Acquired epileptic aphasia in NMDA encephalitis: a unique electroclinical presentation with pathophysiological considerations.

A boy in his middle childhood who was premorbidly normal presented with new-onset seizures and progressive auditory aphasia, raising suspicion of Landau-Kleffner Syndrome (LKS). Continuous spike and wave during sleep with a left centrotemporal spike pattern on the electroencephalogram (EEG) supported the preliminary diagnosis. But the febrile episodes after admission and the MRI findings suggestive of autoimmune encephalitis changed the diagnostic considerations.

Design, synthesis, crystal structure of novel hydrazone analogues as SARS-CoV-2 potent inhibitors: MD simulations, MM-GBSA, docking and ADMET studies.

In this study, we have synthesized novel thiohydrazone and hydrazone analogues by one-pot methodology with good to excellent yields (85%-91%). molecular dynamics (MD) simulations, docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) were evaluated as inhibitor activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PDB ID: 5N5O) main protease. The dynamics simulations studies and docking were conducted by GROMACS and AutoDock Vina.

Cross species transmission and recombination dynamics of chilli leaf curl virus: implications for host range expansion and LAMP-based detection.

Unlabelled: Plants of okra, marigold, pineapple, neem, datura, duranta, mirabilis, pedilanthus, helichrysum, and castor exhibiting various symptoms were collected from different locations in Karnataka (India). To confirm begomovirus infection, PCR amplification was performed on 45 symptomatic samples from various crops using begomovirus-specific primers. The complete genomes of chilli leaf curl virus (ChLCuV) and its associated betasatellite were successfully amplified, cloned, and sequenced from all ten affected crops.

A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.

The beating of cilia on multi-ciliated cells (MCCs) is essential for normal development and homeostasis in animals. But while the structure and function of basal bodies and axonemes have received significant attention recently, the distal tips of MCC cilia remain relatively poorly defined. Here, we characterize the molecular organization of the distal tip of vertebrate MCC cilia, characterizing two distinct domains occupied by distinct protein constituents.