A capture enzyme-linked immunosorbent assay for detection of mosquito salivary protein-specific immunoglobulin E.

Mosquito saliva contains numerous distinct mosquito salivary proteins (MSPs) that mediate mosquito-host interactions. Repeated mosquito exposure can trigger allergic reactions, with MSP-specific IgE playing a central role. Current enzyme-linked immunosorbent assay (ELISA) and immunoblotting methods for detecting MSP-specific IgE suffer from interference by much more abundant MSP-specific IgG, leading to low sensitivity.

Emergence of two new lineages of the cosmopolitan dengue virus serotype 2 in Yunnan, China, 2024.

Background: Dengue fever has become a significant epidemic in South and Southeast Asia. Recently, Yunnan Province in southwestern China, which borders these regions, has also experienced a significant outbreak. This study aims to investigate the genetic diversity of the dengue virus (DENV) and identify potential sources of transmission in Xishuangbanna, Yunnan Province in 2024.

An oral polyphenol host-guest nanoparticle for targeted therapy of inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a global public health challenge that affects millions of people. Current medical treatments for IBD are not fully effective and may cause undesirable side effects on patients. Thus, there is an urgent need for safe, simple, and efficacious strategies to treat IBD in clinical settings.

CARD11 is a prognostic biomarker and correlated with immune infiltrates in uveal melanoma.

Uveal melanoma (UVM), the most common primary intraocular malignancy, has a high mortality because of a high propensity to metastasize. Our study analyzed prognostic value and immune-related characteristics of CARD11 in UVM, hoping to provide a potential management and research direction. The RNA-sequence data of 80 UVM patients were downloaded from The Cancer Genome Atlas database and divided them into high- and low-expression groups.

The nine ADAMs family members serve as potential biomarkers for immune infiltration in pancreatic adenocarcinoma.

Background: The functional significance of ADAMs family members in the immune infiltration of pancreatic adenocarcinoma (PAAD) awaits elucidation.

Methods: ADAMs family members with significant expression were identified among differentially expressed genes of PAAD based on The Cancer Genome Atlas (TCGA) database followed by a verification based on the Oncomine database. The correlation of ADAMs in PAAD was estimated with the Spearman's rho value.

Study on the Impact of Historic District Built Environment and Its Influence on Residents' Walking Trips: A Case Study of Zhangzhou Ancient City's Historic District.

Walking maintains an indisputable advantage as a simple transport mode over short distances. Various situations have shown that when staying in a walk-friendly built environment, people are more likely to walk and interact with their surroundings. Scholars have reported some evidence of the influence of neighbourhood environments on personal walking trips.

The potential drug for treatment in pancreatic adenocarcinoma: a bioinformatical study based on distinct drug databases.

Background: The prediction of drug-target interaction from chemical and biological data can advance our search for potential drug, contributing to a therapeutic strategy for pancreatic adenocarcinoma (PAAD). We aim to identify hub genes of PAAD and search for potential drugs from distinct databases. The docking simulation is adopted to validate our findings from computable perspective.

Molecular characterization of the viral structural gene of the first dengue virus type 1 outbreak in Xishuangbanna: A border area of China, Burma and Laos.

Background: Xishuangbanna, a border area of China, Burma and Laos, had its first major DENV-1 outbreak in 2017. This study aims to explore the genetic characterization, potential source and evolution of the viruses in outbreak.

Methods: The structural protein C/prM/E genes of viruses isolated from local residents or Burmese travelers were sequenced followed by mutation, phylogenetic, homologous recombination, molecular clock and demographic reconstruction analysis.