Molecular Determinants of Thrombosis Recurrence Risk Across Venous Thromboembolism Subtypes.

Venous thromboembolism (VTE) is a frequent (annual incidence of 1-2 per 1,000) and potentially life-threatening (case-fatality rate up to 10%) disease. VTE is associated with serious short-term and long-term complications, including a recurrence rate approaching 20% within five years. Anticoagulant therapy, the mainstay of VTE treatment, drastically reduces the risk of early VTE recurrence, but it exposes patients to a substantial risk of bleeding.

Venous Thrombosis Associated with Different Types of SARS-CoV-2 Vaccines in the Netherlands-Results of the TERA Case-Control Study.

The magnitude of the risk of venous thromboembolism (VTE) after SARS-CoV-2 vaccines is debated.We included patients with a first VTE in 2021 and controls from a sample of Dutch citizens. Participants completed a questionnaire on VTE risk factors and vaccination, with data linked to Statistics Netherlands.

Plasma -Glycan Signatures Are Associated With a First Event of Venous Thromboembolism.

Background: Coagulation factors play important roles in the pathophysiology of venous thromboembolism (VTE), and most of them are glycoproteins, that is, proteins containing glycans attached. Although the connection between glycosylation and coagulation factors seems obvious, the association between glycosylation and VTE risk remains unexplored. We aimed to elucidate the association between -glycans in plasma and VTE risk in the MEGA study (Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis), a case-control study aiming to identify risk factors for VTE.

Prevalence of cardiovascular risk factors in persons with venous thromboembolism aged 50 years or younger.

The risk of cardiovascular disease (CVD) is elevated in individuals with a history of venous thromboembolism (VTE). It is uncertain whether younger patients, aged ≤50 years, have an increased prevalence of potentially modifiable CVD risk factors, which could be targeted for prevention. We aimed to estimate the prevalence of potentially modifiable CVD risk factors (ie, overweight/obesity, smoking, alcohol use, physical inactivity, hypertension, diabetes mellitus, and dyslipidemia) in persons aged ≤50 years with a history of VTE (cases) and compare with those without VTE (controls).

Polygenic prediction of body mass index and obesity through the life course and across ancestries.

Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.

Metabotype identification via fasting and postprandial metabolomics and its association with type 2 diabetes incidence.

Background: Metabotypes represent distinct metabolic profiles that groups of individuals share, facilitating disease risk stratification. We aimed to apply metabolomics to identify metabotypes in different prandial states and examine its associations with type 2 diabetes mellitus (T2DM) risk.

Methods: Using fasting and postprandial metabolomic data from the Netherlands Epidemiology of Obesity (NEO) study (N = 5320), we applied -means clustering to identify individual’s metabotypes for three prandial states (fasting, postprandial [150 min after meal], and postprandial minus fasting, i.

Footprints from childhood: intra- versus extra-familial childhood maltreatment and attachment to romantic partners in adulthood.

Background: Childhood maltreatment may have long lasting consequences on adult attachment and intimate relationships in adulthood. Attached security in adulthood varies depending on the type of abuse and the perpetrator, i.e.

The relation between visceral fat and lung function in the general population is in part mediated by CRP and leptin.

Background: Abdominal obesity is associated with reduced lung function. It remains unclear whether this results from mechanical pressure or whether visceral fat also plays a role via inflammation. Our aim was to examine the association between visceral fat and lung function, and the role of inflammation.

Genome-wide interaction study with BMI identifies CYP7A1 and GIPR as genetic modulators of MASLD.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) may progress to liver inflammation, fibrosis, cirrhosis and hepatocellular carcinoma. So far, genome-wide association studies explain a small fraction of MASLD heritability.

Objective: We sought to identify novel genetic determinants of MASLD by exploring interactions between genetic variants and body mass index (BMI).

A multiomics approach reveals novel regulators of plasma factor V levels, highlighting CLEC4M as a clearance receptor.

Coagulation factor V (FV) is a key protein in maintaining the hemostatic balance, with abnormal plasma levels associated with both thrombotic and hemorrhagic conditions. We propose a comprehensive bioinformatic analysis integrating large-scale proteogenomics and transcriptomic data from original and public data sets. We identify a biological fingerprint of 26 new proteins and loci involved in the regulation of plasma FV levels.

Neighborhood Retail Food Environment, Diet Quality and Type 2 Diabetes Incidence in 4 Dutch Cohorts.

Background: Current evidence on the associations between the food environment and type 2 diabetes (T2D) is inconsistent and did not investigate the behavioral mediating pathway.

Objectives: To investigate whether accessibility of food retailers in the residential neighborhood is associated with T2D incidence in 4 Dutch prospective cohorts, and whether this is mediated by diet quality.

Methods: In this prospective multicohort study, we included 4 Dutch cohort studies (n = 10,249).

Bone marrow lesions and collateral ligament lesions are associated in interphalangeal joints with osteoarthritis: The Hand OSTeoArthritis in Secondary care cohort.

Objectives: To investigate whether bone activity adjacent to collateral ligaments is present and results in collateral ligament lesions (CLLs) of the proximal and distal interphalangeal joints in patients with hand osteoarthritis (OA), and vice versa.

Methods: We used data measured on baseline, year two and year four from the Hand OSTeoArthritis in Secondary care cohort. MR images of the right hand were scored at the radial and ulnar 1/3rd of each joint ("=joint side") for bone marrow lesions (BMLs) and CLLs (=non-visible or non-continuous ligament).

Amount and timing of physical activity in relation to sleep quality in the general middle-aged Dutch population: A cross-sectional analysis.

Objectives: To examine whether the amount and timing of moderate-to-vigorous physical activity (MVPA) was associated with sleep quality and duration in the general population.

Methods: This is a cross-sectional analysis of data of a Dutch cohort collected between 2008 and 2012. Timing of physical activity (measured using an accelerometer) was categorized as performing most MVPA in morning (06:00-12:00), afternoon (12:00-18:00), evening (18:00-00:00), or even distribution of MVPA over the day (reference).

Translational genomics of osteoarthritis in 1,962,069 individuals.

Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed.

Risk of First Venous Thrombosis by Comparing Different Thrombin Generation Assay Conditions: Results from the MEGA Case-control Study.

Background: Hypercoagulability is a risk factor for venous thromboembolism (VTE). Thrombin generation (TG) is a global coagulation assay that measures an individual's clotting tendency. We hypothesise that slow-onset TG (achieved by using a low procoagulant stimulus or an inhibitor of coagulation) is the optimal responsive TG method for detecting hypercoagulability.

A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.

Background: Gene-environment interactions may enhance our understanding of hypertension. Our previous study highlighted the importance of considering psychosocial factors in gene discovery for blood pressure (BP) but was limited in statistical power and population diversity. To address these challenges, we conducted a multi-population genome-wide association study (GWAS) of BP accounting for gene-depressive symptomatology (DEPR) interactions in a larger and more diverse sample.

Glycoprotein acetyls response to a mixed meal is associated with increased insulin resistance and risk of type 2 diabetes in a middle-aged population.

Background & Aims: Systemic inflammation increases the risk of type 2 diabetes (T2D). It remains unclear whether the inflammatory meal response identifies other people at risk of T2D than fasting levels alone. We aimed to examine associations between the meal response of glycoprotein acetyls (GlycA) with insulin resistance and incident type 2 diabetes.

Association of Cardiovascular Risk Factors With Major and Minor Electrocardiographic Abnormalities: A Report From the Cross-Sectional Phase of Tehran Cohort Study.

Background And Aims: In the current study, we aimed to identify the association between major and minor electrocardiographic abnormalities and cardiovascular risk factors.

Methods: We used the Tehran cohort study baseline data, an ongoing multidisciplinary, longitudinal study designed to identify cardiovascular disease risk factors in the adult population of Tehran. The electrocardiograms (ECGs) of 7630 Iranian adults aged 35 years and above were analyzed.

In clinical hand osteoarthritis research, self-reported pain questionnaires do not reflect the patient experience.

Objective: Pain in hand osteoarthritis (OA) is evaluated with repeated pain questionnaires. It is unclear whether these questionnaires adequately capture changes in pain recalled by patients. This study investigated whether changes on pain questionnaires (real-time evaluation) correspond to recalled pain.

Excess mortality during the first 2 years of the COVID-19 pandemic (2020-2021) in the Netherlands: Overall and across demographic subgroups.

Objectives: The overall impact of the COVID-19 pandemic on mortality can be estimated by the assessment of excess deaths from all causes because the reported number of deaths due to COVID-19 do not accurately reflect the true death toll. We assessed excess mortality in 2020 and 2021 in the Netherlands.

Methods: All analyses were performed on data from comprehensive nationwide registers provided by Statistics Netherlands (Centraal Bureau voor de Statistiek), including demographic characteristics and mortality.

Robust Metabolomic Age Prediction Based on a Wide Selection of Metabolites.

Chronological age is a major risk factor for numerous diseases. However, chronological age does not capture the complex biological aging process. The difference between chronological age and biologically driven aging could be more informative in reflecting health status.

Synovitis scoring in hand osteoarthritis with ultrasonography: the performance of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) is comparable to synovial thickening alone.

Background: Inflammation is increasingly recognised as a treatment target in hand osteoarthritis, and therefore correct measurement of local inflammation is essential. This study aimed to assess ultrasound scoring of synovitis and the additional value of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) in hand osteoarthritis.

Methods: Data from the randomised, double-blinded Hand Osteoarthritis Prednisolone Efficacy (HOPE) trial were used.