Spontaneous Focal Hemorrhage of Optic Disc in Peripapillary Hyperreflective Ovoid Mass-Like Structures.

Introduction: Spontaneous focal hemorrhage of optic disc in peripapillary hyperreflective ovoid mass-like structures (PHOMS) is rare. This study reports the image features of two cases of spontaneous hemorrhage of an optic disc in PHOMS.

Methods: : A 51-year-old woman complained of visual fatigue for 1 week.

EOG and the En-Face Inner Segment/Outer Segment-Ellipsoid Complex Image in Multiple Evanescent White Dot Syndrome.

Introduction: This study presents a rare case of multiple evanescent white dot syndrome (MEWDS) with atypical electrooculogram (EOG) findings, as well as abnormal en-face images of minimum intensity projection (Min-IP) and the en-face inner segment/outer segment-ellipsoid complex.

Methods: A 25-year-old female patient presented with painless visual impairment and photopsia in her right eye for a duration of two days. Multimodal imaging was employed including color fundus photography (CFP), fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCTA), and en-face images of Min-IP and the en-face inner segment/outer segment-ellipsoid complex were performed.

Case Report: Optic Disc Melanocytoma with PHOMS-Minimum Intensity Projection Image.

Introduction: Optic disc melanocytoma (ODMC) with peripapillary hyperreflective ovoid mass-like structures (PHOMS) is rare. This study reports a case of the characteristics of multimodal imaging and Minimum intensity projection (Min-IP) images.

Methods: A 25-year-old male patient was referred to our hospital due to the presence of a dark pigmented tumor located in the optic disc area of his left eye.

The Novel Structural Variation in the GHR Gene Is Associated with Growth Traits in Yaks ().

The growth hormone receptor () is a member of the cytokine/hematopoietic factor receptor superfamily, which plays an important role in the growth and development, immunity, and metabolism of animals. This study identified a 246 bp deletion variant in the intronic region of the gene, and three genotypes, including type II, type ID, and type DD, were observed. Genotype analysis of structural variation (SV) was performed on 585 individuals from 14 yak breeds, and it was found that 246 bp deletion was present in each breed.

Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing.

Background: As the direct organ of villus, hair follicles have obvious seasonal cycles. The hair follicle cycle is orchestrated by multiple cell types that together direct cell renewal and differentiation. But the regulation property of hair follicle cells from anagen to catagen in yak is still unknown.

Prevention and Detection Research of Intelligent Sports Rehabilitation under the Background of Artificial Intelligence.

Artificial intelligence can bring convenience to human life. In the field of sports rehabilitation, the application of artificial intelligence is becoming more and more in-depth. This paper is aimed at studying the prevention and detection of sports rehabilitation in the context of artificial intelligence and proposing a compliance control method for lower limb rehabilitation robots based on artificial neural networks.

The Aquaporin TaPIP2;10 Confers Resistance to Two Fungal Diseases in Wheat.

Plants employ aquaporins (AQPs) of the plasma membrane intrinsic protein (PIP) family to import environmental substrates, thereby affecting various processes, such as the cellular responses regulated by the signaling molecule hydrogen peroxide (HO). Common wheat () contains 24 candidate members of the PIP family, designated as TaPIP1;1 to TaPIP1;12 and TaPIP2;1 to TaPIP2;12. None of these TaPIP candidates have been characterized for substrate selectivity or defense responses in their source plant.

Lamp location optimization for achievable rate maximization in visible light communication.

Visible light communication has received great attention as the superior candidate for radio frequency communication in indoor scenarios, but research on how the location of light-emitting diode lamps affects the achievable rate is rare. In this Letter, the lamp location is optimized with the Adam algorithm for maximization of the average achievable rate, and the Monte Carlo method based on sub-sampling is proposed to reduce the computational complexity of both the achievable rate calculation and optimization process. Moreover, the relationship between room sizes and numbers of lamps is investigated, while the optimal distributions of lamp locations are also illustrated.

ACY‑1215, a HDAC6 inhibitor, decreases the dexamethasone‑induced suppression of osteogenesis in MC3T3‑E1 cells.

Glucocorticoid‑induced osteoporosis is the commonest form of drug‑induced osteoporosis. Histone deacetylase 6 (HDAC6) is involved in the differentiation from mesenchymal stem cells to osteoblasts. However, the role of ricolinostat (ACY‑1215, HDAC6 inhibitor) in the dexamethasone (Dex)‑induced proliferation and differentiation of preosteoblasts remains to be elucidated.

Constellation optimization under the ergodic VLC channel based on generalized spatial modulation.

When the generalized spatial modulation (GSM) is applied to visible light communication (VLC), radio frequency (RF) technologies, such as constellation designs, should be modified for the ergodic VLC channel, which is different from that in typical RF environments. In this paper, constellations of amplitude-phase modulation (APM) symbols are optimized for GSM-based VLC systems in which optical signals must be real-valued and non-negative, while the ergodic VLC channel and the random characteristic of receiver locations are also considered. The algorithm of statistically convergent gradient descent (SCGD) is adopted for the maximization of coded modulation average mutual information (CM-AMI), and superior performances of optimal constellations are verified by numerical simulations.

Nystagmus associated with macular dysplasia.

: To describe Optical Coherence Tomography (OCT) findings of the macula in patients with nystagmus, mainly the relationship between spectral-domain OCT (SD-OCT) images and nystagmus in macular dysplasia.: In this study, 17 cases (29 eyes) with congenital macular abnormalities in patients with albinism, macular heterotopias, congenital aniridia, foveal hypoplasia, congenital macular coloboma, and congenital retinoschisis were retrospectively analyzed. Patients underwent multimodal retinal imaging examinations including ultra-widefield fundus imaging, SD-OCT, autofluorescence, and visual field.

A High-Speed Target-Free Vision-Based Sensor for Bus Rapid Transit Viaduct Vibration Measurements Using CMT and ORB Algorithms.

Bus Rapid Transit (BRT) has become an increasing source of concern for public transportation of modern cities. Traditional contact sensing techniques during the process of health monitoring of BRT viaducts cannot overcome the deficiency that the normal free-flow of traffic would be blocked. Advances in computer vision technology provide a new line of thought for solving this problem.

Excitation-emission matrix spectroscopy and parallel factor analysis for micro-content petroleum pollutant.

In order to solve the identification problem of oil pollutants containing micro content, the fluorescence characteristics of oil samples were studied using fluorescence excitation emission matrix spectra (EEMs) combined with parallel factor (PARAFAC) analysis. According to the conventional standard of oil content in water, simulated the component of oil pollution in I-V water was simulated by preparing samples of CCL4 with oil content. Firstly, measured the EEMs of 97# gasoline, 0# diesel, kerosene and CCL4 were measured individually, then the EEMs of 97# gasoline, 0# diesel, and kerosene in CCL4 were measured, and finally, the EEMs of the composite sample with all three oil contents in CCL4 were measured.

Determination of glucose and uric acid with bienzyme colorimetry on microfluidic paper-based analysis devices.

In this work, we first employ a drying method combining with the bienzyme colorimetric detection of glucose and uric acid on microfluidic paper-based analysis devices (μPADs). The channels of 3D μPADs are also designed by us to get better results. The color results are recorded by both Gel Documentation systems and a common camera.

A higher number of circulating tumor cells (CTC) in peripheral blood indicates poor prognosis in prostate cancer patients--a meta-analysis.

Objective: The prevalence of prostate cancer (PCa) is high and PCa is the most common cutaneous cancer in men worldwide. Despite extensive research efforts, very few biomarkers of PCa have been introduced to date in clinical practice. A meta-analysis was performed on the most recently reported CTC to assess its prognostic effect and to elucidate whether its detection in the peripheral blood of patients diagnosed with metastatic, castration-resistant prostate cancer (CPRC) and Hormone Refractory Prostate Cancer (HRPC) can be used as a prognostic factor for survival.

Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport.

Axonal transport is critical for neuronal function and survival. Cytoplasmic dynein and its accessory complex dynactin form a microtubule minus end-directed motor in charge of retrograde transport. In this study, we show that Nudel, a dynein regulator, was highly expressed in dorsal root ganglion (DRG) neurons.

Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin.

Adhesion and detachment are coordinated critical steps during cell migration. Conceptually, efficient migration requires both effective stabilization of membrane protrusions at the leading edge via nascent adhesions and their successful persistence during retraction of the trailing side via disruption of focal adhesions. As nascent adhesions are much smaller in size than focal adhesions, they are expected to exhibit a stronger adhesivity in order to achieve the coordination between cell front and back.

Enhanced expression of Rab27A gene by breast cancer cells promoting invasiveness and the metastasis potential by secretion of insulin-like growth factor-II.

In addition to the functions of transporting melanosome in melanocytes and releasing contents of lytic granules in CTLs, Rab27A was recently shown to be involved in exocytosis of insulin and chromaffin granules in endocrine cells; it was also reported to be expressed in an exceptionally broad range of specialized secretory cells. As autocrine and paracrine cytokines are essential for invasion and metastasis in some solid tumors, blocking them may be an effective strategy to prevent tumor dissemination. In the present study, we show that Rab27A is associated with invasive and metastatic potentials of human breast cancer cells.

The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous tubules.

Sertoli cells of testis belong to a unique type of polarized epithelial cells and are essential for spermatogenesis. They form the blood-testis barrier at the base of seminiferous tubule. Their numerous long, microtubule-rich processes extend inward and associate with developing germ cells to sustain germ cell growth and differentiation.

Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase.

The microtubule-based motor cytoplasmic dynein/dynactin is a force generator at the kinetochore. It also transports proteins away from kinetochores to spindle poles. Regulation of such diverse functions, however, is poorly understood.

Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.

The centrosome is the major microtubule-organizing center in animal cells. Although the cytoplasmic dynein regulator Nudel interacts with centrosomes, its role herein remains unclear. Here, we show that in Cos7 cells Nudel is a mother centriole protein with rapid turnover independent of dynein activity.

Aptamers that preferentially bind type IVB pili and inhibit human monocytic-cell invasion by Salmonella enterica serovar typhi.

Salmonella enterica serovar Typhi is an important pathogen exclusively for humans and causes typhoid or enteric fever. It has been shown that type IVB pili, encoded by the S. enterica serovar Typhi pil operon located in Salmonella pathogenicity island 7, are important in the pathogenic process.

Type IVB piliated Salmonella typhi enhance IL-6 and NF-kappaB production in human monocytic THP-1 cells through activation of protein kinase C.

Salmonella typhi is an important human pathogen responsible for typhoid fever. Type IVB pili, encoded by the S. typhi pil operon located in the major pathogenicity island, are used to facilitate bacterial entry into human intestinal cells in vitro and may be important in the mediation of enteric fever in humans.

T-box binding site mediates the dorsal activation of myf-5 in Xenopus gastrula embryos.

Myf-5, a member of the muscle regulatory factor family of transcription factors, plays an important role in the determination, development, and differentiation of the skeletal muscle. Factors that regulate the expression of myf-5 itself are not well understood. We show here that a T-box binding site in the Xenopus myf-5 promoter mediated the activation of myf-5 expression through specific interaction with nuclear proteins of gastrula embryos.