the Klang District Health Office.

Mycosis fungoides and Sezary syndrome - Simplifying the approach for dermatologists. Part 2: Evaluation, staging, prognosis and treatment.

Cutaneous T-cell lymphoma is a heterogeneous group of T-cell neoplasms, of which mycosis fungoides and Sezary syndrome are the most common. The prognosis depends on the stage of the disease. The early stage follows a protracted course with a five-year disease-specific survival of greater than 95% and is treated with skin-directed topical therapies, phototherapy, and oral drugs like methotrexate.

Mycosis fungoides and Sézary syndrome - Simplifying the approach for dermatologists. Part 1: Etiopathogenesis, clinical features and evaluation.

Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of extranodal non-Hodgkin's lymphomas characterised by a cutaneous infiltration of malignant monoclonal T lymphocytes. While this broad spectrum of disease with its varied etiopathogenesis, clinical features and management options are well characterised, an approach from a dermatologist's perspective is lacking in the literature. We strive to elucidate the approach from a clinician's point of view, especially in respect of clinical examination, investigations, staging and management options that are available in the realm of the dermatologists.