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Approximately 50% of all adults with heart failure (HF) are classified as frail. Frailty is a clinical state of 'accelerated ageing' that complicates management and results in adverse health outcomes. Despite recommendations for frailty assessment in HF guidelines, its implementation into routine clinical practice has been slow. Further, evidence to inform models of care and pharmacological treatment for individuals with HF who are classified as frail is lacking. The complexity of management underscores the importance of tailoring models of care that can improve the focus on frailty through multidisciplinary care teams. Frailty can be reduced in some cases through the comprehensive geriatric assessment model of care, integrating treatment pillars such as exercise, nutrition, social engagement and support networks, and optimised medication use. A national agenda for action on frailty in the context of HF is needed to advance policy, practice, education, and research improve health outcomes for individuals affected. In November 2023 the Australian Cardiovascular Alliance (ACvA) facilitated a national workshop on frailty and HF with key experts. This has led to the development of a frailty and HF national taskforce with the aim to address major priorities and unmet needs. This statement is first step for the taskforce in implementing a national agenda for the management of frailty in HF. Here we outline key considerations for policy, practice, education, and research in Australia.
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http://dx.doi.org/10.1016/j.hlc.2025.01.012 | DOI Listing |
Arch Gerontol Geriatr
August 2025
Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, China. Electronic address:
Background: Frailty is a dynamic condition that may affect mental health. This study aimed to investigate the associations of frailty and its changes with the risks of depressive symptoms across multiple regions in aging populations.
Methods: Data were drawn from five cohort studies in the United States, England, Europe, China, and Mexico.
PLoS One
September 2025
Queen Alexandra Hospital, Portsmouth University Hospitals NHS Trust, Portsmouth, United Kingdom.
Background: The Hospital Frailty Risk Score (HFRS) has been widely used to identify patients at high risk of poor outcomes and to predict poor outcomes for older people. Although poor health outcomes are associated more with frailty than age, HFRS has been validated only for older people. This study aimed to explore for the first time whether age influences the predictive power of Hospital Frailty Risk Score to predict a long length of stay.
View Article and Find Full Text PDFIntroduction: Frailty, characterized by a reduction in intrinsic capacity across multiple physiological systems, is a key concern in healthy aging. Insight in the trajectory of an individual's functional ability and intrinsic reserve capacity in a relatively younger population of older adults is lacking. This study aims to investigate the early stages of frailty by tracking trajectories of physical indicators of intrinsic capacity before frailty becomes clinically evident.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock.
Importance: Patients with kidney failure (KF) receiving long-term dialysis have increased incidence of atrial fibrillation (AF). Patients with KF and AF have increased risk of stroke, death, and bleeding compared with age-matched cohorts. In KF, the use of oral anticoagulants (OACs) increases hemorrhage risk, offsetting potential benefits and making left atrial appendage occlusion (LAAO) a potentially promising solution for risk reduction in AF.
View Article and Find Full Text PDFJ Neurooncol
September 2025
Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Purpose: Frailty measures are critical for predicting outcomes in metastatic spine disease (MSD) patients. This study aimed to evaluate frailty measures throughout the disease process.
Methods: This retrospective analysis measured frailty in MSD patients at multiple time points using a modified Metastatic Spinal Tumor Frailty Index (MSTFI).