Whole-body magnetic resonance imaging for cutaneous melanoma staging: A scientific review.

Background: Cutaneous melanoma is an aggressive skin cancer with high metastatic potential. Accurate staging is critical to guide therapeutic strategies and improve prognosis. Whole-body magnetic resonance imaging (WB-MRI), particularly when combined with diffusion-weighted imaging (DWI), has emerged as promising tool for comprehensive, radiation-free assessment of metastatic spread.

Many Faces of Melanoma: A Comparison Between Cutaneous, Mucosal, Acral, Nail, and Ocular Malignancy.

A melanoma is a malignant neoplasm that originates from melanocytes. Melanocytes are found in various body sites-they are most commonly found in the skin (including acral sites and nail units), ocular structures, and mucosal membranes. This narrative review aims to comprehensively summarize the current information available regarding several types of melanomas and to analyze the existing evidence.

Transforming Atopic Dermatitis Management: Probiotics as a Game-Changer in Immune Modulation-A Double-Blind, Placebo-Controlled Clinical Trial.

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by immune dysregulation and microbiota imbalances. It affects millions worldwide, leading to significant morbidity and reduced quality of life. The disease is marked by intense pruritus, xerosis, and eczematous lesions, often accompanied by psychological distress and sleep disturbances.

Self-induced discoloration of the face with red exogenous pigment detected by dermoscopy: a novel type of dermatitis artefacta in the COVID-19 era.

Dear Editor, Dermatitis artefacta (DA) is a condition on the border of psychiatry and dermatology, characterized by patients intentionally causing skin lesions to pretend that they are ill. DA is a very challenging entity to diagnose, as it can mimic many other disorders and is usually recognized only after exclusion of all other diseases. Herein, we report three cases of a novel cutaneous condition that could fall into the spectrum of DA.

Dermoscopic Image Digital Post-Processing Perception and Use Among Members of the International Dermoscopy Society: Results of a Web-based Survey.

Introduction: Speculatively, digital image post-processing (DIPP) enhances diagnostic accuracy in dermoscopy.

Objective: We aimed to investigate the advantages and limitations of DIPP, as well as its perceived reliability and safety.

Methods: In this study we investigated the perception and use of DIPP among members of the International Dermoscopy Society through a web-based survey with 17 questions focusing on: (i) demographics (sex, age, nationality, specialty, professional experience in dermoscopy), (ii) application of digital dermoscopy, (iii) imaging devices, (iv) DIPP software usage, (v) area of DIPP application (e.

Real-World Efficacy of Tirbanibulin in Actinic Keratosis Treatment: Expert Consensus and Clinical Insights.

Introduction: Tirbanibulin, a topical treatment for actinic keratosis (AK) with a novel antiproliferative mechanism of action, has demonstrated efficacy and a favorable tolerability profile in clinical trials and real-life studies. An insight into best-practice use of tirbanibulin in different clinical presentations of AK would be useful.

Objectives: The aim of this article was to deliver advice, via expert consensus, on the optimal use of tirbanibulin in the real-life management of AK.

Psoriasiform Dermatitis: From Pathogenesis to New Therapeutic Opportunities.

Psoriasiform dermatitis refers to a spectrum of inflammatory skin disorders that resemble psoriasis both clinically and histologically. These conditions can occur idiopathically or as paradoxical reactions to biologic or targeted therapies, particularly in patients with atopic or autoimmune backgrounds. Histologic features often include acanthosis, parakeratosis, and lymphocytic infiltrates, but without the full molecular signature of classical psoriasis.

Acute generalized exanthematous pustulosis triggered by dupilumab.

Dear Editor, We present a rare but clinically significant case of acute generalized exanthematous pustulosis (AGEP) following the administration of dupilumab in a patient with refractory atopic dermatitis (AD). While dupilumab is widely regarded as a safe and effective biologic agent for moderate-to-severe AD across age groups - including adolescents, adults, and increasingly children - emerging reports underscore the need to remain vigilant for uncommon, severe cutaneous reactions. [.

Dermoscopy of kaposiform hemangioendothelioma: a case report.

Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy, characterized by an infiltrative, firm, and ill-defined plaque that may be associated with Kasabach-Merritt phenomenon. While the diagnosis is primarily clinical and histopathological, dermoscopy may provide valuable insights into its microstructural features. We present the case of a newborn with congenital KHE involving the lumbar and right gluteal region, focusing on its dermoscopic characteristics.

Cutaneous non-volar melanoma dermoscopy and histopathology correlation: a systematic review protocol.

Introduction: Dermoscopy has a proved validity in the diagnosis of cutaneous melanoma, which is one of the most aggressive forms of skin cancer. Although some studies have demonstrated a relationship between specific dermoscopic and pathologic melanoma features, there is no solid evidence allowing reliable conclusions. This study will evaluate the evidence regarding this association.

Digital dermoscopy follow-up for acquired longitudinal melanonychia.

Background: The differential diagnosis of early nail unit melanoma can be challenging.

Objective: This retrospective cross-sectional study aimed to characterize the clinical and dermoscopic changes in a series of cases of longitudinal melanonychia that underwent clinical and dermoscopic sequential digital monitoring.

Methods: All patients were adults presenting with a single acquired pigmented nail band and were monitored over time.

Post-COVID-19 resurgence of scabies in Campania, Italy: the hidden burden and challenges in surveillance.

Scabies, a contagious parasitic skin disease caused by Sarcoptes scabiei, has shown a marked resurgence in several European regions following the COVID-19 pandemic. In Campania, Italy, reported cases increased from 42 in 2020 to 748 in 2024, according to the regional surveillance system (Sistema Premal-UOD). However, the true burden of disease is likely underestimated due to widespread underreporting, delayed diagnosis, and a hidden reservoir of undetected or self-treated cases.

Skin Photodamage and Melanomagenesis: A Comprehensive Review.

Melanoma, the most aggressive form of skin cancer, still represents a significant and growing public health concern. Ultraviolet radiation (UVR) is considered the primary driver of melanoma, although genetic predisposition also plays a critical role. This review explores the intricate molecular mechanisms by which UVR-induced photodamage contributes to melanoma development.

Erosive Pustular Dermatosis of the Scalp Mimicking Squamous Cell Carcinoma: Can Dermoscopy Be Helpful?

Introduction: Erosive pustular dermatosis of the scalp (EPDS) presents as a rare and challenging skin disorder marked by erosions, pustules, and crusted lesions on the scalp. Diagnosing EPDS is complex, often mimicking other dermatological conditions like actinic keratosis (AK), basal cell carcinoma (BCC), or squamous cell carcinoma (SCC). Therapeutic challenges arise from EPDS's chronic, relapsing nature, which requires long-term management.

Management of Local Skin Reactions Caused by 5-FU 4% Cream for the Treatment of Actinic Keratosis: A Delphi Consensus.

Introduction: Treatments such as 4% 5-fluorouracil (5-FU) cream have demonstrated strong efficacy in lesion clearance of actinic keratosis; however, local skin reactions (LSR) during treatment remain a significant challenge, potentially affecting patient adherence.

Objective: We sought to build consensus on management of LSR associated with 4% 5-FU using the Delphi methodology.

Methods: Twenty-eight expert dermatologists participated in a 3-round Delphi process.

Neoadjuvant Intralesional Methotrexate for Infiltrating Squamous Cell Carcinoma of the Head: A Case Series of 19 Patients.

Squamous cell carcinoma (SCC) of the head presents a significant challenge in achieving complete surgical excision while preserving function and aesthetics. Neoadjuvant intralesional methotrexate (MTX) has emerged as a potential strategy to reduce tumour burden preoperatively, facilitating more conservative surgical excisions. The results demonstrated significant lesion shrinkage, with a mean tumour size reduction of 68%, enabling less invasive surgical interventions.

Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), the Italian Society of Dermatology and Sexually Transmitted Diseases (SIDeMaST), the Italian Society of Nutraceuticals (SINut), Club Ketodiets and Nutraceuticals "KetoNut-SINut" and the Italian Society of Endocrinology (SIE), Club Nutrition, Hormones and Metabolism.

Dermatological diseases such as acne, hidradenitis suppurativa (HS), and psoriasis are driven by chronic inflammation and oxidative stress. Emerging evidence highlights the role of nutrition in modulating these conditions, particularly through dietary patterns rich in antioxidants, polyphenols, and unsaturated fatty acids. RECENT FINDINGS: The Mediterranean diet (MedDiet) has demonstrated potential benefits due to its anti-inflammatory and immunomodulatory effects, while very low-energy ketogenic therapy (VLEKT) has shown promise in rapidly improving disease severity.