Publications by authors named "Casper A P Burik"
Article Synopsis
- Conducted a genome-wide association study involving over 668,000 individuals of European descent to explore how genetics relates to income and socio-economic status.
- Identified 162 genetic loci associated with income, with a polygenic index explaining only 1-5% of income variance and showing stronger connections to mental health issues than physical health.
- Revealed that the genetic correlation between income and educational attainment is significant, with implications for understanding the dual impacts on health risks and behaviors.
Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets.
View Article and Find Full Text PDFWe conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P < 5 × 10), while five of the 21 lead SNPs reach suggestive significance (P < 1 × 10) for at least one other macronutrient.
View Article and Find Full Text PDFGenetic instrumental variable regression: Explaining socioeconomic and health outcomes in nonexperimental data.
Proc Natl Acad Sci U S A
May 2018
Identifying causal effects in nonexperimental data is an enduring challenge. One proposed solution that recently gained popularity is the idea to use genes as instrumental variables [i.e.
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